Biology and potential clinical implications of tissue inhibitor of metalloproteinases-1 in colorectal cancer treatment

TY - JOUR

T1 - Biology and potential clinical implications of tissue inhibitor of metalloproteinases-1 in colorectal cancer treatment

AU - Sørensen, Nanna Møller

AU - Sørensen, irene Vejgaard

AU - Würtz, Sidse Ørnbjerg

AU - Schrohl, Anne-Sofie

AU - Dowell, Barry

AU - Davis, Gerard

AU - Christensen, Ib Jarle

AU - Nielsen, Hans Jørgen

AU - Brünner, Nils

N1 - Keywords: Colorectal Neoplasms; Humans; Neoplasm, Residual; Prognosis; Survival Rate; Tissue Inhibitor of Metalloproteinase-1; Tumor Markers, Biological

PY - 2008/7/1

Y1 - 2008/7/1

N2 - Colorectal cancer (CRC) is the second leading cause of cancer-related death in the industrialized world. About half of "curatively" resected patients develop recurrent disease within the next 3-5 years despite the lack of clinical, histological and biochemical evidence of remaining overt disease after resection of the primary tumour. Availability of validated biological markers for early detection, selection for adjuvant therapy, prediction of treatment efficacy and monitoring of treatment efficacy would most probably increase survival. Tissue inhibitor of metalloproteinases-1 (TIMP-1) may be such a marker. TIMP-1 inhibits the proteolytic activity of metalloproteinases, which are centrally involved in tumour invasion and metastases. However, in clinical investigations high tumour tissue or plasma levels of TIMP-1 have shown a strong and independent association with a shorter survival time in CRC patients, suggesting that TIMP-1 could have a tumour-promoting function. Furthermore, measurement of plasma TIMP-1 has been shown to be useful for disease detection, with a high sensitivity and high specificity for early-stage colon cancer. This review describes some basic information on the current knowledge of the biology of TIMP-1 as well as the potential use of TIMP-1 as a biological marker in the management of CRC patients.

AB - Colorectal cancer (CRC) is the second leading cause of cancer-related death in the industrialized world. About half of "curatively" resected patients develop recurrent disease within the next 3-5 years despite the lack of clinical, histological and biochemical evidence of remaining overt disease after resection of the primary tumour. Availability of validated biological markers for early detection, selection for adjuvant therapy, prediction of treatment efficacy and monitoring of treatment efficacy would most probably increase survival. Tissue inhibitor of metalloproteinases-1 (TIMP-1) may be such a marker. TIMP-1 inhibits the proteolytic activity of metalloproteinases, which are centrally involved in tumour invasion and metastases. However, in clinical investigations high tumour tissue or plasma levels of TIMP-1 have shown a strong and independent association with a shorter survival time in CRC patients, suggesting that TIMP-1 could have a tumour-promoting function. Furthermore, measurement of plasma TIMP-1 has been shown to be useful for disease detection, with a high sensitivity and high specificity for early-stage colon cancer. This review describes some basic information on the current knowledge of the biology of TIMP-1 as well as the potential use of TIMP-1 as a biological marker in the management of CRC patients.

U2 - 10.1080/00365520701878163

DO - 10.1080/00365520701878163

M3 - Journal article

C2 - 18584515

SN - 0036-5521

VL - 43

SP - 774

EP - 786

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

IS - 7

ER -