TY - JOUR
T1 - Venous thromboembolism and risk of idiopathic interstitial pneumonia
T2 - a nationwide study
AU - Sode, Birgitte F
AU - Dahl, Morten
AU - Nielsen, Sune F
AU - Nordestgaard, Børge G
PY - 2010/5/15
Y1 - 2010/5/15
N2 - Rationale: Idiopathic interstitial pneumonia is characterized by pulmonary fibrosis and high mortality. Objectives: We examined the association between ever-diagnosed venous thromboembolism and risk of incident idiopathic interstitial pneumonia. Venous thromboembolism was taken as a proxy for a procoagulant state in an individual. Methods: We conducted a study of the entire Danish population from 1980 through 2007, comprising 7.4 million individuals. Incident idiopathic interstitial pneumonia, ever-diagnosed venous thromboembolism, and use of prescription anticoagulants were drawn from national Danish registries. Measurements and Main Results: Age-standardized incidence rates per 10,000 person-years for idiopathic interstitial pneumonia were higher amongthose ever diagnosed with venous thromboembolism (1.8; n = 158,676), pulmonary embolism (2.8; n = 70,586), and deep venous thrombosis only (1.2; n = 88,090), than among control subjects (0.8; n = 7,260,278). Multivariate-adjusted hazard ratios for idiopathic interstitial pneumonia were 1.8 (95% confidence interval [CI], 1.7-1.9) in those ever diagnosed with venous thromboembolism, 2.4 (95% CI, 2.3-2.6) in those ever diagnosed with pulmonary embolism, and 1.3 (95% CI, 1.2-1.4) in those ever diagnosed with deep venous thrombosis only, compared with control subjects. Corresponding hazard ratios in those ever diagnosed with venous thromboembolism stratified in those ever and never treated with anticoagulants were 1.4 (95%CI, 1.2-1.6) and 2.8 (95% CI, 2.4-3.1) (venous thromboembolism X anticoagulation use interaction on idiopathic interstitial pneumonia outcome: P = 1.5 × 10-10). Conclusions: In the general population, ever-diagnosed venous thromboembolism was associated with idiopathic interstitial pneumonia, particularly among those never treated with anticoagulants.
AB - Rationale: Idiopathic interstitial pneumonia is characterized by pulmonary fibrosis and high mortality. Objectives: We examined the association between ever-diagnosed venous thromboembolism and risk of incident idiopathic interstitial pneumonia. Venous thromboembolism was taken as a proxy for a procoagulant state in an individual. Methods: We conducted a study of the entire Danish population from 1980 through 2007, comprising 7.4 million individuals. Incident idiopathic interstitial pneumonia, ever-diagnosed venous thromboembolism, and use of prescription anticoagulants were drawn from national Danish registries. Measurements and Main Results: Age-standardized incidence rates per 10,000 person-years for idiopathic interstitial pneumonia were higher amongthose ever diagnosed with venous thromboembolism (1.8; n = 158,676), pulmonary embolism (2.8; n = 70,586), and deep venous thrombosis only (1.2; n = 88,090), than among control subjects (0.8; n = 7,260,278). Multivariate-adjusted hazard ratios for idiopathic interstitial pneumonia were 1.8 (95% confidence interval [CI], 1.7-1.9) in those ever diagnosed with venous thromboembolism, 2.4 (95% CI, 2.3-2.6) in those ever diagnosed with pulmonary embolism, and 1.3 (95% CI, 1.2-1.4) in those ever diagnosed with deep venous thrombosis only, compared with control subjects. Corresponding hazard ratios in those ever diagnosed with venous thromboembolism stratified in those ever and never treated with anticoagulants were 1.4 (95%CI, 1.2-1.6) and 2.8 (95% CI, 2.4-3.1) (venous thromboembolism X anticoagulation use interaction on idiopathic interstitial pneumonia outcome: P = 1.5 × 10-10). Conclusions: In the general population, ever-diagnosed venous thromboembolism was associated with idiopathic interstitial pneumonia, particularly among those never treated with anticoagulants.
KW - Adult
KW - Aged
KW - Anticoagulants
KW - Case-Control Studies
KW - Denmark
KW - Female
KW - Humans
KW - Idiopathic Interstitial Pneumonias
KW - Lung Diseases, Interstitial
KW - Male
KW - Middle Aged
KW - Population Surveillance
KW - Proportional Hazards Models
KW - Pulmonary Embolism
KW - Registries
KW - Risk Assessment
KW - Venous Thromboembolism
KW - Young Adult
U2 - 10.1164/rccm.200912-1951OC
DO - 10.1164/rccm.200912-1951OC
M3 - Journal article
C2 - 20167844
SN - 1073-449X
VL - 181
SP - 1085
EP - 1092
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
IS - 10
ER -