Child Maltreatment and Clinical Outcome in Individuals at Ultra-High Risk for Psychosis in the EU-GEI High Risk Study

Tamar C. Kraan; Eva Velthorst; Manouk Themmen; Lucia R. Valmaggia; Matthew J. Kempton; Phillip McGuire; Jim Van Os; Bart P.F. Rutten; Filip Smit; Lieuwe De Haan; Mark Van Der Gaag; Philip McGuire; Lucia R. Valmaggia; Maria Calem; Stefania Tognin; Gemma Modinos; Nadine Burger; Daniella S. Van Dam; Neus Barrantes-Vidal; Tecelli Domínguez-Martínez; Paula Cristóbal-Narváez; Thomas R. Kwapil; Manel Monsonet-Bardají; Lídia Hinojosa; Anita Riecher-Rössler; Stefan Borgwardt; Charlotte Rapp; Sarah Ittig; Erich Studerus; Renata Smieskova; Rodrigo Bressan; Ary Gadelha; Elisa Brietzke; Graccielle Asevedo; Elson Asevedo; Andre Zugman; Stephan Ruhrmann; Dominika Gebhard; Julia Arnhold; Joachim Klosterkötter; Dorte Nordholm; Lasse Randers; Kristine Krakauer; Tanya Louise Naumann; Louise Birkedal Glenthøj; Merete Nordentoft; Marc De Hert; Ruud Van Winkel; Barnaby Nelson; Patrick McGorry

doi:10.1093/schbul/sbw162

Child Maltreatment and Clinical Outcome in Individuals at Ultra-High Risk for Psychosis in the EU-GEI High Risk Study

Tamar C. Kraan, Eva Velthorst, Manouk Themmen, Lucia R. Valmaggia, Matthew J. Kempton, Phillip McGuire, Jim Van Os, Bart P.F. Rutten, Filip Smit, Lieuwe De Haan, Mark Van Der Gaag^*, Philip McGuire, Lucia R. Valmaggia, Maria Calem, Stefania Tognin, Gemma Modinos, Nadine Burger, Daniella S. Van Dam, Neus Barrantes-Vidal, Tecelli Domínguez-MartínezPaula Cristóbal-Narváez, Thomas R. Kwapil, Manel Monsonet-Bardají, Lídia Hinojosa, Anita Riecher-Rössler, Stefan Borgwardt, Charlotte Rapp, Sarah Ittig, Erich Studerus, Renata Smieskova, Rodrigo Bressan, Ary Gadelha, Elisa Brietzke, Graccielle Asevedo, Elson Asevedo, Andre Zugman, Stephan Ruhrmann, Dominika Gebhard, Julia Arnhold, Joachim Klosterkötter, Dorte Nordholm, Lasse Randers, Kristine Krakauer, Tanya Louise Naumann, Louise Birkedal Glenthøj, Merete Nordentoft, Marc De Hert, Ruud Van Winkel, Barnaby Nelson, Patrick McGorry

^*Corresponding author for this work

Department of Clinical Medicine

15 Citations (Scopus)

Abstract

Background: Child maltreatment has been associated with a wide range of mental disorders in adulthood. Whether child maltreatment is specifically associated with psychosis risk in individuals at ultra-high risk (UHR) for psychosis, or leads to a general vulnerability for overall psychopathology in the UHR stage remains unclear. The present study examines the association between child maltreatment and transition to psychosis and other mental disorders. Methods: The sample consisted of 259 UHR individuals from the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Participants were followed-up for 2 years to assess clinical outcome. Clinical outcome was assessed at 6 months, 12 months, and 24 months after baseline. Child maltreatment before the age of 17 years was assessed at baseline. Results: Our findings show that a history of emotional abuse was associated with an increased risk for transition to psychosis (OR = 3.78, 95% CI = 1.17 to 12.39, P = -027). Apart from psychosis, a history of physical abuse was associated with depressive disorder (OR = 4.92, 95% CI = 2.12 to 11.39, P = .001), post-traumatic stress disorder (OR = 2.06, 95% CI = 1.10 to 3.86, P = .023), panic disorder (OR = 2.00, 95% CI = 1.00 to 3.99, P = .048) and social phobia (OR = 2.47, 95% CI = 1.18 to 5.16, P = .016) at follow-up. Conclusion: Our findings suggest that in the UHR stage child maltreatment is a pluripotent risk factor for developing psychosis, depressive disorder, post-traumatic stress disorder (PTSD), panic disorder, and social phobia in adulthood.

Original language	English
Journal	Schizophrenia Bulletin
Volume	44
Issue number	3
Pages (from-to)	584-592
Number of pages	9
ISSN	0586-7614
DOIs	https://doi.org/10.1093/schbul/sbw162
Publication status	Published - 2018

Keywords

child maltreatment
clinical outcome
psychosis
ultra high risk

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Kraan, T. C., Velthorst, E., Themmen, M., Valmaggia, L. R., Kempton, M. J., McGuire, P., Van Os, J., Rutten, B. P. F., Smit, F., De Haan, L., Van Der Gaag, M., McGuire, P., Valmaggia, L. R., Calem, M., Tognin, S., Modinos, G., Burger, N., Van Dam, D. S., Barrantes-Vidal, N., ... McGorry, P. (2018). Child Maltreatment and Clinical Outcome in Individuals at Ultra-High Risk for Psychosis in the EU-GEI High Risk Study. Schizophrenia Bulletin, 44(3), 584-592. https://doi.org/10.1093/schbul/sbw162

Kraan, TC, Velthorst, E, Themmen, M, Valmaggia, LR, Kempton, MJ, McGuire, P, Van Os, J, Rutten, BPF, Smit, F, De Haan, L, Van Der Gaag, M, McGuire, P, Valmaggia, LR, Calem, M, Tognin, S, Modinos, G, Burger, N, Van Dam, DS, Barrantes-Vidal, N, Domínguez-Martínez, T, Cristóbal-Narváez, P, Kwapil, TR, Monsonet-Bardají, M, Hinojosa, L, Riecher-Rössler, A, Borgwardt, S, Rapp, C, Ittig, S, Studerus, E, Smieskova, R, Bressan, R, Gadelha, A, Brietzke, E, Asevedo, G, Asevedo, E, Zugman, A, Ruhrmann, S, Gebhard, D, Arnhold, J, Klosterkötter, J, Nordholm, D, Randers, L, Krakauer, K, Naumann, TL, Glenthøj, LB, Nordentoft, M, De Hert, M, Van Winkel, R, Nelson, B & McGorry, P 2018, 'Child Maltreatment and Clinical Outcome in Individuals at Ultra-High Risk for Psychosis in the EU-GEI High Risk Study', Schizophrenia Bulletin, vol. 44, no. 3, pp. 584-592. https://doi.org/10.1093/schbul/sbw162

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title = "Child Maltreatment and Clinical Outcome in Individuals at Ultra-High Risk for Psychosis in the EU-GEI High Risk Study",

abstract = "Background: Child maltreatment has been associated with a wide range of mental disorders in adulthood. Whether child maltreatment is specifically associated with psychosis risk in individuals at ultra-high risk (UHR) for psychosis, or leads to a general vulnerability for overall psychopathology in the UHR stage remains unclear. The present study examines the association between child maltreatment and transition to psychosis and other mental disorders. Methods: The sample consisted of 259 UHR individuals from the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Participants were followed-up for 2 years to assess clinical outcome. Clinical outcome was assessed at 6 months, 12 months, and 24 months after baseline. Child maltreatment before the age of 17 years was assessed at baseline. Results: Our findings show that a history of emotional abuse was associated with an increased risk for transition to psychosis (OR = 3.78, 95% CI = 1.17 to 12.39, P = -027). Apart from psychosis, a history of physical abuse was associated with depressive disorder (OR = 4.92, 95% CI = 2.12 to 11.39, P = .001), post-traumatic stress disorder (OR = 2.06, 95% CI = 1.10 to 3.86, P = .023), panic disorder (OR = 2.00, 95% CI = 1.00 to 3.99, P = .048) and social phobia (OR = 2.47, 95% CI = 1.18 to 5.16, P = .016) at follow-up. Conclusion: Our findings suggest that in the UHR stage child maltreatment is a pluripotent risk factor for developing psychosis, depressive disorder, post-traumatic stress disorder (PTSD), panic disorder, and social phobia in adulthood.",

keywords = "child maltreatment, clinical outcome, psychosis, ultra high risk",

author = "Kraan, {Tamar C.} and Eva Velthorst and Manouk Themmen and Valmaggia, {Lucia R.} and Kempton, {Matthew J.} and Phillip McGuire and {Van Os}, Jim and Rutten, {Bart P.F.} and Filip Smit and {De Haan}, Lieuwe and {Van Der Gaag}, Mark and Philip McGuire and Valmaggia, {Lucia R.} and Maria Calem and Stefania Tognin and Gemma Modinos and Nadine Burger and {Van Dam}, {Daniella S.} and Neus Barrantes-Vidal and Tecelli Dom{\'i}nguez-Mart{\'i}nez and Paula Crist{\'o}bal-Narv{\'a}ez and Kwapil, {Thomas R.} and Manel Monsonet-Bardaj{\'i} and L{\'i}dia Hinojosa and Anita Riecher-R{\"o}ssler and Stefan Borgwardt and Charlotte Rapp and Sarah Ittig and Erich Studerus and Renata Smieskova and Rodrigo Bressan and Ary Gadelha and Elisa Brietzke and Graccielle Asevedo and Elson Asevedo and Andre Zugman and Stephan Ruhrmann and Dominika Gebhard and Julia Arnhold and Joachim Klosterk{\"o}tter and Dorte Nordholm and Lasse Randers and Kristine Krakauer and Naumann, {Tanya Louise} and Glenth{\o}j, {Louise Birkedal} and Merete Nordentoft and {De Hert}, Marc and {Van Winkel}, Ruud and Barnaby Nelson and Patrick McGorry",

year = "2018",

doi = "10.1093/schbul/sbw162",

language = "English",

volume = "44",

pages = "584--592",

journal = "Schizophrenia Bulletin",

issn = "0586-7614",

publisher = "Oxford University Press",

number = "3",

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TY - JOUR

T1 - Child Maltreatment and Clinical Outcome in Individuals at Ultra-High Risk for Psychosis in the EU-GEI High Risk Study

AU - Kraan, Tamar C.

AU - Velthorst, Eva

AU - Themmen, Manouk

AU - Valmaggia, Lucia R.

AU - Kempton, Matthew J.

AU - McGuire, Phillip

AU - Van Os, Jim

AU - Rutten, Bart P.F.

AU - Smit, Filip

AU - De Haan, Lieuwe

AU - Van Der Gaag, Mark

AU - McGuire, Philip

AU - Valmaggia, Lucia R.

AU - Calem, Maria

AU - Tognin, Stefania

AU - Modinos, Gemma

AU - Burger, Nadine

AU - Van Dam, Daniella S.

AU - Barrantes-Vidal, Neus

AU - Domínguez-Martínez, Tecelli

AU - Cristóbal-Narváez, Paula

AU - Kwapil, Thomas R.

AU - Monsonet-Bardají, Manel

AU - Hinojosa, Lídia

AU - Riecher-Rössler, Anita

AU - Borgwardt, Stefan

AU - Rapp, Charlotte

AU - Ittig, Sarah

AU - Studerus, Erich

AU - Smieskova, Renata

AU - Bressan, Rodrigo

AU - Gadelha, Ary

AU - Brietzke, Elisa

AU - Asevedo, Graccielle

AU - Asevedo, Elson

AU - Zugman, Andre

AU - Ruhrmann, Stephan

AU - Gebhard, Dominika

AU - Arnhold, Julia

AU - Klosterkötter, Joachim

AU - Nordholm, Dorte

AU - Randers, Lasse

AU - Krakauer, Kristine

AU - Naumann, Tanya Louise

AU - Glenthøj, Louise Birkedal

AU - Nordentoft, Merete

AU - De Hert, Marc

AU - Van Winkel, Ruud

AU - Nelson, Barnaby

AU - McGorry, Patrick

PY - 2018

Y1 - 2018

N2 - Background: Child maltreatment has been associated with a wide range of mental disorders in adulthood. Whether child maltreatment is specifically associated with psychosis risk in individuals at ultra-high risk (UHR) for psychosis, or leads to a general vulnerability for overall psychopathology in the UHR stage remains unclear. The present study examines the association between child maltreatment and transition to psychosis and other mental disorders. Methods: The sample consisted of 259 UHR individuals from the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Participants were followed-up for 2 years to assess clinical outcome. Clinical outcome was assessed at 6 months, 12 months, and 24 months after baseline. Child maltreatment before the age of 17 years was assessed at baseline. Results: Our findings show that a history of emotional abuse was associated with an increased risk for transition to psychosis (OR = 3.78, 95% CI = 1.17 to 12.39, P = -027). Apart from psychosis, a history of physical abuse was associated with depressive disorder (OR = 4.92, 95% CI = 2.12 to 11.39, P = .001), post-traumatic stress disorder (OR = 2.06, 95% CI = 1.10 to 3.86, P = .023), panic disorder (OR = 2.00, 95% CI = 1.00 to 3.99, P = .048) and social phobia (OR = 2.47, 95% CI = 1.18 to 5.16, P = .016) at follow-up. Conclusion: Our findings suggest that in the UHR stage child maltreatment is a pluripotent risk factor for developing psychosis, depressive disorder, post-traumatic stress disorder (PTSD), panic disorder, and social phobia in adulthood.

AB - Background: Child maltreatment has been associated with a wide range of mental disorders in adulthood. Whether child maltreatment is specifically associated with psychosis risk in individuals at ultra-high risk (UHR) for psychosis, or leads to a general vulnerability for overall psychopathology in the UHR stage remains unclear. The present study examines the association between child maltreatment and transition to psychosis and other mental disorders. Methods: The sample consisted of 259 UHR individuals from the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Participants were followed-up for 2 years to assess clinical outcome. Clinical outcome was assessed at 6 months, 12 months, and 24 months after baseline. Child maltreatment before the age of 17 years was assessed at baseline. Results: Our findings show that a history of emotional abuse was associated with an increased risk for transition to psychosis (OR = 3.78, 95% CI = 1.17 to 12.39, P = -027). Apart from psychosis, a history of physical abuse was associated with depressive disorder (OR = 4.92, 95% CI = 2.12 to 11.39, P = .001), post-traumatic stress disorder (OR = 2.06, 95% CI = 1.10 to 3.86, P = .023), panic disorder (OR = 2.00, 95% CI = 1.00 to 3.99, P = .048) and social phobia (OR = 2.47, 95% CI = 1.18 to 5.16, P = .016) at follow-up. Conclusion: Our findings suggest that in the UHR stage child maltreatment is a pluripotent risk factor for developing psychosis, depressive disorder, post-traumatic stress disorder (PTSD), panic disorder, and social phobia in adulthood.

KW - child maltreatment

KW - clinical outcome

KW - psychosis

KW - ultra high risk

U2 - 10.1093/schbul/sbw162

DO - 10.1093/schbul/sbw162

M3 - Journal article

C2 - 28666366

AN - SCOPUS:85045141193

SN - 0586-7614

VL - 44

SP - 584

EP - 592

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

IS - 3

ER -

Child Maltreatment and Clinical Outcome in Individuals at Ultra-High Risk for Psychosis in the EU-GEI High Risk Study

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Keywords

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