A competing risks approach to "biologic" interaction

Per Kragh Andersen; Anders Skrondal

doi:10.1007/s10985-015-9318-z

A competing risks approach to "biologic" interaction

Per Kragh Andersen, Anders Skrondal

Section of Biostatistics

7 Citations (Scopus)

Abstract

In epidemiology, the concepts of "biologic" and "statistical" interactions have been the subject of extensive debate. We present a new approach to biologic interaction based on Rothman's original (Am J Epidemiol, 104:587-592, 1976) discussion of sufficient causes. We do this in a probabilistic framework using competing risks and argue that sufficient cause interaction between two factors can be evaluated via the parameters in a particular statistical model, the additive hazard rate model. We present empirical conditions for presence of sufficient cause interaction and an example based on data from a liver cirrhosis trial illustrates the ideas.

Original language	English
Journal	Lifetime Data Analysis
Volume	21
Issue number	2
Pages (from-to)	300-314
Number of pages	15
ISSN	1380-7870
DOIs	https://doi.org/10.1007/s10985-015-9318-z
Publication status	Published - Apr 2015

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AB - In epidemiology, the concepts of "biologic" and "statistical" interactions have been the subject of extensive debate. We present a new approach to biologic interaction based on Rothman's original (Am J Epidemiol, 104:587-592, 1976) discussion of sufficient causes. We do this in a probabilistic framework using competing risks and argue that sufficient cause interaction between two factors can be evaluated via the parameters in a particular statistical model, the additive hazard rate model. We present empirical conditions for presence of sufficient cause interaction and an example based on data from a liver cirrhosis trial illustrates the ideas.

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A competing risks approach to "biologic" interaction

Abstract

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