Peter E. Nielsen

Research output

Research output per year 1975 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2019

• 339 Journal article
• 24 Book chapter
• 20 Report chapter
• 19 Review
• 13 More
  • 3 Book
  • 3 Comment/debate
  • 2 Conference abstract in journal
  • 2 Working paper
  • 1 Compendium/lecture notes
  • 1 Conference abstract for conference
  • 1 Poster

Research output per year

Research output per year

Search results

• 2010

  A maternal low protein diet has pronounced effects on mitochondrial gene expression in offspring liver and skeletal muscle; protective effect of taurine

  Mortensen, O. H., Olsen, H. L., Frandsen, L., Nielsen, P. E., Nielsen, F. C., Grunnet, N. & Quistorff, B., 1 Aug 2010, In: Journal of Biomedical Science. 24, 17, p. 1-11

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Protein-Restricted Diet 100%
  • Mitochondrial Genes 95%
  • Taurine 93%
  • Protective 62%
  • Skeletal Muscle 59%
  35 Citations (Scopus)

• Cellular delivery and antisense effects of peptide nucleic acid conjugated to polyethyleneimine via disulfide linkers

  Berthold, P. R., Shiraishi, T. & Nielsen, P. E., 20 Oct 2010, In: Bioconjugate Chemistry. 21, 10, p. 1933-8 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Peptide Nucleic Acids 100%
  • Polyethyleneimine 62%
  • Peptide Nucleic Acid 58%
  • Disulfides 49%
  • Disulfide 38%
  24 Citations (Scopus)

• Gene Targeting and Expression Modulation by Peptide Nucleic Acids (PNA)

  Nielsen, P. E., 2010, In: Current Pharmaceutical Design. 16, 28, p. 3118-23 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Peptide Nucleic Acids 100%
  • Peptide Nucleic Acid 85%
  • Gene Targeting 79%
  • Gene Expression 40%
  • Targeted Gene Repair 31%
  53 Citations (Scopus)

• Gestational protein restriction in mice has pronounced effects on gene expression in newborn offspring's liver and skeletal muscle; protective effect of taurine

  Mortensen, O. H., Olsen, H. L., Frandsen, L., Nielsen, P. E., Nielsen, F. C., Grunnet, N., Quistorff, B., Mortensen, O. H., Olsen, H. L., Frandsen, L., Nielsen, P. E., Nielsen, F. C., Grunnet, N. & Quistorff, B., 1 Jan 2010, In: Pediatric Research. 67, 1, p. 47-53 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Taurine 100%
  • Skeletal Muscle 66%
  • Gene Expression 50%
  • Liver 43%
  • Proteins 30%
  39 Citations (Scopus)

• Introducing Artificial DNA: PNA & XNA

  Nielsen, P. E., 1 Jul 2010, In: Artificial DNA. 1, 1, p. 1

  Research output: Contribution to journal › Journal article › Research › peer-review

• Modulation of mdm2 pre-mRNA splicing by 9-aminoacridine-PNA (peptide nucleic acid) conjugates targeting intron-exon junctions

  Shiraishi, T., Eysturskard, J. & Nielsen, P. E., 30 Jun 2010, In: BMC Cancer. 10, 1, p. 342

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Aminacrine 100%
  • Peptide Nucleic Acids 86%
  • RNA Splice Sites 72%
  • RNA Precursors 65%
  • Introns 56%
  14 Citations (Scopus)

• Natural - synthetic - artificial!

  Nielsen, P. E., 1 Jul 2010, In: Artificial DNA. 1, 1, p. 58-59 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Artificial Cells 100%
  • Artificial Chromosomes 60%
  • Genome 24%
  3 Citations (Scopus)

• Nucleic Acid Backbone Structure Variations: Peptide Nucleic Acids

  Nielsen, P. E., 2010, In: Encyclopedia of Life Sciences.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Peptide Nucleic Acid 100%
  • Deoxyribonucleic Acid 93%
  • Nucleic Acid 66%
  • Complementary Rna 36%
  • Messenger RNA 26%

• Peptide nucleic acids (PNA) in chemical biology and drug discovery

  Nielsen, P. E., Apr 2010, In: Chemistry & Biodiversity. 7, 4, p. 786-804 18 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  168 Citations (Scopus)

• Plastic Trash goes Biohybrid"-Rapid and Selective Functionalization of Inert Plastic Surfaces with Biomolecules

  Schiller, S. M., Kambhampati, D., Stengel, G., Dolderer, J., Nielsen, P. E., Förch, R. & Knoll, W., 19 Jan 2010, In: Macromolecular Chemistry and Physics. 211, 2, p. 222-228 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Peptide Nucleic Acids 100%
  • Plasma polymerization 87%
  • Biochips 67%
  • Biomolecules 65%
  • nucleic acids 60%
  1 Citation (Scopus)

• PNA-mediated modulation and redirection of Her-2 pre-mRNA splicing: specific skipping of erbB-2 exon 19 coding for the ATP catalytic domain

  Pankratova, S., Nielsen, B. N., Shiraishi, T. & Nielsen, P. E., Jan 2010, In: International Journal of Oncology. 36, 1, p. 29-38 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Peptide Nucleic Acids 100%
  • RNA Precursors 76%
  • Catalytic Domain 60%
  • Exons 56%
  • Adenosine Triphosphate 52%
  11 Citations (Scopus)

• Sequence-selective targeting of duplex DNA by peptide nucleic acids

  Nielsen, P. E., Apr 2010, In: Current Opinion in Molecular Therapeutics. 12, 2, p. 184-91 7 p.

  Research output: Contribution to journal › Review

  • Peptide Nucleic Acids 100%
  • Peptide Nucleic Acid 85%
  • Targeted Gene Repair 84%
  • DNA 37%
  • Modification 37%
  42 Citations (Scopus)

• Targeted gene repair facilitated by peptide nucleic acids (PNA)

  Nielsen, P. E., 18 Oct 2010, In: ChemBioChem. 11, 15, p. 2073-6 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  26 Citations (Scopus)
• 2009

  Cellular Bioavailability of Peptide Nucleic Acids (PNAs) Conjugated to Cell Penetrating Peptides

  Shiraishi, T. & Nielsen, P. E., 2009, Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines. jorgensen, L. & Nielson, H. M. (eds.). Nov 2009 ed. Wiley, p. 305-338 34 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  7 Citations (Scopus)

• High-affinity triplex targeting of double stranded DNA using chemically modified peptide nucleic acid oligomers

  Hansen, M. E., Bentin, T. & Nielsen, P. E., 2009, In: Nucleic Acids Research.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Aminacrine 100%
  • pseudoisocytosine 99%
  • Peptide Nucleic Acids 86%
  • DNA 32%
  • Intercalating Agents 30%
  53 Citations (Scopus)

• Hydrogen bonding versus stacking stabilization by modified nucleobases incorporated in PNA. DNA duplexes

  Sen, A. & Nielsen, P. E., 2009, In: Biophysical Chemistry. 141, 1, p. 29-33 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Thymine 100%
  • Hydrogen Bonding 89%
  • Nucleobase 80%
  • 1,8-naphthyridin-2(1H)-one 60%
  • 2,6-diaminopurine 44%
  14 Citations (Scopus)

• Peptide Nucleic Acids and the Origin of Life

  Nielsen, P. E., 2009, In Origin of Life, Chemical Approach. Herdewijn, P. & Kisakürek, M. V. (eds.). Verlag Helvetica Chimica Acta, Zürich; WILEY-VCH

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

• Self-assembling, dynamic alphaPNAs

  Nielsen, P. E., 2009, In: Chemistry & Biology. 16, 7, p. 689-90 1 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Thioester 100%
  • Nucleobase 92%
  • Molecule 29%
  6 Citations (Scopus)

• Targeted correction of a thalassemia-associated beta-globin mutation induced by pseudo-complementary peptide nucleic acids

  Lonkar, P., Kim, K-H., Kuan, J. Y., Chin, J. Y., Rogers, F. A., Knauert, M. P., Kole, R., Nielsen, P. E. & Glazer, P. M., 2009, In: Nucleic Acids Research. 37, 11, p. 3635-44 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Peptide Nucleic Acids 100%
  • beta-Globins 84%
  • Thalassemia 81%
  • Mutation 37%
  • Genetic Recombination 32%
  35 Citations (Scopus)

• Uranyl photofootprinting

  Nielsen, P. E., 2009, In: Methods in molecular biology (Clifton, N.J.). 543, p. 87-96 10 p.

  Research output: Contribution to journal › Journal article › Research

  • Nucleic Acids 100%
  • Phosphates 65%
  • UO(2) (VI) complex 65%
  • Cations 51%
  • DNA 42%
  5 Citations (Scopus)

• Uranyl Photofootprinting

  Nielsen, P. E., 2009, DNA-Protein Interactions: Principles and Protocols: Methods in Molecular Biology. Moss, T. & Leblanc, B. (eds.). mar-09 ed. Quebec City, Canada: Humana Press, Vol. 148. p. 111-119 9 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
• 2008

  A new molecule of life?

  Nielsen, P. E., 2008, In: Scientific American. 299, 6, p. 64-71 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  12 Citations (Scopus)

• Assembly of a Minimal Protocell

  Rasmussen, S., Bailey, J., Boncella, J., Chen, L., Collis, G., Colgate, S., DeClue, M., Fellermann, H., Goranovic, G., Jiang, Y., Knutson, C., Monnard, P-A., Mouffouk, F., Nielsen, P. E., Sen, A., Shreve, A., Tamulis, A., Travis, B., Weronski, P., Woodruff, W. H., & 10 othersZhang, J., Zhou, X., Ziock, H., Rasmussen, S., Bedau, M. A., Chen, L., Deamer, D., Krakauer, D. C., Packard, N. H. & Stadler, P. F., 2008, Protocells, Bridging Nonliving and Living Matter. MIT Press, Vol. 6. p. 125-155 30 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

• Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids.

  Chin, J. Y., Kuan, J. Y., Lonkar, P. S., Krause, D. S., Seidman, M. M., Peterson, K. R., Nielsen, P. E., Kole, R. & Glazer, P. M., 2008, In: Proceedings of the National Academy of Science of the United States of America. 105, 36, p. 13514-9 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Peptide Nucleic Acids 100%
  • beta-Globins 84%
  • Mutation 37%
  • Genetic Recombination 32%
  • Genes 27%
  62 Citations (Scopus)

• Dissecting direct and indirect readout of cAMP receptor protein DNA binding using an inosine and 2,6-diaminopurine in vitro selection system.

  Lindemose, S., Nielsen, P. E. & Møllegaard, N. E., 2008, In: Nucleic Acids Research. 36, 14, p. 4797-807 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 2,6-diaminopurine 100%
  • Cyclic AMP Receptor Protein 84%
  • Inosine 74%
  • Consensus Sequence 63%
  • Protein Binding 55%
  7 Citations (Scopus)

• Gene expression profiling of liver and skeletal muscle in newborn mice exposed to an in utero low protein diet with or without taurine

  Olsen, H. L., Mortensen, O. H., Nielsen, P. E., Nielsen, F. C., Grunnet, N. & Quistorff, B., 2008, In: Biochimica et Biophysica Acta - Bioenergetics. 1777, Suppl. S

  Research output: Contribution to journal › Journal article › Research › peer-review

• Improved cellular activity of antisense peptide nucleic acids by conjugation to a cationic peptide-lipid (CatLip) domain.

  Koppelhus, U., Shiraishi, T., Zachar, V., Pankratova, S. & Nielsen, P. E., 2008, In: Bioconjugate Chemistry. 19, 8, p. 1526-34 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Peptide Nucleic Acids 100%
  • Lipids 61%
  • Peptides 60%
  • Peptide Nucleic Acid 58%
  • Protein Domains 46%
  79 Citations (Scopus)

• Investigation of the charge effect on the electrochemical transduction in a quinone-based DNA sensor

  Reisberg, S., Piro, B., Noel, V., Nguyen, T. D., Nielsen, P. E. & Pham, M. C., 2008, In: Electrochimica Acta. 54, 2, p. 346-351 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Quinone 100%
  • Peptide Nucleic Acid 69%
  • Peptide Nucleic Acids 59%
  • DNA 56%
  • Electrostatics 29%
  20 Citations (Scopus)

• Label-free DNA electrochemical sensor based on a PNA-functionalized conductive polymer.

  Reisberg, S., Dang, L. A., Nguyen, Q. A., Piro, B., Noel, V., Nielsen, P. E., Le, L. A. & Pham, M. C., 2008, In: Talanta: The International Journal of Pure and Applied Analytical Chemistry. 76, 1, p. 206-10 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Peptide Nucleic Acid 100%
  • Nucleic Acid Probe 74%
  • Peptide 45%
  • Square Wave Voltammetry 30%
  • Quinone 25%
  50 Citations (Scopus)

• Modulating gene function with peptide nucleic acids (PNA)

  Nielsen, P. E. & Crooke, S. T., 2008, Antisense Drug Technology. 2nd ed. Taylor & Francis, Vol. 18. p. 507-518 11 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

• Peptide Nucleic Acids as Prebiotic and Abiotic Genetic Material

  Nielsen, P. E., Rasmussen, S., Bedau, M. A., Chen, L., Deamer, D., Krakauer, D. C., Packard, N. H. & Stadler, P. F., 2008, Protocells, Bridging Nonliving and Living Matter. MIT Press, Vol. 15. p. 337-346 9 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

• Phosphate Selective Uranyl Photo-Affinity Cleavage of Proteins. Determination of Phosphorylation Sites.

  Kristensen, L. H., Nielsen, P. E., Jørgensen, C. I., Kragelund, B. B. & Møllegaard, N. E., 2008, In: ChemBioChem. 9, 15, p. 2377-81 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  9 Citations (Scopus)

• PNA Directed Sequence Addressed Self-Assembly of DNA Nanostructures

  Nielsen, P. E., 2008, In: AIP Conference Proceedings. 1062, DNA-Based Nanodevices, p. 13-18 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  1 Citation (Scopus)

• Segmentation of rodent whole-body dynamic PET images: an unsupervised method based on voxel dynamics.

  Maroy, R., Boisgard, R., Comtat, C., Frouin, V., Cathier, P., Duchesnay, E., Dollé, F., Nielsen, P. E., Trébossen, R. & Tavitian, B., 2008, In: IEEE Transactions on Medical Imaging. 27, 3, p. 342-54 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Pharmacokinetics 100%
  • Positron emission tomography 97%
  • Positron-Emission Tomography 65%
  • Rodentia 58%
  • Drug Development 49%
  57 Citations (Scopus)

• Subnanomolar antisense activity of phosphonate-peptide nucleic acid (PNA) conjugates delivered by cationic lipids to HeLa cells.

  Shiraishi, T., Hamzavi, R. & Nielsen, P. E., 2008, In: Nucleic Acids Research. 36, 13, p. 4424-32 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Organophosphonates 100%
  • Peptide Nucleic Acids 99%
  • HeLa Cells 66%
  • Lipids 43%
  • Lipofectamine 9%
  63 Citations (Scopus)
• 2007

  Cellular antisense activity of peptide nucleic acid (PNAs) targeted to HIV-1 polypurine tract (PPT) containing RNA

  Boutimah-Hamoudi, F., Leforestier, E., Senamaud-Beaufort, C., Nielsen, P. E., Giovannangeli, C. & Saison-Behmoaras, T. E., 2007, In: Nucleic Acids Research. 35, 12, p. 3907-3917 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  13 Citations (Scopus)

• Corrigendum: Structural diversity of target-specific homopyrimidine peptide nucleic acid-dsDNA complexes.

  Bentin, T., Hansen, G. I. & Nielsen, P. E., 2007, In: Nucleic Acids Research. 35, 2, p. 702 1 p.

  Research output: Contribution to journal › Comment/debate › Research

  • Peptide Nucleic Acids 100%

• Efficient sequence-directed psoralen targeting using pseudocomplementary peptide nucleic acids

  Kim, K. H., Fan, X. J. & Nielsen, P. E., 2007, In: Bioconjugate Chemistry. 18, 2, p. 567-572 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  15 Citations (Scopus)

• Efficient sequence-directed psoralen targeting using pseudocomplementary Peptide nucleic acids

  Kim, K-H., Fan, X-J. & Nielsen, P. E., 30 Jan 2007, In: Bioconjugate Chemistry. 18, 2, p. 567-72 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Peptide Nucleic Acids 100%
  • Oligomers 66%
  • Psoralen 65%
  • Ficusin 64%
  • Peptide Nucleic Acid 58%

• Emergence of protocellular growth laws

  Rocheleau, T., Rasmussen, S., Nielsen, P. E., Jacobi, M. N. & Ziock, H., 2007, In: Philosophical Transactions of the Royal Society of London. Biological Sciences. 362, 1486, p. 1841-1845 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  19 Citations (Scopus)

• On the stability of peptide nucleic acid duplexes in the presence of organic solvents

  Sen, A. & Nielsen, P. E., 2007, In: Nucleic Acids Research. 35, 10, p. 3367-3374 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  32 Citations (Scopus)

• Peptide nucleic acids and the origin and homochirality of life

  Nielsen, P. E., 2007, In: Origin of Life Evolution of the Biosphere. 37, 4-5, p. 323-328 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  15 Citations (Scopus)

• Peptide nucleic acids and the origin of life

  Nielsen, P. E., 2007, In: Chemistry & Biodiversity. 4, 9, p. 1996-2002 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  51 Citations (Scopus)

• Peptide nucleic acids and the origin of life

  Nielsen, P. E., Sept 2007, In: Chemistry & Biodiversity. 4, 9, p. 1996-2002 7 p.

  Research output: Contribution to journal › Review

  • Peptide Nucleic Acids 100%
  • Origin of Life 75%
  • Prebiotics 59%
  • Peptide Nucleic Acid 58%
  • Peptides 30%

• Question 1: Peptide nucleic acids and the origin and homochirality of life

  Nielsen, P. E., Oct 2007, In: Origins of Life and Evolution of Biospheres. 37, 4-5, p. 323-8 6 p.

  Research output: Contribution to journal › Journal article › Research

  • genetic material 100%
  • nucleic acids 92%
  • nucleic acid 85%
  • peptides 77%
  • RNA 72%

• Site-directed gene mutation at mixed sequence targets by psoralen-conjugated pseudo-complementary peptide nucleic acids

  Kim, K. H., Nielsen, P. E. & Glazer, P. M., 2007, In: Nucleic Acids Research. 35, 22, p. 7604-7613 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  28 Citations (Scopus)
• 2006

  Cellular delivery of polyheteroaromate-peptide nucleic acid conjugates mediated by cationic lipids

  Shiraishi, T., Bendifallah, N. & Nielsen, P. E., 2006, In: Bioconjugate Chemistry. 17, 1, p. 189-194 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  27 Citations (Scopus)

• Cellular delivery of polyheteroaromate-peptide nucleic acid conjugates mediated by cationic lipids

  Shiraishi, T., Bendifallah, N. & Nielsen, P. E., 19 Jan 2006, In: Bioconjugate Chemistry. 17, 1, p. 189-94 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Peptide Nucleic Acids 100%
  • Liposomes 75%
  • 9-Aminoacridine 68%
  • Lipids 61%
  • Aminacrine 59%

• Cyclobutyl-carbonyl substituted PNA: synthesis and study of a novel PNA derivative

  Aguado, G. P., Rua, F., Branchadell, V., Nielsen, P. E. & Ortuno, R. M., 2006, In: Tetrahedron: Asymmetry. 17, 17, p. 2499-2503 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  7 Citations (Scopus)

• DNA gene targeting using peptide nucleic acid (PNA)

  Nielsen, P. E. & Waring, M. J., 2006, Sequence-specific DNA binding agents. Royal Society of Chemistry, Vol. 5. p. 96-108 12 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research