Closed-chest-grisemodellen er overlegen ved interventionsstudier af iskæmiperfusionsskade

Sarah Victoria Ekeløf Busch; Natalie Løvland Halladin; Svend Eggert Jensen; Jacob Rosenberg; Ismail Gögenur

Closed-chest-grisemodellen er overlegen ved interventionsstudier af iskæmiperfusionsskade

Translated title of the contribution: Closed-chest porcine model is superior in intervention studies of ischaemia reperfusion injury.

Sarah Victoria Ekeløf Busch, Natalie Løvland Halladin, Svend Eggert Jensen, Jacob Rosenberg, Ismail Gögenur

6 Citations (Scopus)

Abstract

Ischaemia reperfusion injury affects the patients' clinical outcomes. An animal model is therefore required in order to test pharmacological interventions and improve the current treatment of acute myocardial infarction (AMI). This review focuses on the endovascular closed-chest porcine model of ischaemia and reperfusion. In contrast to the open-chest porcine model the closed-chest model closely mimics the clinical situation of an AMI and makes it possible to extrapolate the results directly to humans. The model is well suited for future interventional studies.

Translated title of the contribution	Closed-chest porcine model is superior in intervention studies of ischaemia reperfusion injury.
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	174
Issue number	26
Pages (from-to)	1807-1810
Number of pages	4
ISSN	0041-5782
Publication status	Published - 2012

Cite this

@article{373773fb914a4bd9ae17375d9e05948b,

title = "Closed-chest-grisemodellen er overlegen ved interventionsstudier af isk{\ae}miperfusionsskade",

abstract = "Ischaemia reperfusion injury affects the patients' clinical outcomes. An animal model is therefore required in order to test pharmacological interventions and improve the current treatment of acute myocardial infarction (AMI). This review focuses on the endovascular closed-chest porcine model of ischaemia and reperfusion. In contrast to the open-chest porcine model the closed-chest model closely mimics the clinical situation of an AMI and makes it possible to extrapolate the results directly to humans. The model is well suited for future interventional studies.",

author = "Busch, {Sarah Victoria Ekel{\o}f} and Halladin, {Natalie L{\o}vland} and Jensen, {Svend Eggert} and Jacob Rosenberg and Ismail G{\"o}genur",

year = "2012",

language = "Dansk",

volume = "174",

pages = "1807--1810",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

publisher = "Almindelige Danske Laegeforening",

number = "26",

}

TY - JOUR

T1 - Closed-chest-grisemodellen er overlegen ved interventionsstudier af iskæmiperfusionsskade

AU - Busch, Sarah Victoria Ekeløf

AU - Halladin, Natalie Løvland

AU - Jensen, Svend Eggert

AU - Rosenberg, Jacob

AU - Gögenur, Ismail

PY - 2012

Y1 - 2012

N2 - Ischaemia reperfusion injury affects the patients' clinical outcomes. An animal model is therefore required in order to test pharmacological interventions and improve the current treatment of acute myocardial infarction (AMI). This review focuses on the endovascular closed-chest porcine model of ischaemia and reperfusion. In contrast to the open-chest porcine model the closed-chest model closely mimics the clinical situation of an AMI and makes it possible to extrapolate the results directly to humans. The model is well suited for future interventional studies.

AB - Ischaemia reperfusion injury affects the patients' clinical outcomes. An animal model is therefore required in order to test pharmacological interventions and improve the current treatment of acute myocardial infarction (AMI). This review focuses on the endovascular closed-chest porcine model of ischaemia and reperfusion. In contrast to the open-chest porcine model the closed-chest model closely mimics the clinical situation of an AMI and makes it possible to extrapolate the results directly to humans. The model is well suited for future interventional studies.

M3 - Tidsskriftartikel

SN - 0041-5782

VL - 174

SP - 1807

EP - 1810

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 26

ER -

Closed-chest-grisemodellen er overlegen ved interventionsstudier af iskæmiperfusionsskade

Abstract

Fingerprint

Cite this