Dissociation in a polymerization model of homochirality

A. Brandenburg; A. C. Andersen; M. Nilsson

doi:10.1007/s11084-005-5757-y

Dissociation in a polymerization model of homochirality

A. Brandenburg^*, A. C. Andersen, M. Nilsson

^*Corresponding author for this work

14 Citations (Scopus)

Abstract

A fully self-contained model of homochirality is presented that contains the effects of both polymerization and dissociation. The dissociation fragments are assumed to replenish the substrate from which new monomers can grow and undergo new polymerization. The mean length of isotactic polymers is found to grow slowly with the normalized total number of corresponding building blocks. Alternatively, if one assumes that the dissociation fragments themselves can polymerize further, then this corresponds to a strong source of short polymers, and an unrealistically short average length of only 3. By contrast, without dissociation, isotactic polymers becomes infinitely long.

Original language	English
Journal	Origins of Life and Evolution of the Biosphere
Volume	35
Issue number	6
Pages (from-to)	507-521
Number of pages	15
ISSN	0169-6149
DOIs	https://doi.org/10.1007/s11084-005-5757-y
Publication status	Published - 1 Dec 2005

Keywords

DNA polymerization
Enantiomeric cross-inhibition
Origin of homochirality Revision: 1.41

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T1 - Dissociation in a polymerization model of homochirality

AU - Brandenburg, A.

AU - Andersen, A. C.

AU - Nilsson, M.

PY - 2005/12/1

Y1 - 2005/12/1

N2 - A fully self-contained model of homochirality is presented that contains the effects of both polymerization and dissociation. The dissociation fragments are assumed to replenish the substrate from which new monomers can grow and undergo new polymerization. The mean length of isotactic polymers is found to grow slowly with the normalized total number of corresponding building blocks. Alternatively, if one assumes that the dissociation fragments themselves can polymerize further, then this corresponds to a strong source of short polymers, and an unrealistically short average length of only 3. By contrast, without dissociation, isotactic polymers becomes infinitely long.

AB - A fully self-contained model of homochirality is presented that contains the effects of both polymerization and dissociation. The dissociation fragments are assumed to replenish the substrate from which new monomers can grow and undergo new polymerization. The mean length of isotactic polymers is found to grow slowly with the normalized total number of corresponding building blocks. Alternatively, if one assumes that the dissociation fragments themselves can polymerize further, then this corresponds to a strong source of short polymers, and an unrealistically short average length of only 3. By contrast, without dissociation, isotactic polymers becomes infinitely long.

KW - DNA polymerization

KW - Enantiomeric cross-inhibition

KW - Origin of homochirality Revision: 1.41

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SN - 0169-6149

VL - 35

SP - 507

EP - 521

JO - Origins of Life and Evolution of Biospheres

JF - Origins of Life and Evolution of Biospheres

IS - 6

ER -

Dissociation in a polymerization model of homochirality

Abstract

Keywords

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