Abstract
Background: Obesity is linked to asthma in a yet poorly understood manner. We examined the relationship between obesity and asthma in a population-based sample of twins.
Methods: From the cohorts born between 1953 and 1982, who were enrolled in The Danish Twin Registry, a total of 29 183 twin individuals participated in a nationwide questionnaire study, where data on height, weight and asthma were collected. Latent factor models of genetic and environmental effects were fitted using maximum likelihood methods.
Results: The age-adjusted risk of asthma was increased both in obese females, OR = 1.96 (1.45-2.64), P = 0.001 and in obese males, OR = 1.59 (1.08-2.33), P = 0.02. According to best-fitting models, the heritability for obesity was 81% in males and 92% in females, whereas the heritability for asthma was 78% and 68% in males and females respectively. The age-adjusted genetic liabilities to obesity and asthma were significantly correlated only in females, r = 0.28 (0.16-0.38).
Conclusions: Obese subjects have an increased risk for asthma, which in females seems partly because of common genes.
| Original language | English |
|---|---|
| Journal | Allergy. European Journal of Allergy and Clinical Immunology |
| Volume | 62 |
| Issue number | 10 |
| Pages (from-to) | 1199-1204 |
| Number of pages | 5 |
| ISSN | 0105-4538 |
| DOIs | |
| Publication status | Published - 2007 |
