4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists

Jean-Marie Receveur; Emelie Bjurling; Trond Ulven; Paul Brian Little; Pia K Nørregaard; Thomas Högberg

doi:10.1016/j.bmcl.2004.07.077

4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists

Jean-Marie Receveur, Emelie Bjurling, Trond Ulven, Paul Brian Little, Pia K Nørregaard, Thomas Högberg

46 Citations (Scopus)

Abstract

Synthesis, in vitro biological evaluation and structure-activity relationships of 4-acylamino-and 4-ureidobenzamides as novel hMCH1R-antagonists are disclosed. The nature of the amine side chains could be varied considerably in contrast to the central benzamide scaffold and aromatic substituents.

Original language	English
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	14
Issue number	20
Pages (from-to)	5075-5080
Number of pages	6
ISSN	0960-894X
DOIs	https://doi.org/10.1016/j.bmcl.2004.07.077
Publication status	Published - 18 Oct 2004

Keywords

Animals
Benzamides
CHO Cells
Cricetinae
Cricetulus
Humans
Hypothalamic Hormones
Ligands
Melanins
Pituitary Hormones
Radioligand Assay
Receptors, Pituitary Hormone
Structure-Activity Relationship
Urea

Access to Document

10.1016/j.bmcl.2004.07.077

Cite this

@article{282902067a314b6c8e899c1343ac7fb5,

title = "4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists",

abstract = "Synthesis, in vitro biological evaluation and structure-activity relationships of 4-acylamino-and 4-ureidobenzamides as novel hMCH1R-antagonists are disclosed. The nature of the amine side chains could be varied considerably in contrast to the central benzamide scaffold and aromatic substituents.",

keywords = "Animals, Benzamides, CHO Cells, Cricetinae, Cricetulus, Humans, Hypothalamic Hormones, Ligands, Melanins, Pituitary Hormones, Radioligand Assay, Receptors, Pituitary Hormone, Structure-Activity Relationship, Urea",

author = "Jean-Marie Receveur and Emelie Bjurling and Trond Ulven and Little, {Paul Brian} and N{\o}rregaard, {Pia K} and Thomas H{\"o}gberg",

year = "2004",

month = oct,

day = "18",

doi = "10.1016/j.bmcl.2004.07.077",

language = "English",

volume = "14",

pages = "5075--5080",

journal = "Bioorganic & Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Pergamon Press",

number = "20",

}

TY - JOUR

T1 - 4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists

AU - Receveur, Jean-Marie

AU - Bjurling, Emelie

AU - Ulven, Trond

AU - Little, Paul Brian

AU - Nørregaard, Pia K

AU - Högberg, Thomas

PY - 2004/10/18

Y1 - 2004/10/18

N2 - Synthesis, in vitro biological evaluation and structure-activity relationships of 4-acylamino-and 4-ureidobenzamides as novel hMCH1R-antagonists are disclosed. The nature of the amine side chains could be varied considerably in contrast to the central benzamide scaffold and aromatic substituents.

AB - Synthesis, in vitro biological evaluation and structure-activity relationships of 4-acylamino-and 4-ureidobenzamides as novel hMCH1R-antagonists are disclosed. The nature of the amine side chains could be varied considerably in contrast to the central benzamide scaffold and aromatic substituents.

KW - Animals

KW - Benzamides

KW - CHO Cells

KW - Cricetinae

KW - Cricetulus

KW - Humans

KW - Hypothalamic Hormones

KW - Ligands

KW - Melanins

KW - Pituitary Hormones

KW - Radioligand Assay

KW - Receptors, Pituitary Hormone

KW - Structure-Activity Relationship

KW - Urea

U2 - 10.1016/j.bmcl.2004.07.077

DO - 10.1016/j.bmcl.2004.07.077

M3 - Journal article

SN - 0960-894X

VL - 14

SP - 5075

EP - 5080

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 20

ER -

4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists

Abstract

Keywords

Access to Document

Fingerprint

Cite this