Detection of Polish clinical Aspergillus fumigatus isolates resistant to triazoles

Urszula Nawrot; Ewelina Kurzyk; Maiken Cavling Arendrup; Martyna Mroczynska; Katarzyna Wlodarczyk; Beata Sulik-Tyszka; Marta Wróblewska; Marek Ussowicz; Przemyslaw Zdziarski; Kinga Niewinska; Anna Brillowska-Dabrowska

doi:10.1093/mmy/myx012

Detection of Polish clinical Aspergillus fumigatus isolates resistant to triazoles

Urszula Nawrot, Ewelina Kurzyk, Maiken Cavling Arendrup, Martyna Mroczynska, Katarzyna Wlodarczyk, Beata Sulik-Tyszka, Marta Wróblewska, Marek Ussowicz, Przemyslaw Zdziarski, Kinga Niewinska, Anna Brillowska-Dabrowska

Department of Clinical Medicine

11 Citations (Scopus)

Abstract

We studied the presence of triazole resistance of 121 Aspergillus fumigatus clinical isolates collected in two Polish cities, Warsaw and Wroclaw, to determine if resistance is emerging in our country. We identified five itraconazole resistant isolates (4.13%) carrying the TR₃₄/L98H alteration in Cyp51A gene, four of which were cross-resistant to posaconazole and one to voriconazole. One isolate was intermediate susceptible to itraconazole and harbored no Cyp51A alterations. The study confirms the presence of azole resistant A. fumigatus strains in Poland at a level that is comparative to other European countries.

Original language	English
Journal	Medical Mycology
Volume	56
Issue number	1
Pages (from-to)	121-124
ISSN	1369-3786
DOIs	https://doi.org/10.1093/mmy/myx012
Publication status	Published - 1 Jan 2018

Keywords

Antifungal Agents/pharmacology
Aspergillosis/microbiology
Aspergillus fumigatus/drug effects
Cities
Cytochrome P-450 Enzyme System/genetics
Drug Resistance, Fungal
Fungal Proteins/genetics
Genotype
Humans
Mutation, Missense
Poland
Triazoles/pharmacology

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title = "Detection of Polish clinical Aspergillus fumigatus isolates resistant to triazoles",

abstract = "We studied the presence of triazole resistance of 121 Aspergillus fumigatus clinical isolates collected in two Polish cities, Warsaw and Wroclaw, to determine if resistance is emerging in our country. We identified five itraconazole resistant isolates (4.13%) carrying the TR34/L98H alteration in Cyp51A gene, four of which were cross-resistant to posaconazole and one to voriconazole. One isolate was intermediate susceptible to itraconazole and harbored no Cyp51A alterations. The study confirms the presence of azole resistant A. fumigatus strains in Poland at a level that is comparative to other European countries.",

keywords = "Antifungal Agents/pharmacology, Aspergillosis/microbiology, Aspergillus fumigatus/drug effects, Cities, Cytochrome P-450 Enzyme System/genetics, Drug Resistance, Fungal, Fungal Proteins/genetics, Genotype, Humans, Mutation, Missense, Poland, Triazoles/pharmacology",

author = "Urszula Nawrot and Ewelina Kurzyk and Arendrup, {Maiken Cavling} and Martyna Mroczynska and Katarzyna Wlodarczyk and Beata Sulik-Tyszka and Marta Wr{\'o}blewska and Marek Ussowicz and Przemyslaw Zdziarski and Kinga Niewinska and Anna Brillowska-Dabrowska",

note = "{\textcopyright} The Author 2017. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: [email protected].",

year = "2018",

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doi = "10.1093/mmy/myx012",

language = "English",

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T1 - Detection of Polish clinical Aspergillus fumigatus isolates resistant to triazoles

AU - Nawrot, Urszula

AU - Kurzyk, Ewelina

AU - Arendrup, Maiken Cavling

AU - Mroczynska, Martyna

AU - Wlodarczyk, Katarzyna

AU - Sulik-Tyszka, Beata

AU - Wróblewska, Marta

AU - Ussowicz, Marek

AU - Zdziarski, Przemyslaw

AU - Niewinska, Kinga

AU - Brillowska-Dabrowska, Anna

N1 - © The Author 2017. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: [email protected].

PY - 2018/1/1

Y1 - 2018/1/1

N2 - We studied the presence of triazole resistance of 121 Aspergillus fumigatus clinical isolates collected in two Polish cities, Warsaw and Wroclaw, to determine if resistance is emerging in our country. We identified five itraconazole resistant isolates (4.13%) carrying the TR34/L98H alteration in Cyp51A gene, four of which were cross-resistant to posaconazole and one to voriconazole. One isolate was intermediate susceptible to itraconazole and harbored no Cyp51A alterations. The study confirms the presence of azole resistant A. fumigatus strains in Poland at a level that is comparative to other European countries.

AB - We studied the presence of triazole resistance of 121 Aspergillus fumigatus clinical isolates collected in two Polish cities, Warsaw and Wroclaw, to determine if resistance is emerging in our country. We identified five itraconazole resistant isolates (4.13%) carrying the TR34/L98H alteration in Cyp51A gene, four of which were cross-resistant to posaconazole and one to voriconazole. One isolate was intermediate susceptible to itraconazole and harbored no Cyp51A alterations. The study confirms the presence of azole resistant A. fumigatus strains in Poland at a level that is comparative to other European countries.

KW - Antifungal Agents/pharmacology

KW - Aspergillosis/microbiology

KW - Aspergillus fumigatus/drug effects

KW - Cities

KW - Cytochrome P-450 Enzyme System/genetics

KW - Drug Resistance, Fungal

KW - Fungal Proteins/genetics

KW - Genotype

KW - Humans

KW - Mutation, Missense

KW - Poland

KW - Triazoles/pharmacology

U2 - 10.1093/mmy/myx012

DO - 10.1093/mmy/myx012

M3 - Journal article

C2 - 28340159

SN - 1369-3786

VL - 56

SP - 121

EP - 124

JO - Medical Mycology

JF - Medical Mycology

IS - 1

ER -

Detection of Polish clinical Aspergillus fumigatus isolates resistant to triazoles

Abstract

Keywords

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