Abstract
OBJECTIVE: The purpose of this study was to examine the associations between objectively measured physical activity and serum brain-derived neurotrophic factor (BDNF) in adolescents.
METHODS: Cross-sectional analyses were performed using data from 415 adolescents who participated in the 2015 follow-up of the Childhood Health Activity and Motor Performance School Study Denmark (the CHAMPS-study DK). Physical activity was objectively measured by accelerometry monitors. Serum BDNF levels were analyzed using the Enzyme-linked immunosorbent assay (ELISA). Anthropometrics and pubertal status were measured using standardized procedures.
RESULTS: With adjustment for age, pubertal status and body mass index, mean physical activity (counts per minute) was negatively associated with serum BDNF in boys (P=0.013). Similarly, moderate-to-vigorous physical activity (MVPA) was negatively associated with serum BDNF in boys (P=0.035). In girls, mean physical activity and MVPA were not associated with serum BDNF. Without adjustment for wear time, sedentary time was not associated with serum BDNF in either sex.
CONCLUSION: These findings indicate that higher physical activity is associated with lower serum BDNF in boys, but not in girls.
| Original language | English |
|---|---|
| Journal | Physiology & Behavior |
| Volume | 171 |
| Pages (from-to) | 87-91 |
| Number of pages | 5 |
| ISSN | 0031-9384 |
| DOIs | |
| Publication status | Published - 15 Mar 2017 |
Keywords
- Accelerometry
- Adolescent
- Anthropometry
- Brain-Derived Neurotrophic Factor/blood
- Cross-Sectional Studies
- Enzyme-Linked Immunosorbent Assay
- Exercise/physiology
- Female
- Humans
- Male
- Motor Activity
- Sedentary Lifestyle
- Sexual Maturation/physiology