TY - JOUR
T1 - Associations between vitamin D status in infants and blood lipids, body mass index and waist circumference
AU - Arnberg, Karina
AU - Østergård, Mathilde
AU - Madsen, Anja Lykke
AU - Krarup, Henrik Bygum
AU - Michaelsen, Kim F.
AU - Mølgaard, Christian
PY - 2011/9
Y1 - 2011/9
N2 - Aim: To study the relationships between 25-hydroxyvitamin D status and blood lipids, insulin, glucose, body mass index and waist circumference in infants. Methods: In a cross-sectional study, 255 infants aged 9 months with a blood sample for 25-hydroxyvitamin D were examined. Plasma 25-hydroxyvitamin D concentrations were analysed by chemiluminescent immunoassay. Associations between plasma 25-hydroxyvitamin D and high-density lipoprotein (HDL), low-density lipoprotein, total cholesterol, triglycerides, insulin, glucose, body mass index and waist circumference were analysed. Results: Mean plasma 25-hydroxyvitamin D was 77.2 ± 22.7 nM. At the time of examination, 97% received vitamin D supplementation. 25-Hydroxyvitamin D was negatively associated with HDL (p = 0.003), cholesterol (p = 0.002) and triglycerides (p = 0.010) in multivariate analysis controlled for gender, season, body mass index, length, birth weight and breastfeeding. There were no associations between 25-hydroxyvitamin D and glucose or insulin (all p > 0.05). 25-hydroxyvitamin D was negatively associated with body mass index (p = 0.005) and waist circumference (p = 0.002) controlled for gender, season, breastfeeding, birth weight and length. Conclusion: Vitamin D status is negatively associated with blood lipids, body mass index and waist circumference in infants where nearly all received vitamin D supplements. Whether this has long-term health effects remains to be elucidated.
AB - Aim: To study the relationships between 25-hydroxyvitamin D status and blood lipids, insulin, glucose, body mass index and waist circumference in infants. Methods: In a cross-sectional study, 255 infants aged 9 months with a blood sample for 25-hydroxyvitamin D were examined. Plasma 25-hydroxyvitamin D concentrations were analysed by chemiluminescent immunoassay. Associations between plasma 25-hydroxyvitamin D and high-density lipoprotein (HDL), low-density lipoprotein, total cholesterol, triglycerides, insulin, glucose, body mass index and waist circumference were analysed. Results: Mean plasma 25-hydroxyvitamin D was 77.2 ± 22.7 nM. At the time of examination, 97% received vitamin D supplementation. 25-Hydroxyvitamin D was negatively associated with HDL (p = 0.003), cholesterol (p = 0.002) and triglycerides (p = 0.010) in multivariate analysis controlled for gender, season, body mass index, length, birth weight and breastfeeding. There were no associations between 25-hydroxyvitamin D and glucose or insulin (all p > 0.05). 25-hydroxyvitamin D was negatively associated with body mass index (p = 0.005) and waist circumference (p = 0.002) controlled for gender, season, breastfeeding, birth weight and length. Conclusion: Vitamin D status is negatively associated with blood lipids, body mass index and waist circumference in infants where nearly all received vitamin D supplements. Whether this has long-term health effects remains to be elucidated.
U2 - 10.1111/j.1651-2227.2011.02273.x
DO - 10.1111/j.1651-2227.2011.02273.x
M3 - Journal article
C2 - 21418102
SN - 0803-5253
VL - 100
SP - 1244
EP - 1248
JO - Acta Paediatrica, International Journal of Paediatrics, Supplement
JF - Acta Paediatrica, International Journal of Paediatrics, Supplement
IS - 9
ER -