Design of an injectable in situ gelation biomaterials for vitreous substitute

Masahiko Annaka; Kell Mortensen; Martin Etchells Vigild; Toyoaki Matsuura; Souichiro Tsuji; Tetsuo Ueda; Hiroki Tsujinaka

doi:10.1021/bm201012f

Design of an injectable in situ gelation biomaterials for vitreous substitute

Masahiko Annaka, Kell Mortensen, Martin Etchells Vigild, Toyoaki Matsuura, Souichiro Tsuji, Tetsuo Ueda, Hiroki Tsujinaka

32 Citations (Scopus)

Abstract

To adapt the physical properties of living materials to their biological function, nature developed various types of polymers with outstanding physical behavior. One example is the vitreous body, which is important intraocular elements not only because of its optical and mechanical performances, but also due to its important role in the pathogenesis and treatment of conditions affecting adjacent tissues and eventually the whole eye. Here, we report a novel biocompatible material for injectable vitreous substitute, composed of thermosensitive amphiphilic polymer, which is capable of forming a transparent gel in the vitreous cavity. It is nontoxic, provides adequate support for the retina, and allows light to reach the sensory elements at the back of the eye. The amphiphilic polymer exhibits mechanical stability by assembling to form highly interconnected hydrophobic domains, which leads to the constitution of a network structure.

Original language	English
Journal	Biomacromolecules
Volume	12
Issue number	11
Pages (from-to)	4011-4021
Number of pages	11
ISSN	1525-7797
DOIs	https://doi.org/10.1021/bm201012f
Publication status	Published - 14 Nov 2011

Access to Document

10.1021/bm201012f

Cite this

@article{74f1e767ee704c84a748207b33620bc5,

title = "Design of an injectable in situ gelation biomaterials for vitreous substitute",

abstract = "To adapt the physical properties of living materials to their biological function, nature developed various types of polymers with outstanding physical behavior. One example is the vitreous body, which is important intraocular elements not only because of its optical and mechanical performances, but also due to its important role in the pathogenesis and treatment of conditions affecting adjacent tissues and eventually the whole eye. Here, we report a novel biocompatible material for injectable vitreous substitute, composed of thermosensitive amphiphilic polymer, which is capable of forming a transparent gel in the vitreous cavity. It is nontoxic, provides adequate support for the retina, and allows light to reach the sensory elements at the back of the eye. The amphiphilic polymer exhibits mechanical stability by assembling to form highly interconnected hydrophobic domains, which leads to the constitution of a network structure.",

author = "Masahiko Annaka and Kell Mortensen and Vigild, {Martin Etchells} and Toyoaki Matsuura and Souichiro Tsuji and Tetsuo Ueda and Hiroki Tsujinaka",

year = "2011",

month = nov,

day = "14",

doi = "10.1021/bm201012f",

language = "English",

volume = "12",

pages = "4011--4021",

journal = "Biomacromolecules",

issn = "1525-7797",

publisher = "American Chemical Society",

number = "11",

}

TY - JOUR

T1 - Design of an injectable in situ gelation biomaterials for vitreous substitute

AU - Annaka, Masahiko

AU - Mortensen, Kell

AU - Vigild, Martin Etchells

AU - Matsuura, Toyoaki

AU - Tsuji, Souichiro

AU - Ueda, Tetsuo

AU - Tsujinaka, Hiroki

PY - 2011/11/14

Y1 - 2011/11/14

N2 - To adapt the physical properties of living materials to their biological function, nature developed various types of polymers with outstanding physical behavior. One example is the vitreous body, which is important intraocular elements not only because of its optical and mechanical performances, but also due to its important role in the pathogenesis and treatment of conditions affecting adjacent tissues and eventually the whole eye. Here, we report a novel biocompatible material for injectable vitreous substitute, composed of thermosensitive amphiphilic polymer, which is capable of forming a transparent gel in the vitreous cavity. It is nontoxic, provides adequate support for the retina, and allows light to reach the sensory elements at the back of the eye. The amphiphilic polymer exhibits mechanical stability by assembling to form highly interconnected hydrophobic domains, which leads to the constitution of a network structure.

AB - To adapt the physical properties of living materials to their biological function, nature developed various types of polymers with outstanding physical behavior. One example is the vitreous body, which is important intraocular elements not only because of its optical and mechanical performances, but also due to its important role in the pathogenesis and treatment of conditions affecting adjacent tissues and eventually the whole eye. Here, we report a novel biocompatible material for injectable vitreous substitute, composed of thermosensitive amphiphilic polymer, which is capable of forming a transparent gel in the vitreous cavity. It is nontoxic, provides adequate support for the retina, and allows light to reach the sensory elements at the back of the eye. The amphiphilic polymer exhibits mechanical stability by assembling to form highly interconnected hydrophobic domains, which leads to the constitution of a network structure.

U2 - 10.1021/bm201012f

DO - 10.1021/bm201012f

M3 - Journal article

C2 - 21988210

SN - 1525-7797

VL - 12

SP - 4011

EP - 4021

JO - Biomacromolecules

JF - Biomacromolecules

IS - 11

ER -

Design of an injectable in situ gelation biomaterials for vitreous substitute

Abstract

Access to Document

Fingerprint

Cite this