Abstract
Protein elicits a stronger early (30 min) glucose-dependent insulinotropic polypeptide (GIP) response than fat ingestion in lean individuals, with no difference in glucagon-like peptide-1 (GLP-1). We assessed the incretin hormone response to protein versus fat ingestion in obesity. Equicaloric (8 kcal/kg) fat (olive oil) or protein (whey protein) was ingested by non-diabetic obese male volunteers [body mass index (BMI) >30 kg/m(2) ; n = 12] and plasma GIP and GLP-1 were determined. We found no difference in the early GIP or GLP-1 responses to fat versus protein. However, the total 300-min GIP response was greater after fat than after protein ingestion (20.3 ± 3.9 vs. 10.0 ± 2.8 nmol/l × min; p = 0.026), whereas the 300-min GLP-1 responses were the same. Thus, in obesity, protein and fat ingestion elicit similar early (30 min) incretin hormone responses, whereas 300-min GIP secretion is more pronounced after fat than protein ingestion.
| Original language | English |
|---|---|
| Journal | Diabetes, Obesity and Metabolism Online |
| Volume | 13 |
| Issue number | 9 |
| Pages (from-to) | 863-865 |
| Number of pages | 3 |
| ISSN | 1463-1326 |
| DOIs | |
| Publication status | Published - Sept 2011 |
Keywords
- Adult
- Dietary Fats
- Dietary Proteins
- Gastric Inhibitory Polypeptide
- Glucagon-Like Peptide 1
- Humans
- Incretins
- Male
- Obesity
