Acute hypoxia and cytochrome P450-mediated hepatic drug metabolism in humans

Gesche Jürgens; Hanne Rolighed Christensen; Kim Brøsen; Jesper Sonne; Steffen Loft; Niels Vidiendal Olsen

doi:10.1067/mcp.2002.121789

Acute hypoxia and cytochrome P450-mediated hepatic drug metabolism in humans

Gesche Jürgens, Hanne Rolighed Christensen, Kim Brøsen, Jesper Sonne, Steffen Loft, Niels Vidiendal Olsen

51 Citations (Scopus)

Abstract

Our objective was to investigate the effect of acute hypoxia on the activity of hepatic cytochrome P450 (CYP) enzymes.

Original language	English
Journal	Clinical Pharmacology and Therapeutics
Volume	71
Issue number	4
Pages (from-to)	214-20
Number of pages	7
ISSN	0009-9236
DOIs	https://doi.org/10.1067/mcp.2002.121789
Publication status	Published - Apr 2002

Keywords

Acute Disease
Adult
Altitude
Anoxia
Caffeine
Cytochrome P-450 Enzyme System
Female
Humans
Hydrocortisone
Liver
Longitudinal Studies
Male
Mephenytoin
Sparteine
Statistics, Nonparametric

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10.1067/mcp.2002.121789

Cite this

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title = "Acute hypoxia and cytochrome P450-mediated hepatic drug metabolism in humans",

abstract = "Our objective was to investigate the effect of acute hypoxia on the activity of hepatic cytochrome P450 (CYP) enzymes.",

keywords = "Acute Disease, Adult, Altitude, Anoxia, Caffeine, Cytochrome P-450 Enzyme System, Female, Humans, Hydrocortisone, Liver, Longitudinal Studies, Male, Mephenytoin, Sparteine, Statistics, Nonparametric",

author = "Gesche J{\"u}rgens and Christensen, {Hanne Rolighed} and Kim Br{\o}sen and Jesper Sonne and Steffen Loft and Olsen, {Niels Vidiendal}",

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AU - Jürgens, Gesche

AU - Christensen, Hanne Rolighed

AU - Brøsen, Kim

AU - Sonne, Jesper

AU - Loft, Steffen

AU - Olsen, Niels Vidiendal

PY - 2002/4

Y1 - 2002/4

N2 - Our objective was to investigate the effect of acute hypoxia on the activity of hepatic cytochrome P450 (CYP) enzymes.

AB - Our objective was to investigate the effect of acute hypoxia on the activity of hepatic cytochrome P450 (CYP) enzymes.

KW - Acute Disease

KW - Adult

KW - Altitude

KW - Anoxia

KW - Caffeine

KW - Cytochrome P-450 Enzyme System

KW - Female

KW - Humans

KW - Hydrocortisone

KW - Liver

KW - Longitudinal Studies

KW - Male

KW - Mephenytoin

KW - Sparteine

KW - Statistics, Nonparametric

U2 - 10.1067/mcp.2002.121789

DO - 10.1067/mcp.2002.121789

M3 - Journal article

C2 - 11956503

SN - 0009-9236

VL - 71

SP - 214

EP - 220

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

IS - 4

ER -

Acute hypoxia and cytochrome P450-mediated hepatic drug metabolism in humans

Abstract

Keywords

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