E2F target genes: unraveling the biology.

Adrian P Bracken; Marco Ciro; Andrea Cocito; Kristian Helin

E2F target genes: unraveling the biology.

Adrian P Bracken, Marco Ciro, Andrea Cocito, Kristian Helin

392 Citations (Scopus)

Abstract

The E2F transcription factors are downstream effectors of the retinoblastoma protein (pRB) pathway and are required for the timely regulation of numerous genes essential for DNA replication and cell cycle progression. Several laboratories have used genome-wide approaches to discover novel target genes of E2F, leading to the identification of several hundred such genes that are involved not only in DNA replication and cell cycle progression, but also in DNA damage repair, apoptosis, differentiation and development. These new findings greatly enrich our understanding of how E2F controls transcription and cellular homeostasis.

Original language	English
Journal	TIBS -Trends in Biochemical Sciences. Regular ed.
Volume	29
Issue number	8
Pages (from-to)	409-17
Number of pages	8
ISSN	0968-0004
Publication status	Published - 2004

Cite this

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title = "E2F target genes: unraveling the biology.",

abstract = "The E2F transcription factors are downstream effectors of the retinoblastoma protein (pRB) pathway and are required for the timely regulation of numerous genes essential for DNA replication and cell cycle progression. Several laboratories have used genome-wide approaches to discover novel target genes of E2F, leading to the identification of several hundred such genes that are involved not only in DNA replication and cell cycle progression, but also in DNA damage repair, apoptosis, differentiation and development. These new findings greatly enrich our understanding of how E2F controls transcription and cellular homeostasis.",

author = "Bracken, {Adrian P} and Marco Ciro and Andrea Cocito and Kristian Helin",

note = "Keywords: Animals; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; DNA Damage; DNA Repair; DNA Replication; DNA-Binding Proteins; E2F Transcription Factors; Forecasting; Humans; Mitosis; Transcription Factors",

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T1 - E2F target genes: unraveling the biology.

AU - Bracken, Adrian P

AU - Ciro, Marco

AU - Cocito, Andrea

AU - Helin, Kristian

N1 - Keywords: Animals; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; DNA Damage; DNA Repair; DNA Replication; DNA-Binding Proteins; E2F Transcription Factors; Forecasting; Humans; Mitosis; Transcription Factors

PY - 2004

Y1 - 2004

N2 - The E2F transcription factors are downstream effectors of the retinoblastoma protein (pRB) pathway and are required for the timely regulation of numerous genes essential for DNA replication and cell cycle progression. Several laboratories have used genome-wide approaches to discover novel target genes of E2F, leading to the identification of several hundred such genes that are involved not only in DNA replication and cell cycle progression, but also in DNA damage repair, apoptosis, differentiation and development. These new findings greatly enrich our understanding of how E2F controls transcription and cellular homeostasis.

AB - The E2F transcription factors are downstream effectors of the retinoblastoma protein (pRB) pathway and are required for the timely regulation of numerous genes essential for DNA replication and cell cycle progression. Several laboratories have used genome-wide approaches to discover novel target genes of E2F, leading to the identification of several hundred such genes that are involved not only in DNA replication and cell cycle progression, but also in DNA damage repair, apoptosis, differentiation and development. These new findings greatly enrich our understanding of how E2F controls transcription and cellular homeostasis.

M3 - Review

C2 - 15362224

SN - 0968-0004

VL - 29

SP - 409

EP - 417

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 8

ER -

E2F target genes: unraveling the biology.

Abstract

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