Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up

Juan P Arrebola; Mariana F Fernández; Piedad Martín-Olmedo; José Manuel Molina-Molina; María J Sánchez-Pérez; Emilio Sánchez-Cantalejo; Elena Molina-Portillo; José Expósito; Jens Peter Bonde; Nicolás Olea

doi:10.1016/j.scitotenv.2014.08.043

Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up

Juan P Arrebola, Mariana F Fernández, Piedad Martín-Olmedo, José Manuel Molina-Molina, María J Sánchez-Pérez, Emilio Sánchez-Cantalejo, Elena Molina-Portillo, José Expósito, Jens Peter Bonde, Nicolás Olea

21 Citations (Scopus)

Abstract

There is an increasing trend in the incidence of cancer worldwide, and it has been accepted that environmental factors account for an important proportion of the global burden. The present paper reports preliminary findings on the influence of the historical exposure to a group of persistent organic pollutants on total cancer risk, at year 9 in the follow-up of a cohort from Southern Spain. A cohort of 368 participants (median age 51 years) was recruited in 2003. Their historical exposure was estimated by analyzing residues of persistent organic pollutants in adipose tissue. Estimation of cancer incidence was based on data from a population-based cancer registry. Statistical analyses were performed using multivariable Cox-regression models. In males, PCB 153 concentrations were positively associated with total cancer risk, with an adjusted hazard ratio (95% confidence interval) of 1.20 (1.01-1.41) for an increment of 100 ng/g lipid. Our preliminary findings suggest a potential relationship between the historical exposure to persistent organic pollutants and the risk of cancer in men. However, these results should be interpreted with caution and require verification during the future follow-up of this cohort.

Original language	English
Journal	The Science of the Total Environment
Volume	500-501
Pages (from-to)	243-249
Number of pages	7
ISSN	0048-9697
DOIs	https://doi.org/10.1016/j.scitotenv.2014.08.043
Publication status	Published - 1 Dec 2014

Keywords

Adipose Tissue
Adult
Environmental Exposure
Environmental Pollutants
Follow-Up Studies
Hazardous Substances
Humans
Male
Middle Aged
Neoplasms
Regression Analysis
Spain

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.scitotenv.2014.08.043

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Arrebola, J. P., Fernández, M. F., Martín-Olmedo, P., Molina-Molina, J. M., Sánchez-Pérez, M. J., Sánchez-Cantalejo, E., Molina-Portillo, E., Expósito, J., Bonde, J. P., & Olea, N. (2014). Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up. The Science of the Total Environment, 500-501, 243-249. https://doi.org/10.1016/j.scitotenv.2014.08.043

Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain : Preliminary data from year 9 of the follow-up. / Arrebola, Juan P; Fernández, Mariana F; Martín-Olmedo, Piedad et al.

In: The Science of the Total Environment, Vol. 500-501, 01.12.2014, p. 243-249.

Research output: Contribution to journal › Journal article › Research › peer-review

Arrebola, JP, Fernández, MF, Martín-Olmedo, P, Molina-Molina, JM, Sánchez-Pérez, MJ, Sánchez-Cantalejo, E, Molina-Portillo, E, Expósito, J, Bonde, JP & Olea, N 2014, 'Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up', The Science of the Total Environment, vol. 500-501, pp. 243-249. https://doi.org/10.1016/j.scitotenv.2014.08.043

Arrebola JP, Fernández MF, Martín-Olmedo P, Molina-Molina JM, Sánchez-Pérez MJ, Sánchez-Cantalejo E et al. Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up. The Science of the Total Environment. 2014 Dec 1;500-501:243-249. doi: 10.1016/j.scitotenv.2014.08.043

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abstract = "There is an increasing trend in the incidence of cancer worldwide, and it has been accepted that environmental factors account for an important proportion of the global burden. The present paper reports preliminary findings on the influence of the historical exposure to a group of persistent organic pollutants on total cancer risk, at year 9 in the follow-up of a cohort from Southern Spain. A cohort of 368 participants (median age 51 years) was recruited in 2003. Their historical exposure was estimated by analyzing residues of persistent organic pollutants in adipose tissue. Estimation of cancer incidence was based on data from a population-based cancer registry. Statistical analyses were performed using multivariable Cox-regression models. In males, PCB 153 concentrations were positively associated with total cancer risk, with an adjusted hazard ratio (95% confidence interval) of 1.20 (1.01-1.41) for an increment of 100 ng/g lipid. Our preliminary findings suggest a potential relationship between the historical exposure to persistent organic pollutants and the risk of cancer in men. However, these results should be interpreted with caution and require verification during the future follow-up of this cohort.",

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AU - Sánchez-Pérez, María J

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AU - Bonde, Jens Peter

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N2 - There is an increasing trend in the incidence of cancer worldwide, and it has been accepted that environmental factors account for an important proportion of the global burden. The present paper reports preliminary findings on the influence of the historical exposure to a group of persistent organic pollutants on total cancer risk, at year 9 in the follow-up of a cohort from Southern Spain. A cohort of 368 participants (median age 51 years) was recruited in 2003. Their historical exposure was estimated by analyzing residues of persistent organic pollutants in adipose tissue. Estimation of cancer incidence was based on data from a population-based cancer registry. Statistical analyses were performed using multivariable Cox-regression models. In males, PCB 153 concentrations were positively associated with total cancer risk, with an adjusted hazard ratio (95% confidence interval) of 1.20 (1.01-1.41) for an increment of 100 ng/g lipid. Our preliminary findings suggest a potential relationship between the historical exposure to persistent organic pollutants and the risk of cancer in men. However, these results should be interpreted with caution and require verification during the future follow-up of this cohort.

AB - There is an increasing trend in the incidence of cancer worldwide, and it has been accepted that environmental factors account for an important proportion of the global burden. The present paper reports preliminary findings on the influence of the historical exposure to a group of persistent organic pollutants on total cancer risk, at year 9 in the follow-up of a cohort from Southern Spain. A cohort of 368 participants (median age 51 years) was recruited in 2003. Their historical exposure was estimated by analyzing residues of persistent organic pollutants in adipose tissue. Estimation of cancer incidence was based on data from a population-based cancer registry. Statistical analyses were performed using multivariable Cox-regression models. In males, PCB 153 concentrations were positively associated with total cancer risk, with an adjusted hazard ratio (95% confidence interval) of 1.20 (1.01-1.41) for an increment of 100 ng/g lipid. Our preliminary findings suggest a potential relationship between the historical exposure to persistent organic pollutants and the risk of cancer in men. However, these results should be interpreted with caution and require verification during the future follow-up of this cohort.

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KW - Adult

KW - Environmental Exposure

KW - Environmental Pollutants

KW - Follow-Up Studies

KW - Hazardous Substances

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoplasms

KW - Regression Analysis

KW - Spain

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DO - 10.1016/j.scitotenv.2014.08.043

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SN - 0048-9697

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JF - Science of the Total Environment

ER -

Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up

Abstract

Keywords

UN SDGs

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