An antileishmanial chalcone from Chinese licorice roots

S B Christensen; C Ming; L Andersen; U Hjørne; C E Olsen; C Cornett; T G Theander; A Kharazmi

An antileishmanial chalcone from Chinese licorice roots

S B Christensen, C Ming, L Andersen, U Hjørne, C E Olsen, C Cornett, T G Theander, A Kharazmi

35 Citations (Scopus)

Abstract

A bioassay guided fractionation of an extract of Chinese licorice roots led to the isolation of (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-[4- hydroxy-3-(3-methyl-2-butenyl]phenyl-2-propen-1-one, which in vitro showed potent antileishmanial activity. In addition, the novel chalcone (E)-1-[2,4-dihydroxy-3-(3-methyl-2- butenyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)-2-prope n-1-one was isolated from the roots. The latter compound only showed antileishmanial activity at high concentrations.

Original language	English
Journal	Planta Medica
Volume	60
Issue number	2
Pages (from-to)	121-3
Number of pages	2
ISSN	0032-0943
Publication status	Published - 1994

Cite this

@article{cd410cd0a0da11dd86a6000ea68e967b,

title = "An antileishmanial chalcone from Chinese licorice roots",

abstract = "A bioassay guided fractionation of an extract of Chinese licorice roots led to the isolation of (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-[4- hydroxy-3-(3-methyl-2-butenyl]phenyl-2-propen-1-one, which in vitro showed potent antileishmanial activity. In addition, the novel chalcone (E)-1-[2,4-dihydroxy-3-(3-methyl-2- butenyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)-2-prope n-1-one was isolated from the roots. The latter compound only showed antileishmanial activity at high concentrations.",

author = "Christensen, {S B} and C Ming and L Andersen and U Hj{\o}rne and Olsen, {C E} and C Cornett and Theander, {T G} and A Kharazmi",

note = "Keywords: Animals; Antiprotozoal Agents; Chalcone; Chalcones; China; Glycyrrhiza; Leishmania donovani; Magnetic Resonance Spectroscopy; Molecular Structure; Plants, Medicinal",

year = "1994",

language = "English",

volume = "60",

pages = "121--3",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "GeorgThieme Verlag",

number = "2",

}

TY - JOUR

T1 - An antileishmanial chalcone from Chinese licorice roots

AU - Christensen, S B

AU - Ming, C

AU - Andersen, L

AU - Hjørne, U

AU - Olsen, C E

AU - Cornett, C

AU - Theander, T G

AU - Kharazmi, A

N1 - Keywords: Animals; Antiprotozoal Agents; Chalcone; Chalcones; China; Glycyrrhiza; Leishmania donovani; Magnetic Resonance Spectroscopy; Molecular Structure; Plants, Medicinal

PY - 1994

Y1 - 1994

N2 - A bioassay guided fractionation of an extract of Chinese licorice roots led to the isolation of (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-[4- hydroxy-3-(3-methyl-2-butenyl]phenyl-2-propen-1-one, which in vitro showed potent antileishmanial activity. In addition, the novel chalcone (E)-1-[2,4-dihydroxy-3-(3-methyl-2- butenyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)-2-prope n-1-one was isolated from the roots. The latter compound only showed antileishmanial activity at high concentrations.

AB - A bioassay guided fractionation of an extract of Chinese licorice roots led to the isolation of (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-[4- hydroxy-3-(3-methyl-2-butenyl]phenyl-2-propen-1-one, which in vitro showed potent antileishmanial activity. In addition, the novel chalcone (E)-1-[2,4-dihydroxy-3-(3-methyl-2- butenyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)-2-prope n-1-one was isolated from the roots. The latter compound only showed antileishmanial activity at high concentrations.

M3 - Journal article

C2 - 8202561

SN - 0032-0943

VL - 60

SP - 121

EP - 123

JO - Planta Medica

JF - Planta Medica

IS - 2

ER -

An antileishmanial chalcone from Chinese licorice roots

Abstract

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