Jiri Lukas

Research output

Research output per year 2000 2009 2012 2013 2019

• 52 Journal article
• 3 Review
• 1 Book chapter
• 1 Comment/debate
• 1 More
  • 1 Letter

Research output per year

Research output per year

Search results

• 2019

  53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage

  Spies, J., Lukas, C., Somyajit, K., Rask, M-B., Lukas, J. & Neelsen, K. J., 1 Apr 2019, In: Nature Cell Biology. 21, p. 487-497

  Research output: Contribution to journal › Journal article › Research › peer-review

  • DNA Damage 100%
  • DNA 64%
  • Genome 31%
  • Mutagens 27%
  • Interphase 26%
  26 Citations (Scopus)

• Stabilization of chromatin topology safeguards genome integrity

  Ochs, F., Karemore, G., Miron, E., Brown, J., Sedlackova, H., Rask, M-B., Lampe, M., Buckle, V., Schermelleh, L., Lukas, J. & Lukas, C., 24 Oct 2019, In: Nature. 574, 7779, p. 571-574 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chromatin 100%
  • Genome 76%
  • DNA 63%
  • DNA Repair 34%
  • cohesins 26%
  39 Citations (Scopus)
• 2018

  DNA damage-induced dynamic changes in abundance and cytosol-nuclear translocation of proteins involved in translational processes, metabolism, and autophagy

  Bennetzen, M. V., Kosar, M., Bunkenborg, J., Payne, M. R., Bartkova, J., Lindström, M. S., Lukas, J., Andersen, J. S., Bartek, J. & Larsen, D. H., 2 Sept 2018, In: Cell Cycle. 17, 17, p. 2146-2163

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Nuclear Proteins 100%
  • Cytosol 92%
  • Autophagy 92%
  • DNA Damage 83%
  • Ionizing Radiation 79%
  3 Citations (Scopus)

• DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

  Gupta, R., Somyajit, K., Narita, T., Maskey, E., Stanlie, A., Kremer, M., Typas, D., Lammers, M., Mailand, N., Nussenzweig, A., Lukas, J. & Choudhary, C., 3 May 2018, In: Cell. 173, 4, p. 972-988

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Poly(ADP-ribose) Polymerase Inhibitors 100%
  • DNA Repair 69%
  • Immunoglobulin Isotypes 66%
  • Genetic Recombination 36%
  • Vertebrates 33%
  144 Citations (Scopus)

• Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

  Galanos, P., Pappas, G., Polyzos, A., Kotsinas, A., Svolaki, I., Giakoumakis, N. N., Glytsou, C., Pateras, I. S., Swain, U., Souliotis, V. L., Georgakilas, A. G., Geacintov, N., Scorrano, L., Lukas, C., Lukas, J., Livneh, Z., Lygerou, Z., Chowdhury, D., Sørensen, C. S., Bartek, J., & 1 othersGorgoulis, V. G., 2018, In: Genome Biology (Online Edition). 19, p. 1-18 37.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • genetic instability 100%
  • Genomic Instability 80%
  • genomics 72%
  • repair 70%
  • annealing 31%
  28 Citations (Scopus)

  97 Downloads (Pure)
• 2017

  Redox-sensitive alteration of replisome architecture safeguards genome integrity

  Somyajit, K., Gupta, R., Sedlackova, H., Neelsen, K. J., Ochs, F., Rask, M-B., Choudhary, C. & Lukas, J., 10 Nov 2017, In: Science. 358, 6364, p. 797-802 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Peroxiredoxins 100%
  • Oxidation-Reduction 93%
  • Reactive Oxygen Species 78%
  • Ribonucleotide Reductases 67%
  • Genome 66%
  53 Citations (Scopus)

• Replication Catastrophe: When a Checkpoint Fails because of Exhaustion

  Toledo, L., Neelsen, K. J. & Lukas, J., 15 Jun 2017, In: Molecular Cell. 66, 6, p. 735-749 15 p.

  Research output: Contribution to journal › Review › peer-review

  • Genome 100%
  • DNA Replication 98%
  • Replication Origin 61%
  • Cell Death 37%
  • DNA 27%
  85 Citations (Scopus)
• 2016

  53BP1 fosters fidelity of homology-directed DNA repair

  Ochs, F., Somyajit, K., Altmeyer, M., Rask, M-B. D., Lukas, J. & Lukas, C., 1 Aug 2016, In: Nature Structural and Molecular Biology. 23, 8, p. 714-21 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • DNA Repair 100%
  • Chromatin 63%
  • Gene Conversion 48%
  • Double-Stranded DNA Breaks 41%
  • Genomic Instability 39%
  115 Citations (Scopus)

• Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks

  Sotiriou, S. K., Kamileri, I., Lugli, N., Evangelou, K., Da-Ré, C., Huber, F., Padayachy, L., Tardy, S., Nicati, N. L., Barriot, S., Ochs, F., Lukas, C., Lukas, J., Gorgoulis, V. G., Scapozza, L. & Halazonetis, T. D., 15 Dec 2016, In: Molecular Cell. 64, 6, p. 1127-1134 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • DNA Replication 100%
  • Oncogenes 37%
  • Rad52 DNA Repair and Recombination Protein 36%
  • Small Interfering RNA 33%
  • Neoplasms 25%
  129 Citations (Scopus)

• Profiling DNA damage response following mitotic perturbations

  Pedersen, R. S., Karemore, G., Gudjonsson, T., Rask, M-B., Neumann, B., Hériché, J-K., Pepperkok, R., Ellenberg, J., Gerlich, D. W., Lukas, J. & Lukas, C., 15 Dec 2016, In: Nature Communications. 7, 12 p., 13887.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • deoxyribonucleic acid 100%
  • DNA Damage 96%
  • Error 82%
  • damage 78%
  • perturbation 73%
  24 Citations (Scopus)

• TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity

  Moudry, P., Watanabe, K., Wolanin, K. M., Bartkova, J., Wassing, I. E., Watanabe, S., Strauss, R., Pedersen, R. T., Østergaard, V. H., Lisby, M., Andújar-Sánchez, M., Maya-Mendoza, A., Esashi, F., Lukas, J. & Bartek, J., 2016, In: The Journal of Cell Biology. 212, 3, p. 281-288 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Poly(ADP-ribose) Polymerase Inhibitors 100%
  • Type II DNA Topoisomerase 98%
  • Chromatin 66%
  • Carrier Proteins 64%
  • Phosphorylation 52%
  34 Citations (Scopus)

  160 Downloads (Pure)
• 2015

  A lncRNA to repair DNA

  Lukas, J. & Altmeyer, M., Nov 2015, In: E M B O Reports. 16, 11, p. 1413-4 2 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review

  • Long Noncoding RNA 100%
  • DNA Repair 85%
  • DNA Damage 60%
  • Biological Phenomena 22%
  • Maintenance 16%
  11 Citations (Scopus)

• Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining

  Zong, D., Callén, E., Pegoraro, G., Lukas, C., Lukas, J. & Nussenzweig, A., 1 Apr 2015, In: Nucleic Acids Research. 43, 10, p. 4950-61 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ectopic Gene Expression 100%
  • Genetic Recombination 87%
  • Homologous Recombination 68%
  • S Phase 59%
  • Tumor Suppressor p53-Binding Protein 1 53%
  17 Citations (Scopus)

• Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

  Altmeyer, M., Neelsen, K. J., Teloni, F., Pozdnyakova, I., Pellegrino, S., Grøfte, M., Rask, M-B. D., Streicher, W., Jungmichel, S., Nielsen, M. L. & Lukas, J., 19 Aug 2015, In: Nature Communications. 6, p. 1-12 8088.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • ribose 100%
  • Intrinsically Disordered Proteins 90%
  • Poly Adenosine Diphosphate Ribose 87%
  • Poly(ADPribose) 85%
  • adenosine diphosphate 84%
  230 Citations (Scopus)
• 2014

  The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage

  Larsen, D. H., Hari, F., Clapperton, J. A., Gwerder, M., Gutsche, K., Altmeyer, M., Jungmichel, S., Toledo Lazaro, L. I., Fink, D., Rask, M-B., Grøfte, M., Lukas, C., Nielsen, M. L., Smerdon, S. J., Lukas, J. & Stucki, M., Aug 2014, In: Nature Cell Biology. 16, 8, p. 792-803 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Nijmegen Breakage Syndrome 100%
  • Ribosomal RNA 79%
  • DNA Damage 54%
  • Chromosome Breakage 42%
  • Mandibulofacial Dysostosis 24%
  78 Citations (Scopus)
• 2013

  Acetylation dynamics of human nuclear proteins during the ionizing radiation-induced DNA damage response

  Bennetzen, M., Andersen, J. S., Lasen, D. H., Dinant, C., Watanabe, S., Bartek, J. & Lukas, J., 1 Jun 2013, In: Cell Cycle. 12, 11, p. 1688-1695 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acetylation 100%
  • Nuclear Proteins 98%
  • Ionizing Radiation 97%
  • DNA Damage 82%
  • Post Translational Protein Processing 32%
  25 Citations (Scopus)

• ATR-Chk1-APC/C-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress

  Yamada, M., Watanabe, K., Mistrik, M., Vesela, E., Protivankova, I., Mailand, N., Lee, M. H., Masai, H., Lukas, J. & Bartek, J., 15 Nov 2013, In: Genes & Development. 27, 22, p. 2459-2472 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Anaphase-Promoting Complex-Cyclosome 100%
  • Ubiquitin 68%
  • DNA Replication 68%
  • Phosphotransferases 52%
  • Ligases 49%
  50 Citations (Scopus)

• ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

  Toledo Lazaro, L. I., Altmeyer, M., Rask, M-B., Lukas, C., Larsen, D. H., Povlsen, L. K., Bekker-Jensen, S., Mailand, N., Bartek, J. & Lukas, J., 21 Nov 2013, In: Cell. 155, 5, p. 1088-1103 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Single-Stranded DNA 100%
  • Cell Nucleus 48%
  • Reduction 42%
  • DNA Damage 41%
  • Hypersensitivity 38%
  420 Citations (Scopus)

• Guarding against Collateral Damage during Chromatin Transactions

  Altmeyer, M. & Lukas, J., 20 Jun 2013, In: Cell. 153, 7, p. 1431-4 4 p.

  Research output: Contribution to journal › Review › peer-review

  • Chromatin 100%
  11 Citations (Scopus)

• JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks

  Watanabe, S., Watanabe, K., Akimov, V., Bartkova, J., Blagoev, B., Lukas, J. & Bartek, J., Dec 2013, In: Nature Structural and Molecular Biology. 20, p. 1425-1433

  Research output: Contribution to journal › Journal article › Research › peer-review

  • DNA Breaks 100%
  • Ubiquitination 88%
  • Chromatin 71%
  • DNA Damage 47%
  • Poly(ADP-ribose) Polymerase Inhibitors 35%
  65 Citations (Scopus)

• Molecular biology. Shielding broken DNA for a quick fix

  Lukas, J. & Lukas, C., 8 Feb 2013, In: Science (New York, N.Y.). 339, 6120, p. 652-3 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  10 Citations (Scopus)

• Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses

  Jungmichel, S., Rosenthal, F., Altmeyer, M., Lukas, J., Hottiger, M. O. & Nielsen, M. L., 24 Oct 2013, In: Molecular Cell. 52, 2, p. 272-285 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Poly ADP Ribosylation 100%
  • Proteome 68%
  • Adenosine Diphosphate 65%
  • DNA Damage 57%
  • Proteins 13%
  191 Citations (Scopus)

• Shielding broken DNA for a quick fix

  Lukas, J. & Lukas, C., 8 Feb 2013, In: Science. 339, 6120, p. 652-653 2 p.

  Research output: Contribution to journal › Review › peer-review

  • DNA Repair 100%
  • DNA 60%
  • Proteins 39%
  10 Citations (Scopus)

• The Chromatin Scaffold Protein SAFB1 Renders Chromatin Permissive for DNA Damage Signaling

  Altmeyer, M., Toledo Lazaro, L. I., Gudjonsson, T., Grøfte, M., Rask, M-B., Lukas, C., Akimov, V., Blagoev, B., Bartek, J. & Lukas, J., 24 Oct 2013, In: Molecular Cell. 52, 2, p. 206-220

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chromatin 100%
  • DNA Damage 98%
  • Cell Cycle Checkpoints 44%
  • Proteins 41%
  • Poly Adenosine Diphosphate Ribose 31%
  46 Citations (Scopus)

• The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis

  Evangelou, K., Bartkova, J., Kotsinas, A., Pateras, I. S., Liontos, M., Velimezi, G., Kosar, M., Liloglou, T., Trougakos, I. P., Dyrskjot, L., Andersen, C. L., Papaioannou, M., Drosos, Y., Papafotiou, G., Hodny, Z., Sosa-Pineda, B., Wu, X-R., Klinakis, A., Ørntoft, T. F., Lukas, J., & 2 othersBartek, J. & Gorgoulis, V. G., 1 Nov 2013, In: Cell Death and Differentiation. 20, 11, p. 1485-1497 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Reading Frames 100%
  • DNA Damage 66%
  • Carcinogenesis 58%
  • Urinary Bladder 20%
  • Cyclin-Dependent Kinase Inhibitor p16 18%
  46 Citations (Scopus)

• To spread or not to spread - chromatin modifications in response to DNA damage

  Altmeyer, M. & Lukas, J., Apr 2013, In: Current Opinion in Genetics & Development. 23, 2, p. 156-165 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chromatin 100%
  • DNA Damage 98%
  • Genome 19%
  • DNA 15%
  • Proteins 10%
  34 Citations (Scopus)
• 2012

  Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth

  Hamerlik, P., Lathia, J. D., Rasmussen, R., Wu, Q., Bartkova, J., Lee, M., Moudry, P., Bartek, J., Fischer, W., Lukas, J., Rich, J. N. & Bartek, J., 12 Mar 2012, In: The Journal of Experimental Medicine. 209, 3, p. 507-20 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Neuropilin-1 100%
  • Vascular Endothelial Growth Factor Receptor-2 83%
  • Vascular Endothelial Growth Factor Receptor 81%
  • Glioma 62%
  • Cell Survival 51%
  269 Citations (Scopus)

• CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination

  Falck, J., Forment, J. V., Coates, J., Mistrik, M., Lukas, J., Bartek, J. & Jackson, S. P., Jun 2012, In: E M B O Reports. 13, 6, p. 561-8 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cyclin-Dependent Kinases 100%
  • Homologous Recombination 96%
  • Recombinational DNA Repair 82%
  • Phosphorylation 58%
  • DNA 47%
  68 Citations (Scopus)

• DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

  Mosbech, A., Gibbs-Seymour, I., Kagias, K., Thorslund, T., Beli, P., Povlsen, L., Nielsen, S. V., Smedegaard, S., Sedgwick, G., Lukas, C., Hartmann-Petersen, R., Lukas, J., Choudhary, C. R., Pocock, R. D. J., Bekker-Jensen, S. & Mailand, N., Nov 2012, In: Nature Structural and Molecular Biology. 19, 11, p. 1084-92 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ubiquitin 100%
  • DNA Damage 86%
  • Proliferating Cell Nuclear Antigen 80%
  • Anaphase-Promoting Complex-Cyclosome 36%
  • DNA-Directed DNA Polymerase 27%
  120 Citations (Scopus)

• Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment

  Oplustilova, L., Wolanin, K., Bartkova, J., Lukas, J., Bartek, J., Lau, A., O'Connor, M. J., Mistrik, M., Korinkova, G., Simkova, D., Bouchal, J. & Lenobel, R., 15 Oct 2012, In: Cell Cycle. 11, 20, p. 3837-3850 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ribose 100%
  • Poly(ADP-ribose) Polymerase Inhibitors 98%
  • Biomarkers 48%
  • Neoplasms 24%
  • Breast Neoplasms 17%
  112 Citations (Scopus)

• Jiri Lukas: Visualizing genome integrity maintenance. Interview by Caitlin Sedwick

  Lukas, J., 9 Jul 2012, In: Journal of Cell Biology. 198, 1, p. 4-5 2 p.

  Research output: Contribution to journal › Journal article › Communication

  1 Citation (Scopus)

• LEDGF (p75) promotes DNA-end resection and homologous recombination

  Daugaard, M., Baude, A., Fugger, K., Povlsen, L. K., Beck, H., Sørensen, C. S., Petersen, N. H. T., Sorensen, P. H. B., Lukas, C., Bartek, J., Lukas, J., Rohde, M. & Jaattela, M., Aug 2012, In: Nature Structural & Molecular Biology. 19, 8, p. 803-810 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • lens epithelium-derived growth factor 100%
  • Homologous Recombination 66%
  • Double-Stranded DNA Breaks 33%
  • DNA 32%
  • Chromatin 25%
  107 Citations (Scopus)

• TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

  Gudjónsson, T., Altmeyer, M. F., Savic, V., Toledo Lazaro, L. I., Dinant, C., Grøfte, M., Bartkova, J., Poulsen, M., Oka, Y., Bekker-Jensen, S., Mailand, N., Neumann, B., Heriche, J-K., Shearer, R., Saunders, D., Bartek, J., Lukas, J. & Lukas, C., 17 Aug 2012, In: Cell. 150, 4, p. 697-709 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ubiquitination 100%
  • Histone 98%
  • Spreading 97%
  • Chromatin 81%
  • Chromosomes 72%
  204 Citations (Scopus)

• Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage

  Moudry, P., Lukas, C., Macurek, L., Hanzlikova, H., Hodny, Z., Lukas, J. & Bartek, J., 15 Apr 2012, In: Cell Cycle. 11, 8, p. 1573-82 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ubiquitin-Activating Enzymes 100%
  • Ubiquitination 65%
  • Ionizing Radiation 62%
  • DNA Damage 52%
  • Ubiquitin 40%
  46 Citations (Scopus)
• 2011

  53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

  Lukas, C., Savic, V., Bekker-Jensen, S., Doil, C., Neumann, B., Pedersen, R. S., Grøfte, M., Chan, K. L., Hickson, I. D., Bartek, J. & Lukas, J., 1 Mar 2011, In: Nature Cell Biology. 13, 3, p. 243-53 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chromosomes 100%
  • Genome 85%
  • Chromatin 74%
  • DNA 70%
  • condensin complexes 67%
  426 Citations (Scopus)
• 2010

  HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

  Bekker-Jensen, S., Danielsen, J. M. R., Fugger, K., Gromova, I., Nerstedt, A., Bartek, J., Lukas, J. & Mailand, N., Jan 2010, In: Nature Cell Biology. 12, 1, p. 80-6; sup pp 1-12

  Research output: Contribution to journal › Letter › peer-review

  • Ubiquitin 100%
  • DNA Repair 92%
  • Chromosomes 78%
  • DNA Damage 49%
  • Ligases 31%
  208 Citations (Scopus)
• 2009

  DNA repair: New tales of an old tail

  Lukas, J. & Bartek, J., 2009, In: Nature. 458, 7238, p. 581-3 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  19 Citations (Scopus)

• Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities

  Fugger, K., Mistrik, M., Danielsen, J. R., Dinant, C., Falck, J., Bartek, J., Lukas, J. & Mailand, N., 2009, In: Journal of Cell Biology. 186, 5, p. 655-63 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Recombinases 100%
  • Homologous Recombination 69%
  • Maintenance 52%
  • Genome 50%
  • Single-Stranded DNA 45%
  70 Citations (Scopus)

• Low-dose DNA damage and replication stress responses quantified by optimized automated single-cell image analysis

  Mistrik, M., Oplustilova, L., Lukas, J. & Bartek, J., 2009, In: Cell Cycle. 8, 16, p. 2592-9 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Single-Cell Analysis 100%
  • DNA Replication 74%
  • DNA Damage 64%
  • Fluorescence 30%
  • Homologous Recombination 27%
  17 Citations (Scopus)

• Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection

  Carson, C. T., Orazio, N. I., Lee, D. V., Suh, J., Bekker-Jensen, S., Araujo, F. D., Lakdawala, S. S., Lilley, C. E., Bartek, J., Lukas, J. & Weitzman, M. D., 2009, In: EMBO Journal. 28, 6, p. 652-62 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Adenoviridae Infections 100%
  • Ataxia Telangiectasia 93%
  • Virus Diseases 54%
  • Immobilization 50%
  • DNA Damage 42%
  76 Citations (Scopus)

• Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

  Marteijn, J. A., Bekker-Jensen, S., Mailand, N., Lans, H., Schwertman, P., Gourdin, A. M., Dantuma, N. P., Lukas, J. & Vermeulen, W., 2009, In: Journal of Cell Biology. 186, 6, p. 835-47 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ubiquitination 100%
  • DNA Repair 85%
  • DNA Damage 80%
  • 1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione 22%
  • Ataxia Telangiectasia 19%
  143 Citations (Scopus)

• RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

  Doil, C., Mailand, N., Bekker-Jensen, S., Menard, P., Larsen, D. H., Pepperkok, R., Ellenberg, J., Panier, S., Durocher, D., Bartek, J., Lukas, J. & Lukas, C., 2009, In: Cell. 136, 3, p. 435-46 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ubiquitin 100%
  • Lysine 94%
  • Ubiquitination 80%
  • Chromosomes 78%
  • Chromatin 66%
  629 Citations (Scopus)

• USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin

  Faustrup, H., Bekker-Jensen, S., Bartek, J., Lukas, J. & Mailand, N., 2009, In: Journal of Cell Biology. 184, 1, p. 13-9 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ubiquitin-Specific Proteases 100%
  • beta-Transducin Repeat-Containing Proteins 67%
  • Proteolysis 62%
  • Anaphase-Promoting Complex-Cyclosome 39%
  • Ataxia Telangiectasia 33%
  83 Citations (Scopus)
• 2008

  HCLK2 is required for activity of the DNA damage response kinase ATR

  Rendtlew Danielsen, J. M., Larsen, D. H., Schou, K. B., Freire, R., Falck, J., Bartek, J. & Lukas, J., 2008, In: Journal of Biological Chemistry. 284, 7, p. 4140-7 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • DNA Damage 100%
  • Phosphotransferases 88%
  • Protein Kinases 52%
  • Protein 47%
  • Cell Survival 43%
  34 Citations (Scopus)

• Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin

  Melander, F., Bekker-Jensen, S., Falck, J., Bartek, J., Mailand, N. & Lukas, J., 21 Apr 2008, In: Journal of Cell Biology. 181, 2, p. 213-26 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Casein Kinase II 100%
  • Chromatin 65%
  • DNA Damage 64%
  • Phosphorylation 51%
  • Nijmegen Breakage Syndrome 39%
  167 Citations (Scopus)
• 2007

  Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks

  Bekker-Jensen, S., Fugger, K., Danielsen, J. R., Gromova, I., Sehested, M., Celis, J., Bartek, J., Lukas, J. & Mailand, N., 6 Jul 2007, In: Journal of Biological Chemistry. 282, 27, p. 19638-43 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Clonogenic 100%
  • DNA Breaks 79%
  • Ionizing Radiation 79%
  • human APLF protein 78%
  • Genotoxic 77%
  65 Citations (Scopus)

• RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

  Mailand, N., Bekker-Jensen, S., Faustrup, H., Melander, F., Bartek, J., Lukas, C. & Lukas, J., 2007, In: Cell. 131, 5, p. 887-900 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Double-Stranded DNA Breaks 100%
  • Ubiquitination 94%
  • Histone 93%
  • Histones 81%
  • BRCA1 Protein 43%
  848 Citations (Scopus)
• 2006

  Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

  Liu, S., Bekker-Jensen, S., Mailand, N., Lukas, C., Bartek, J. & Lukas, J., 2006, In: Molecular and Cellular Biology. 26, 16, p. 6056-64 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • DNA Damage 100%
  • Phosphorylation 33%
  • RNA Interference 31%
  • Checkpoint Kinase 1 25%
  • Down-Regulation 11%
  129 Citations (Scopus)

• Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

  Mailand, N., Bekker-Jensen, S., Bartek, J. & Lukas, J., 2006, In: Molecular Cell. 23, 3, p. 307-18 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • beta-Transducin Repeat-Containing Proteins 100%
  • DNA Damage 51%
  • Mitosis 38%
  • Ligases 21%
  • Ubiquitination 21%
  194 Citations (Scopus)

• Immunoprecipitation of Proteins under Nondenaturing Conditions

  Lukas, J., Bartek, J. & Hansen, K., 1 Dec 2006, Cell Biology, Four-Volume Set. Elsevier Science Inc., Vol. 4. p. 253-258 6 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  • Protein 100%
  • Antigen 28%
  • Monolayer 25%
  • Mass Spectrometry 23%
  • Buffer Solution 22%
  1 Citation (Scopus)