Absorption tuning of the green fluorescent protein chromophore: synthesis and studies of model compounds

Mogens Brøndsted Nielsen; Lars H. Andersen; Tomás Rocha-Rinza

Absorption tuning of the green fluorescent protein chromophore: synthesis and studies of model compounds

Mogens Brøndsted Nielsen, Lars H. Andersen, Tomás Rocha-Rinza

Department of Chemistry

4 Citations (Scopus)

Abstract

The green fluorescent protein (GFP) chromophore is a heterocyclic compound containing a p-hydroxybenzylidine attached to an imidazol-5(4H)-one ring. This review covers the synthesis of a variety of model systems for elucidating the intrinsic optical properties of the chromophore in the gas phase and its response in particular to hydrogen bond interactions. The overall goal is to understand how the protein binding pocket influences the absorption behavior, and the current status of our ongoing efforts is presented.

Original language	English
Journal	Monatshefte fuer Chemie
Volume	142
Pages (from-to)	709-715
ISSN	0026-9247
Publication status	Published - Jul 2011

Cite this

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title = "Absorption tuning of the green fluorescent protein chromophore: synthesis and studies of model compounds",

abstract = "The green fluorescent protein (GFP) chromophore is a heterocyclic compound containing a p-hydroxybenzylidine attached to an imidazol-5(4H)-one ring. This review covers the synthesis of a variety of model systems for elucidating the intrinsic optical properties of the chromophore in the gas phase and its response in particular to hydrogen bond interactions. The overall goal is to understand how the protein binding pocket influences the absorption behavior, and the current status of our ongoing efforts is presented.",

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AU - Nielsen, Mogens Brøndsted

AU - Andersen, Lars H.

AU - Rocha-Rinza, Tomás

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N2 - The green fluorescent protein (GFP) chromophore is a heterocyclic compound containing a p-hydroxybenzylidine attached to an imidazol-5(4H)-one ring. This review covers the synthesis of a variety of model systems for elucidating the intrinsic optical properties of the chromophore in the gas phase and its response in particular to hydrogen bond interactions. The overall goal is to understand how the protein binding pocket influences the absorption behavior, and the current status of our ongoing efforts is presented.

AB - The green fluorescent protein (GFP) chromophore is a heterocyclic compound containing a p-hydroxybenzylidine attached to an imidazol-5(4H)-one ring. This review covers the synthesis of a variety of model systems for elucidating the intrinsic optical properties of the chromophore in the gas phase and its response in particular to hydrogen bond interactions. The overall goal is to understand how the protein binding pocket influences the absorption behavior, and the current status of our ongoing efforts is presented.

M3 - Journal article

SN - 0026-9247

VL - 142

SP - 709

EP - 715

JO - Monatshefte fur Chemie

JF - Monatshefte fur Chemie

ER -

Absorption tuning of the green fluorescent protein chromophore: synthesis and studies of model compounds

Abstract

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