Lene Juel Rasmussen

Research output

Research output per year 1994 2009 2012 2013 2014 2015 2016 2017 2019 2019

• 78 Journal article
• 8 Review
• 1 Encyclopedia chapter
• 1 Conference article
• 1 More
  • 1 Net publication - Internet publication

Research output per year

Research output per year

Search results

• 2013

  Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells

  Machado, A. M. D., Desler, C., Boggild, S., Strickertsson, J. A. B., Friis-Hansen, L., Figueiredo, C., Seruca, R. & Rasmussen, L. J., Oct 2013, In: Mechanisms of Ageing and Development. 134, 10, p. 460-466 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Helicobacter Infections 100%
  • Mitochondrial DNA 98%
  • Helicobacter pylori 90%
  • DNA Repair 86%
  • Stomach 67%
  32 Citations (Scopus)

• Natural selection of mitochondria during somatic lifetime promotes healthy aging

  Rodell, A., Rasmussen, L. J., Bergersen, L. H., Singh, K. K. & Gjedde, A., 2013, In: Frontiers in Neuroenergetics. 5, p. 1-6 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Genetic Selection 100%
  • Healthy Aging 96%
  • Organelle Biogenesis 65%
  • Mitochondria 63%
  • Drive 53%
  13 Citations (Scopus)

• Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells

  Maynard, S., Keijzers, G., Gram, M., Madsen, C. D., Bendix, L., Budtz-Jørgensen, E., Molbo, D., Croteau, D. L., Osler, M., Stevnsner, T. V., Rasmussen, L. J., Dela, F., Avlund, K. & Bohr, V. A., 30 Nov 2013, In: Aging. p. 850-864 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Blood Cells 100%
  • Reactive Oxygen Species 97%
  • Respiration 67%
  • 2'-deoxycytidine 5'-triphosphate 61%
  • Deoxyribonucleotides 61%
  27 Citations (Scopus)

• Response to: Design of a core classification process for DNA mismatch repair variations of a priori unknown functional significance

  Rasmussen, L. J., Heinen, C. D., Royer-Pokora, B., Drost, M., Tavtigian, S., Hofstra, R. M. W. & de Wind, N., Jun 2013, In: Human Mutation. 34, 6, p. 923-4 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  1 Citation (Scopus)
• 2012

  14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif

  Andersen, S. D., Keijzers, G., Rampakakis, E., Engels, K., Luhn, P., El-Shemerly, M., Nielsen, F. C., Du, Y., May, A., Bohr, V. A., Ferrari, S., Zannis-Hadjopoulos, M., Fu, H. & Rasmussen, L. J., 1 Mar 2012, In: D N A Repair. 11, 3, p. 267-77 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • human EXO1 protein 100%
  • DNA Repair 44%
  • Protein 19%
  • Apoptosis Inducer 19%
  • Proteins 17%
  26 Citations (Scopus)

• Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells

  Cheng, C., Edin, N. F. J., Lauritzen, K. H., Aspmodal, I., Christoffersen, S., Jian, L., Rasmussen, L. J., Pettersen, E. O., Xiaoqun, G. & Bergersen, L. H., Jun 2012, In: Cellular oncology (Dordrecht). 35, 3, p. 217-27 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Brain Neoplasms 100%
  • Hypoxia 84%
  • Breast Neoplasms 68%
  • Neoplasms 31%
  • Brain 21%
  19 Citations (Scopus)

• Analysis of the antimicrobial susceptibility of the ionizing radiation-resistant bacterium Deinococcus radiodurans: implications for bioremediation of radioactive waste

  Bouchami, O., Sghaier, H., Madsen, C. D., Lazim, H., Saidi, M., Rasmussen, L. J. & Ben Hassan, A., Jun 2012, In: Annals of Microbiology.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Radioactive Waste 100%
  • Deinococcus 94%
  • Environmental Biodegradation 87%
  • Ionizing Radiation 61%
  • Bacteria 40%
  3 Citations (Scopus)

• A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants

  Drost, M., Zonneveld, J. B. M., van Hees, S., Rasmussen, L. J., Hofstra, R. M. W. & de Wind, N., Mar 2012, In: Human Mutation. 33, 3, p. 488-94 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hereditary Nonpolyposis Colorectal Neoplasms 100%
  • DNA Mismatch Repair 90%
  • Virulence 33%
  • Germ-Line Mutation 21%
  • Endometrial Neoplasms 19%
  33 Citations (Scopus)

• Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays

  Heinen, C. D. & Juel Rasmussen, L., 23 Jul 2012, In: Hereditary Cancer in Clinical Practice. 10, 1, p. 9

  Research output: Contribution to journal › Journal article › Research › peer-review

  • DNA Mismatch Repair 100%
  • Hereditary Nonpolyposis Colorectal Neoplasms 55%
  • Genes 33%
  • Germ-Line Mutation 15%
  • Disease Susceptibility 15%
  23 Citations (Scopus)

• Functional characterization of MLH1 missense variants identified in Lynch Syndrome patients

  Andersen, S. D., Liberti, S. E., Lützen, A., Drost, M., Bernstein, I., Nilbert, M., Dominguez, M., Nyström, M., Hansen, T. V. O., Christoffersen, J. W., Jäger, A. C., de Wind, N., Nielsen, F. C., Tørring, P. M. & Rasmussen, L. J., Dec 2012, In: Human Mutation. 33, 12, p. 1647-1655 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hereditary Nonpolyposis Colorectal Neoplasms 100%
  • DNA Mismatch Repair 45%
  • Proteins 27%
  • exodeoxyribonuclease I 22%
  • Germ-Line Mutation 14%
  14 Citations (Scopus)

• Genome-wide screens for expressed hypothetical proteins

  Madsen, C. D., Durhuus, J. A. & Rasmussen, L. J., 2012, In: Methods in molecular biology (Clifton, N.J.). 815, p. 25-38 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Genome 100%
  • Pseudogenes 94%
  • Proteome 76%
  • Open Reading Frames 70%
  • Proteins 54%
  6 Citations (Scopus)

• Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?

  Hansen, T. L., Rasmussen, L. J., Madsen, C. D., Frederiksen, J. B., Espersen, M. L. M. & Singh, K. K., 2012, In: Journal of Aging Research. 2012, p. 192503 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Oxidative Phosphorylation 100%
  • Adenosine Triphosphate 69%
  • Pathology 28%
  • Myocardium 18%
  • Skeletal Muscle 17%
  114 Citations (Scopus)

  1500 Downloads (Pure)

• Mitochondria in biology and medicine

  Madsen, C. D. & Rasmussen, L. J., Jul 2012, In: Mitochondrion. 12, 4, p. 472-6 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mitochondrial cytopathy 100%
  • Congresses 58%
  • Mitochondria 49%
  • Medicine 43%
  • India 34%
  7 Citations (Scopus)

• Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages

  Jantzen, K., Roursgaard, M., Madsen, C. D., Loft, S., Rasmussen, L. J. & Møller, P., Nov 2012, In: Mutagenesis. 27, 6, p. 693-701 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Vehicle Emissions 100%
  • Coculture Techniques 71%
  • DNA Damage 62%
  • Epithelial Cells 51%
  • Macrophages 50%
  53 Citations (Scopus)

• Pathological assessment of mismatch repair gene variants in Lynch syndrome: Past, present, and future

  Rasmussen, L. J., Heinen, C. D., Royer-Pokora, B., Drost, M., Tavtigian, S., Hofstra, R. M. W. & de Wind, N., Dec 2012, In: Human Mutation. 33, 12, p. 1617-25 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hereditary Nonpolyposis Colorectal Neoplasms 100%
  • DNA Mismatch Repair 90%
  • Virulence 33%
  • Genes 30%
  • Hereditary Neoplastic Syndromes 28%
  54 Citations (Scopus)

• The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients

  Jensen, M. B., Dunn, C. A., Keijzers, G., Kulikowicz, T., Rasmussen, L. J., Croteau, D. L. & Bohr, V. A., Nov 2012, In: Aging. 4, 11, p. 790-802 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Adenosine Triphosphatases 100%
  • Mutant Proteins 71%
  • Mutation 55%
  • DNA 55%
  • RecQ Helicases 51%
  8 Citations (Scopus)
• 2011

  Aging, longevity and health

  Rasmussen, L. J., Sander, M., Wewer, U. M. & Bohr, V. A., Oct 2011, In: Mechanisms of Ageing and Development. p. 522-32 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Healthy Aging 100%
  • Longevity 71%
  • Neurosciences 42%
  • Denmark 42%
  • Health 38%
  2 Citations (Scopus)

• Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks

  Liberti, S. E., Andersen, S. D., Wang, J., May, A., Miron, S., Perderiset, M., Keijzers, G., Nielsen, F. C., Charbonnier, J-B., Bohr, V. A. & Rasmussen, L. J., 2 Jan 2011, In: DNA Repair. 10, 1, p. 73-86 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • human EXO1 protein 100%
  • DNA Mismatch Repair 56%
  • Double-Stranded DNA Breaks 54%
  • Proliferating Cell Nuclear Antigen 22%
  • Protein 19%
  32 Citations (Scopus)

• The importance of mitochondrial DNA in aging and cancer

  Madsen, C. D., Espersen, M. L. M., Singh, K. K. & Rasmussen, L. J., 30 Mar 2011, In: Journal of Aging Research. 2011, p. 407536

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mitochondrial DNA 100%
  • Mitochondrial Genome 79%
  • Deoxyribonucleotides 48%
  • Ribonucleotides 45%
  • Premature Aging 42%
  35 Citations (Scopus)
• 2010

  Helicobacter pylori infection generates genetic instability in gastric cells

  Machado, A. M. D., Figueiredo, C., Seruca, R. & Rasmussen, L. J., Aug 2010, In: BBA General Subjects. 1806, 1, p. 58-65 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Helicobacter Infections 100%
  • Helicobacter pylori 90%
  • Mutation 79%
  • Stomach 67%
  • Mitochondrial DNA 42%
  63 Citations (Scopus)

• The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism

  Madsen, C. D., Lykke, A. & Rasmussen, L. J., 1 Jan 2010, In: Journal of Nucleic Acids. 2010

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Deoxyribonucleotides 100%
  • Metabolic Networks and Pathways 99%
  • Ribonucleotides 95%
  • Deoxyribonucleotide 93%
  • Ribonucleotide 81%
  38 Citations (Scopus)

• Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage

  Skovgaard, T., Rasmussen, L. J. & Munch-Petersen, B., Jun 2010, In: Nucleosides, Nucleotides and Nucleic Acids. 29, 4-6, p. 347-51 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • thymidine kinase 1 100%
  • thymidine 5'-triphosphate 90%
  • Thymidine 66%
  • DNA Damage 52%
  • DNA Repair-Deficiency Disorders 29%
  1 Citation (Scopus)
• 2009

  Biochemical characterization of MLH3 missense mutations does not reveal an apparent role of MLH3 in Lynch syndrome

  Ou, J., Rasmussen, M., Westers, H., Andersen, S. D., Jager, P. O., Kooi, K. A., Niessen, R. C., Eggen, B. J. L., Nielsen, F. C., Kleibeuker, J. H., Sijmons, R. H., Rasmussen, L. J. & Hofstra, R. M. W., 2009, In: Genes, Chromosomes & Cancer. 48, 4, p. 340-50 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hereditary Nonpolyposis Colorectal Neoplasms 100%
  • Missense Mutation 78%
  • Colorectal Neoplasms 40%
  • Protein Stability 29%
  • Germ-Line Mutation 28%
  14 Citations (Scopus)

• Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair

  Dherin, C., Gueneau, E., Francin, M., Nunez, M., Miron, S., Liberti, S. E., Rasmussen, L. J., Zinn-Justin, S., Gilquin, B., Charbonnier, J-B. & Boiteux, S., 2009, In: Molecular and Cellular Biology. 29, 3, p. 907-18 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • MutL Proteins 100%
  • exodeoxyribonuclease I 98%
  • DNA Mismatch Repair 67%
  • Yeasts 45%
  • Binding Sites 43%
  44 Citations (Scopus)

• Differential expression of hMLH1 in sporadic human colorectal cancer tumors and distant metastases

  Larsen, N. B., Heiberg Engel, P. J., Rasmussen, M. & Rasmussen, L. J., 2009, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 11, p. 839-48 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Colorectal Neoplasms 100%
  • Neoplasm Metastasis 77%
  • DNA Mismatch Repair 49%
  • Neoplasms 40%
  • Lymph Nodes 29%
  3 Citations (Scopus)

• Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells

  Machado, A. M. D., Figueiredo, C., Touati, E., Máximo, V., Sousa, S., Michel, V., Carneiro, F., Nielsen, F. C., Seruca, R. & Rasmussen, L. J., 2009, In: Clinical Cancer Research. 15, 9, p. 2995-3002 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Helicobacter Infections 100%
  • Mitochondrial DNA 98%
  • Helicobacter pylori 90%
  • Stomach 67%
  • DNA Mismatch Repair 41%
  106 Citations (Scopus)

• In Silico screening for functional candidates amongst hypothetical proteins

  Desler, C., Suravajhala, P., Sanderhoff, M., Rasmussen, M. & Rasmussen, L. J., 2009, In: BMC Bioinformatics. 10, p. 289

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Screening 100%
  • Protein 94%
  • Computer Simulation 85%
  • Proteins 82%
  • Strategy 24%
  28 Citations (Scopus)

• Novel DNA mismatch-repair activity involving YB-1 in human mitochondria

  de Souza-Pinto, N. C., Mason, P. A., Hashiguchi, K., Weissman, L., Tian, J., Guay, D., Lebel, M., Stevnsner, T. V., Rasmussen, L. J. & Bohr, V. A., 2009, In: DNA Repair. 8, 6, p. 704-19 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • DNA Mismatch Repair 100%
  • Mitochondria 69%
  • Mutation 35%
  • Protein 34%
  • Mitochondrial DNA 29%
  123 Citations (Scopus)

• Nuclear translocation contributes to regulation of DNA excision repair activities

  Knudsen, N. Ø., Andersen, S. D., Lützen, A., Nielsen, F. C. & Rasmussen, L. J., 2009, In: DNA Repair. 8, 6, p. 682-9 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • DNA Repair 100%
  • Protein 44%
  • Cell Nucleus Active Transport 42%
  • Proteins 29%
  • DNA Mismatch Repair 21%
  38 Citations (Scopus)

• Repair of DNA damage induced by anthanthrene, a polycyclic aromatic hydrocarbon (PAH) without bay or fjord regions

  Madsen, C. D., Johannessen, C. & Rasmussen, L. J., 2009, In: Chemico-Biological Interactions. 177, 3, p. 212-7 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • anthanthrene 100%
  • Anthanthrene 77%
  • Estuaries 70%
  • Bays 56%
  • Polycyclic Aromatic Hydrocarbons 55%
  11 Citations (Scopus)
• 2008

  Functional analysis of HNPCC-related missense mutations in MSH2

  Lützen, A., de Wind, N., Georgijevic, D., Nielsen, F. C. & Rasmussen, L. J., 14 Oct 2008, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 645, 1-2, p. 44-55 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hereditary Nonpolyposis Colorectal Neoplasms 100%
  • Missense Mutation 78%
  • Mutation 64%
  • DNA Mismatch Repair 54%
  • Mutant Proteins 48%
  34 Citations (Scopus)
• 2007

  Mitochondria as determinant of nucleotide pools and chromosomal stability

  Desler, C., Munch-Petersen, B., Stevnsner, T., Matsui, S-I., Kulawiec, M., Singh, K. K. & Rasmussen, L. J., 1 Dec 2007, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 625, 1-2, p. 112-24 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Deoxyribonucleosides 100%
  • Chromosomal Instability 80%
  • triphosphoric acid 76%
  • Deoxyribonucleoside 67%
  • Mitochondria 53%
  63 Citations (Scopus)

• Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1)

  Knudsen, N. Ø., Nielsen, F. C., Vinther, L., Bertelsen, R., Holten-Andersen, S., Liberti, S. E., Hofstra, R., Kooi, K. & Rasmussen, L. J., 2007, In: Nucleic Acids Research. 35, 8, p. 2609-19 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • human EXO1 protein 100%
  • MutS Homolog 3 Protein 99%
  • exodeoxyribonuclease I 82%
  • DNA Mismatch Repair 56%
  • Nuclear Localization Signals 30%
  30 Citations (Scopus)
• 2006

  The role of mitochondrial dNTP levels in cells with reduced TK2 activity

  Desler, C., Munch-Petersen, B. & Rasmussen, L. J., 2006, In: Nucleosides, nucleotides & nucleic acids. 25, 9-11, p. 1171-5 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • thymidine kinase 2 100%
  • Thymidine 62%
  • Mitochondrial DNA 29%
  • Mitochondria 23%
  • 2'-deoxycytidine 5'-triphosphate 21%
  7 Citations (Scopus)
• 2004

  Cadmium inhibits human DNA mismatch repair in vivo

  Lützen, A., Liberti, S. E. & Rasmussen, L. J., 13 Aug 2004, In: Biochemical and Biophysical Research Communications. 321, 1, p. 21-5 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • DNA Mismatch Repair 100%
  • Cadmium 95%
  • Zinc 32%
  • Phosphodiesterase I 26%
  • Alkylation 22%
  64 Citations (Scopus)

• Is hEXO1 a cancer predisposing gene?

  Liberti, S. E. & Rasmussen, L. J., Aug 2004, In: Molecular Cancer Research. 2, 8, p. 427-32 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  37 Citations (Scopus)
• 2000

  The LipB protein is a negative regulator of dam gene expression in Escherichia coli

  Vaisvila, R., Rasmussen, L. J., Lobner-Olesen, A., von Freiesleben, U. & Marinus, M. G., 15 Nov 2000, In: B B A - Reviews on Cancer. 1494, 1-2, p. 43-53 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Regulator Genes 100%
  • Escherichia coli 67%
  • Gene Expression 57%
  • Growth 48%
  • His-His-His-His-His-His 45%
  10 Citations (Scopus)
• 1995

  Growth-rate-dependent transcription initiation from the dam P2 promoter

  Rasmussen, L. J., Løbner-Olesen, A. & Marinus, M. G., 19 May 1995, In: Gene. 157, 1-2, p. 213-5 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Growth 100%
  • Genetic Promoter Regions 63%
  • Escherichia coli 46%
  • Genes 26%
  17 Citations (Scopus)
• 1994

  Novel growth rate control of dam gene expression in Escherichia coli

  Rasmussen, L. J., Marinus, M. G. & Løbner-Olesen, A., May 1994, In: Molecular Microbiology. 12, 4, p. 631-8 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Escherichia coli 100%
  • Gene Expression 85%
  • Growth 71%
  • beta-Galactosidase 62%
  • rRNA Genes 59%
  19 Citations (Scopus)