Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study.

Jørgen Vestbo; Eva Prescott; Thomas Peter Almdal; Morten Dahl; Børge G. Nordestgaard; Teis Andersen; Thorkild I. A. Sørensen; Peter Lange

Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study.

Jørgen Vestbo, Eva Prescott, Thomas Peter Almdal, Morten Dahl, Børge G. Nordestgaard, Teis Andersen, Thorkild I. A. Sørensen, Peter Lange

Department of Clinical Medicine

450 Citations (Scopus)

Abstract

Rationale: Low body mass index (BMI) is a marker of poor prognosis in chronic obstructive pulmonary disease (COPD). In the general population the harmful effect of low BMI is due to the deleterious effects of a low fat free mass index (FFMI, fat free mass/weight(2)). Objectives: We explored distribution of low FFMI and its association with prognosis in a population based cohort of COPD patients. Methods: We used data on 1,898 COPD patients identified in a population-based epidemiological study in Copenhagen. Fat free mass was measured using bioelectrical impedance analysis. Patients were followed up for a mean of 7 years and the association between BMI and FFMI and mortality was examined taking age, gender, smoking and lung function into account. Main results: The mean FFMI was 16.0 kg/m(2) for women and 18.7 kg/m(2) for men. Among subjects with normal BMI, 26.1 % had an FFMI lower than the lowest FFMI 10(th) percentile of the general population. BMI and FFMI were significant predictors of mortality, independent of relevant covariates. Being in the lowest FFMI 10(th) percentile of the general population was associated with a hazard ratio of 1.5 (95% confidence interval 1.2-1.8) for overall mortality and 2.4 (1.4-4.0) for COPD-related mortality. FFMI was also a predictor of overall mortality when analyses were restricted to subjects with normal BMI. Conclusions: FFMI provides information in addition to BMI and assessment of fat free mass should be considered in the routine assessment of COPD.

Original language	English
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	173
Issue number	1
Pages (from-to)	79-83
ISSN	1073-449X
Publication status	Published - 2006

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Vestbo, J., Prescott, E., Almdal, T. P., Dahl, M., Nordestgaard, B. G., Andersen, T., Sørensen, T. I. A., & Lange, P. (2006). Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study. American Journal of Respiratory and Critical Care Medicine, 173(1), 79-83. http://ajrccm.atsjournals.org/cgi/content/full/173/1/79?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=vestbo%2C+j&titleabstract=Body+Mass&searchid=1&FIRSTINDEX=0&volume=173&firstpage=79&fdate=1/1/2006&resourcetype=HWCIT

Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study. / Vestbo, Jørgen; Prescott, Eva; Almdal, Thomas Peter et al.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 173, No. 1, 2006, p. 79-83.

Research output: Contribution to journal › Journal article › Research › peer-review

Vestbo, J, Prescott, E, Almdal, TP, Dahl, M, Nordestgaard, BG, Andersen, T, Sørensen, TIA & Lange, P 2006, 'Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study.', American Journal of Respiratory and Critical Care Medicine, vol. 173, no. 1, pp. 79-83. <http://ajrccm.atsjournals.org/cgi/content/full/173/1/79?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=vestbo%2C+j&titleabstract=Body+Mass&searchid=1&FIRSTINDEX=0&volume=173&firstpage=79&fdate=1/1/2006&resourcetype=HWCIT>

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title = "Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study.",

abstract = "Rationale: Low body mass index (BMI) is a marker of poor prognosis in chronic obstructive pulmonary disease (COPD). In the general population the harmful effect of low BMI is due to the deleterious effects of a low fat free mass index (FFMI, fat free mass/weight(2)). Objectives: We explored distribution of low FFMI and its association with prognosis in a population based cohort of COPD patients. Methods: We used data on 1,898 COPD patients identified in a population-based epidemiological study in Copenhagen. Fat free mass was measured using bioelectrical impedance analysis. Patients were followed up for a mean of 7 years and the association between BMI and FFMI and mortality was examined taking age, gender, smoking and lung function into account. Main results: The mean FFMI was 16.0 kg/m(2) for women and 18.7 kg/m(2) for men. Among subjects with normal BMI, 26.1 % had an FFMI lower than the lowest FFMI 10(th) percentile of the general population. BMI and FFMI were significant predictors of mortality, independent of relevant covariates. Being in the lowest FFMI 10(th) percentile of the general population was associated with a hazard ratio of 1.5 (95% confidence interval 1.2-1.8) for overall mortality and 2.4 (1.4-4.0) for COPD-related mortality. FFMI was also a predictor of overall mortality when analyses were restricted to subjects with normal BMI. Conclusions: FFMI provides information in addition to BMI and assessment of fat free mass should be considered in the routine assessment of COPD.",

author = "J{\o}rgen Vestbo and Eva Prescott and Almdal, {Thomas Peter} and Morten Dahl and Nordestgaard, {B{\o}rge G.} and Teis Andersen and S{\o}rensen, {Thorkild I. A.} and Peter Lange",

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language = "English",

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T1 - Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study.

AU - Vestbo, Jørgen

AU - Prescott, Eva

AU - Almdal, Thomas Peter

AU - Dahl, Morten

AU - Nordestgaard, Børge G.

AU - Andersen, Teis

AU - Sørensen, Thorkild I. A.

AU - Lange, Peter

PY - 2006

Y1 - 2006

N2 - Rationale: Low body mass index (BMI) is a marker of poor prognosis in chronic obstructive pulmonary disease (COPD). In the general population the harmful effect of low BMI is due to the deleterious effects of a low fat free mass index (FFMI, fat free mass/weight(2)). Objectives: We explored distribution of low FFMI and its association with prognosis in a population based cohort of COPD patients. Methods: We used data on 1,898 COPD patients identified in a population-based epidemiological study in Copenhagen. Fat free mass was measured using bioelectrical impedance analysis. Patients were followed up for a mean of 7 years and the association between BMI and FFMI and mortality was examined taking age, gender, smoking and lung function into account. Main results: The mean FFMI was 16.0 kg/m(2) for women and 18.7 kg/m(2) for men. Among subjects with normal BMI, 26.1 % had an FFMI lower than the lowest FFMI 10(th) percentile of the general population. BMI and FFMI were significant predictors of mortality, independent of relevant covariates. Being in the lowest FFMI 10(th) percentile of the general population was associated with a hazard ratio of 1.5 (95% confidence interval 1.2-1.8) for overall mortality and 2.4 (1.4-4.0) for COPD-related mortality. FFMI was also a predictor of overall mortality when analyses were restricted to subjects with normal BMI. Conclusions: FFMI provides information in addition to BMI and assessment of fat free mass should be considered in the routine assessment of COPD.

AB - Rationale: Low body mass index (BMI) is a marker of poor prognosis in chronic obstructive pulmonary disease (COPD). In the general population the harmful effect of low BMI is due to the deleterious effects of a low fat free mass index (FFMI, fat free mass/weight(2)). Objectives: We explored distribution of low FFMI and its association with prognosis in a population based cohort of COPD patients. Methods: We used data on 1,898 COPD patients identified in a population-based epidemiological study in Copenhagen. Fat free mass was measured using bioelectrical impedance analysis. Patients were followed up for a mean of 7 years and the association between BMI and FFMI and mortality was examined taking age, gender, smoking and lung function into account. Main results: The mean FFMI was 16.0 kg/m(2) for women and 18.7 kg/m(2) for men. Among subjects with normal BMI, 26.1 % had an FFMI lower than the lowest FFMI 10(th) percentile of the general population. BMI and FFMI were significant predictors of mortality, independent of relevant covariates. Being in the lowest FFMI 10(th) percentile of the general population was associated with a hazard ratio of 1.5 (95% confidence interval 1.2-1.8) for overall mortality and 2.4 (1.4-4.0) for COPD-related mortality. FFMI was also a predictor of overall mortality when analyses were restricted to subjects with normal BMI. Conclusions: FFMI provides information in addition to BMI and assessment of fat free mass should be considered in the routine assessment of COPD.

M3 - Journal article

SN - 1073-449X

VL - 173

SP - 79

EP - 83

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

IS - 1

ER -

Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study.

Abstract

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