Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study

B B Høyer; C H Ramlau-Hansen; T B Henriksen; H S Pedersen; K Góralczyk; V Zviezdai; B A G Jönsson; D Heederik; V Lenters; R Vermeulen; J P Bonde; G Toft

doi:10.1038/ijo.2014.58

Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study

B B Høyer, C H Ramlau-Hansen, T B Henriksen, H S Pedersen, K Góralczyk, V Zviezdai, B A G Jönsson, D Heederik, V Lenters, R Vermeulen, J P Bonde, G Toft

22 Citations (Scopus)

Abstract

OBJECTIVE: To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in 5- to 9-year-old children.

METHODS: Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N=1109) from Greenland, Warsaw (Poland), and Kharkiv (Ukraine) were analysed for CB-153 and p,p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and child age- and sex-specific BMI z-scores were calculated at follow-up (2010-2012), using multiple linear regression analysis.

RESULTS: No clear associations between pregnancy CB-153 and p,p'-DDE and child BMI were observed (the pooled differences in BMI z-score (95% confidence interval) comparing 3rd tertile to 1st tertile were -0.07 (-0.32 to 0.18) and -0.10 (-0.30 to 0.10) kg m(-2), respectively). For postnatal CB-153 and p,p'-DDE and BMI, the overall differences in BMI z-score comparing 3rd tertile to 1st tertile were 0.12 (-0.15 to 0.39) and -0.03 (-0.20 to 0.27) kg m(-2), respectively.

CONCLUSIONS: This follow-up study of Greenlandic, Polish and Ukrainian populations showed no clear association between pregnancy and postnatal exposure to p,p'-DDE and CB-153 and BMI at the age of 5-9 years.

Original language	English
Journal	International journal of obesity (2005)
Volume	38
Issue number	7
Pages (from-to)	919-925
Number of pages	7
ISSN	0307-0565
DOIs	https://doi.org/10.1038/ijo.2014.58
Publication status	Published - Jul 2014

Keywords

Adult
Body Mass Index
Child
Child, Preschool
DDT
Environmental Exposure
Environmental Pollutants
European Continental Ancestry Group
Female
Follow-Up Studies
Greenland
Humans
Hydrocarbons, Chlorinated
Male
Mothers
Poland
Polychlorinated Biphenyls
Pregnancy
Prenatal Exposure Delayed Effects
Prospective Studies
Ukraine

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10.1038/ijo.2014.58

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Høyer, B. B., Ramlau-Hansen, C. H., Henriksen, T. B., Pedersen, H. S., Góralczyk, K., Zviezdai, V., Jönsson, B. A. G., Heederik, D., Lenters, V., Vermeulen, R., Bonde, J. P., & Toft, G. (2014). Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study. International journal of obesity (2005), 38(7), 919-925. https://doi.org/10.1038/ijo.2014.58

Høyer, BB, Ramlau-Hansen, CH, Henriksen, TB, Pedersen, HS, Góralczyk, K, Zviezdai, V, Jönsson, BAG, Heederik, D, Lenters, V, Vermeulen, R, Bonde, JP & Toft, G 2014, 'Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study', International journal of obesity (2005), vol. 38, no. 7, pp. 919-925. https://doi.org/10.1038/ijo.2014.58

@article{9eb376f78a204068a6b7fbaf6a2999d2,

title = "Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study",

abstract = "OBJECTIVE: To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in 5- to 9-year-old children.METHODS: Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N=1109) from Greenland, Warsaw (Poland), and Kharkiv (Ukraine) were analysed for CB-153 and p,p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and child age- and sex-specific BMI z-scores were calculated at follow-up (2010-2012), using multiple linear regression analysis.RESULTS: No clear associations between pregnancy CB-153 and p,p'-DDE and child BMI were observed (the pooled differences in BMI z-score (95% confidence interval) comparing 3rd tertile to 1st tertile were -0.07 (-0.32 to 0.18) and -0.10 (-0.30 to 0.10) kg m(-2), respectively). For postnatal CB-153 and p,p'-DDE and BMI, the overall differences in BMI z-score comparing 3rd tertile to 1st tertile were 0.12 (-0.15 to 0.39) and -0.03 (-0.20 to 0.27) kg m(-2), respectively.CONCLUSIONS: This follow-up study of Greenlandic, Polish and Ukrainian populations showed no clear association between pregnancy and postnatal exposure to p,p'-DDE and CB-153 and BMI at the age of 5-9 years.",

keywords = "Adult, Body Mass Index, Child, Child, Preschool, DDT, Environmental Exposure, Environmental Pollutants, European Continental Ancestry Group, Female, Follow-Up Studies, Greenland, Humans, Hydrocarbons, Chlorinated, Male, Mothers, Poland, Polychlorinated Biphenyls, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Ukraine",

author = "H{\o}yer, {B B} and Ramlau-Hansen, {C H} and Henriksen, {T B} and Pedersen, {H S} and K G{\'o}ralczyk and V Zviezdai and J{\"o}nsson, {B A G} and D Heederik and V Lenters and R Vermeulen and Bonde, {J P} and G Toft",

year = "2014",

month = jul,

doi = "10.1038/ijo.2014.58",

language = "English",

volume = "38",

pages = "919--925",

journal = "International Journal of Obesity",

issn = "0307-0565",

publisher = "nature publishing group",

number = "7",

}

TY - JOUR

T1 - Body mass index in young school-age children in relation to organochlorine compounds in early life

T2 - a prospective study

AU - Høyer, B B

AU - Ramlau-Hansen, C H

AU - Henriksen, T B

AU - Pedersen, H S

AU - Góralczyk, K

AU - Zviezdai, V

AU - Jönsson, B A G

AU - Heederik, D

AU - Lenters, V

AU - Vermeulen, R

AU - Bonde, J P

AU - Toft, G

PY - 2014/7

Y1 - 2014/7

N2 - OBJECTIVE: To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in 5- to 9-year-old children.METHODS: Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N=1109) from Greenland, Warsaw (Poland), and Kharkiv (Ukraine) were analysed for CB-153 and p,p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and child age- and sex-specific BMI z-scores were calculated at follow-up (2010-2012), using multiple linear regression analysis.RESULTS: No clear associations between pregnancy CB-153 and p,p'-DDE and child BMI were observed (the pooled differences in BMI z-score (95% confidence interval) comparing 3rd tertile to 1st tertile were -0.07 (-0.32 to 0.18) and -0.10 (-0.30 to 0.10) kg m(-2), respectively). For postnatal CB-153 and p,p'-DDE and BMI, the overall differences in BMI z-score comparing 3rd tertile to 1st tertile were 0.12 (-0.15 to 0.39) and -0.03 (-0.20 to 0.27) kg m(-2), respectively.CONCLUSIONS: This follow-up study of Greenlandic, Polish and Ukrainian populations showed no clear association between pregnancy and postnatal exposure to p,p'-DDE and CB-153 and BMI at the age of 5-9 years.

AB - OBJECTIVE: To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in 5- to 9-year-old children.METHODS: Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N=1109) from Greenland, Warsaw (Poland), and Kharkiv (Ukraine) were analysed for CB-153 and p,p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and child age- and sex-specific BMI z-scores were calculated at follow-up (2010-2012), using multiple linear regression analysis.RESULTS: No clear associations between pregnancy CB-153 and p,p'-DDE and child BMI were observed (the pooled differences in BMI z-score (95% confidence interval) comparing 3rd tertile to 1st tertile were -0.07 (-0.32 to 0.18) and -0.10 (-0.30 to 0.10) kg m(-2), respectively). For postnatal CB-153 and p,p'-DDE and BMI, the overall differences in BMI z-score comparing 3rd tertile to 1st tertile were 0.12 (-0.15 to 0.39) and -0.03 (-0.20 to 0.27) kg m(-2), respectively.CONCLUSIONS: This follow-up study of Greenlandic, Polish and Ukrainian populations showed no clear association between pregnancy and postnatal exposure to p,p'-DDE and CB-153 and BMI at the age of 5-9 years.

KW - Adult

KW - Body Mass Index

KW - Child

KW - Child, Preschool

KW - DDT

KW - Environmental Exposure

KW - Environmental Pollutants

KW - European Continental Ancestry Group

KW - Female

KW - Follow-Up Studies

KW - Greenland

KW - Humans

KW - Hydrocarbons, Chlorinated

KW - Male

KW - Mothers

KW - Poland

KW - Polychlorinated Biphenyls

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects

KW - Prospective Studies

KW - Ukraine

U2 - 10.1038/ijo.2014.58

DO - 10.1038/ijo.2014.58

M3 - Journal article

C2 - 24718355

SN - 0307-0565

VL - 38

SP - 919

EP - 925

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 7

ER -

Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study

Abstract

Keywords

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