Acute effects of casein on postprandial lipemia and incretin responses in type 2 diabetic subjects

Lea Johanne Brader; L. Holm; L. Mortensen; C. Thomsen; Arne Astrup; Jens Juul Holst; M. de Vrese; J. Schrezenmeir; Kjeld Hermansen

doi:10.1016/j.numecd.2009.03.019

Acute effects of casein on postprandial lipemia and incretin responses in type 2 diabetic subjects

Lea Johanne Brader, L. Holm, L. Mortensen, C. Thomsen, Arne Astrup, Jens Juul Holst, M. de Vrese, J. Schrezenmeir, Kjeld Hermansen

20 Citations (Scopus)

Abstract

Background and aims: Exaggerated and prolonged postprandial lipemia is potentially atherogenic and associated with type 2 diabetes. Limited data exist regarding the influence of dietary protein on postprandial lipemia in type 2 diabetes. We investigated, over 8-h, the acute effects of casein alone or in combination with carbohydrate on postprandial lipid and incretin responses to a fat-rich meal in type 2 diabetes. Methods and results: Eleven type 2 diabetic subjects ingested four test meals in random order: an energy-free soup plus 80 g of fat (control-meal); control-meal plus 45 g carbohydrates (CHO-meal); control-meal plus 45 g of casein (PRO-meal); and PRO-meal plus 45 g carbohydrates (CHO + PRO-meal). Triglyceride and retinyl palmitate responses were measured in plasma and in a chylomicron-rich and chylomicron-poor fraction. We found no significant differences in triglyceride responses to PRO- and CHO + PRO-meal compared to the control-meal. However, the addition of casein to the CHO-meal reduced the raised triglyceride response in the chylomicron-rich fraction. Retinyl palmitate responses did not differ significantly between meals in the chylomicron-rich fraction, whereas the PRO-meal increased retinyl palmitate in the chylomicron-poor fraction. PRO- and PRO + CHO-meal increased insulin and glucagon compared to the control-meal. PRO + CHO-meal increased the glucose-dependent insulinotropic peptide response while no change in glucagon-like peptide-1 responses was detected. Conclusions: The data presented suggest that casein per se did not modulate the postprandial triglyceride response in type 2 diabetes. When added to carbohydrate, casein suppressed the triglyceride response in the chylomicron-rich fraction, increased insulin and glucagon but did not affect the incretin responses.

Original language	English
Journal	Nutrition, Metabolism & Cardiovascular Diseases
Volume	20
Issue number	2
Pages (from-to)	101-109
Number of pages	9
ISSN	0939-4753
DOIs	https://doi.org/10.1016/j.numecd.2009.03.019
Publication status	Published - Feb 2010

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10.1016/j.numecd.2009.03.019

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@article{8e2451805b3611dea8de000ea68e967b,

title = "Acute effects of casein on postprandial lipemia and incretin responses in type 2 diabetic subjects",

abstract = "Background and aims: Exaggerated and prolonged postprandial lipemia is potentially atherogenic and associated with type 2 diabetes. Limited data exist regarding the influence of dietary protein on postprandial lipemia in type 2 diabetes. We investigated, over 8-h, the acute effects of casein alone or in combination with carbohydrate on postprandial lipid and incretin responses to a fat-rich meal in type 2 diabetes. Methods and results: Eleven type 2 diabetic subjects ingested four test meals in random order: an energy-free soup plus 80 g of fat (control-meal); control-meal plus 45 g carbohydrates (CHO-meal); control-meal plus 45 g of casein (PRO-meal); and PRO-meal plus 45 g carbohydrates (CHO + PRO-meal). Triglyceride and retinyl palmitate responses were measured in plasma and in a chylomicron-rich and chylomicron-poor fraction. We found no significant differences in triglyceride responses to PRO- and CHO + PRO-meal compared to the control-meal. However, the addition of casein to the CHO-meal reduced the raised triglyceride response in the chylomicron-rich fraction. Retinyl palmitate responses did not differ significantly between meals in the chylomicron-rich fraction, whereas the PRO-meal increased retinyl palmitate in the chylomicron-poor fraction. PRO- and PRO + CHO-meal increased insulin and glucagon compared to the control-meal. PRO + CHO-meal increased the glucose-dependent insulinotropic peptide response while no change in glucagon-like peptide-1 responses was detected. Conclusions: The data presented suggest that casein per se did not modulate the postprandial triglyceride response in type 2 diabetes. When added to carbohydrate, casein suppressed the triglyceride response in the chylomicron-rich fraction, increased insulin and glucagon but did not affect the incretin responses.",

author = "Brader, {Lea Johanne} and L. Holm and L. Mortensen and C. Thomsen and Arne Astrup and Holst, {Jens Juul} and Vrese, {M. de} and J. Schrezenmeir and Kjeld Hermansen",

year = "2010",

month = feb,

doi = "10.1016/j.numecd.2009.03.019",

language = "English",

volume = "20",

pages = "101--109",

journal = "Nutrition, Metabolism & Cardiovascular Diseases",

issn = "0939-4753",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Acute effects of casein on postprandial lipemia and incretin responses in type 2 diabetic subjects

AU - Brader, Lea Johanne

AU - Holm, L.

AU - Mortensen, L.

AU - Thomsen, C.

AU - Astrup, Arne

AU - Holst, Jens Juul

AU - Vrese, M. de

AU - Schrezenmeir, J.

AU - Hermansen, Kjeld

PY - 2010/2

Y1 - 2010/2

N2 - Background and aims: Exaggerated and prolonged postprandial lipemia is potentially atherogenic and associated with type 2 diabetes. Limited data exist regarding the influence of dietary protein on postprandial lipemia in type 2 diabetes. We investigated, over 8-h, the acute effects of casein alone or in combination with carbohydrate on postprandial lipid and incretin responses to a fat-rich meal in type 2 diabetes. Methods and results: Eleven type 2 diabetic subjects ingested four test meals in random order: an energy-free soup plus 80 g of fat (control-meal); control-meal plus 45 g carbohydrates (CHO-meal); control-meal plus 45 g of casein (PRO-meal); and PRO-meal plus 45 g carbohydrates (CHO + PRO-meal). Triglyceride and retinyl palmitate responses were measured in plasma and in a chylomicron-rich and chylomicron-poor fraction. We found no significant differences in triglyceride responses to PRO- and CHO + PRO-meal compared to the control-meal. However, the addition of casein to the CHO-meal reduced the raised triglyceride response in the chylomicron-rich fraction. Retinyl palmitate responses did not differ significantly between meals in the chylomicron-rich fraction, whereas the PRO-meal increased retinyl palmitate in the chylomicron-poor fraction. PRO- and PRO + CHO-meal increased insulin and glucagon compared to the control-meal. PRO + CHO-meal increased the glucose-dependent insulinotropic peptide response while no change in glucagon-like peptide-1 responses was detected. Conclusions: The data presented suggest that casein per se did not modulate the postprandial triglyceride response in type 2 diabetes. When added to carbohydrate, casein suppressed the triglyceride response in the chylomicron-rich fraction, increased insulin and glucagon but did not affect the incretin responses.

AB - Background and aims: Exaggerated and prolonged postprandial lipemia is potentially atherogenic and associated with type 2 diabetes. Limited data exist regarding the influence of dietary protein on postprandial lipemia in type 2 diabetes. We investigated, over 8-h, the acute effects of casein alone or in combination with carbohydrate on postprandial lipid and incretin responses to a fat-rich meal in type 2 diabetes. Methods and results: Eleven type 2 diabetic subjects ingested four test meals in random order: an energy-free soup plus 80 g of fat (control-meal); control-meal plus 45 g carbohydrates (CHO-meal); control-meal plus 45 g of casein (PRO-meal); and PRO-meal plus 45 g carbohydrates (CHO + PRO-meal). Triglyceride and retinyl palmitate responses were measured in plasma and in a chylomicron-rich and chylomicron-poor fraction. We found no significant differences in triglyceride responses to PRO- and CHO + PRO-meal compared to the control-meal. However, the addition of casein to the CHO-meal reduced the raised triglyceride response in the chylomicron-rich fraction. Retinyl palmitate responses did not differ significantly between meals in the chylomicron-rich fraction, whereas the PRO-meal increased retinyl palmitate in the chylomicron-poor fraction. PRO- and PRO + CHO-meal increased insulin and glucagon compared to the control-meal. PRO + CHO-meal increased the glucose-dependent insulinotropic peptide response while no change in glucagon-like peptide-1 responses was detected. Conclusions: The data presented suggest that casein per se did not modulate the postprandial triglyceride response in type 2 diabetes. When added to carbohydrate, casein suppressed the triglyceride response in the chylomicron-rich fraction, increased insulin and glucagon but did not affect the incretin responses.

U2 - 10.1016/j.numecd.2009.03.019

DO - 10.1016/j.numecd.2009.03.019

M3 - Journal article

C2 - 19473824

SN - 0939-4753

VL - 20

SP - 101

EP - 109

JO - Nutrition, Metabolism & Cardiovascular Diseases

JF - Nutrition, Metabolism & Cardiovascular Diseases

IS - 2

ER -

Acute effects of casein on postprandial lipemia and incretin responses in type 2 diabetic subjects

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