CD4+CD25+ regulatory T cells: II. Origin, disease models and clinical aspects

TY - JOUR

T1 - CD4+CD25+ regulatory T cells: II. Origin, disease models and clinical aspects

AU - Nielsen, Janne

AU - Holm, Thomas Lindebo

AU - Claesson, Mogens H

N1 - Keywords: Animals; Autoimmune Diseases; CD4-Positive T-Lymphocytes; Disease Models, Animal; Humans; Immune Tolerance; Receptors, Interleukin-2; T-Lymphocyte Subsets; T-Lymphocytes

PY - 2004

Y1 - 2004

N2 - Autoimmune diseases afflict approximately 5% of the population and reflect a failure in the immune system to discriminate between self and non-self resulting in the breakdown of self-tolerance. Regulatory CD4+CD25+ T cells (Treg cells) have been shown to play an important role in the maintenance of immune homeostasis and self-tolerance by counteracting the development and effector functions of potentially autoreactive T cells. We have in the previous APMIS review described the phenotype and physiology of Treg cells. The present overview deals with the thymic origin of Treg cells and their role in disease models such as autoimmune gastritis and inflammatory bowel disease. Finally, we will consider some aspects of the therapeutic potential of Treg cells.

AB - Autoimmune diseases afflict approximately 5% of the population and reflect a failure in the immune system to discriminate between self and non-self resulting in the breakdown of self-tolerance. Regulatory CD4+CD25+ T cells (Treg cells) have been shown to play an important role in the maintenance of immune homeostasis and self-tolerance by counteracting the development and effector functions of potentially autoreactive T cells. We have in the previous APMIS review described the phenotype and physiology of Treg cells. The present overview deals with the thymic origin of Treg cells and their role in disease models such as autoimmune gastritis and inflammatory bowel disease. Finally, we will consider some aspects of the therapeutic potential of Treg cells.

U2 - 10.1111/j.1600-0463.2004.apm1121002.x

DO - 10.1111/j.1600-0463.2004.apm1121002.x

M3 - Review

C2 - 15601315

SN - 0903-465X

VL - 112

SP - 642

EP - 650

JO - APMIS. Supplementum

JF - APMIS. Supplementum

IS - 10

ER -