TY - JOUR
T1 - Use of non-prescription analgesics and male reproductive function
AU - Høyer, B. B.
AU - Ramlau-Hansen, C. H.
AU - Bonde, J. P.
AU - Larsen, S. B.
AU - Toft, G.
PY - 2017/12
Y1 - 2017/12
N2 - We studied the association between intake of non-prescription analgesics and semen quality and male reproductive hormone levels in a cross-sectional study among 1493 men. The men provided one semen (n = 1493) and blood sample (n = 1056) and filled in questionnaires on use of non-prescription analgesics (paracetamol, NSAIDs and combination drugs (yes/no)). Adjusting for age, study and other covariates, we observed no association between intake of non-prescription analgesics and markers of semen quality. Adjusting for age and time of day of blood sampling, users of non-prescription analgesics had a 10.4% (95% confidence interval (CI) 4.0–17.1%) higher testosterone level than non-users. When we stratified by medication type, the association between analgesics and higher testosterone was observed between users of non-steroidal anti-inflammatory drugs (NSAIDs) and combination drugs but not paracetamol. This study suggests that use of non-prescription analgesics is associated with slightly higher serum testosterone levels than non-use.
AB - We studied the association between intake of non-prescription analgesics and semen quality and male reproductive hormone levels in a cross-sectional study among 1493 men. The men provided one semen (n = 1493) and blood sample (n = 1056) and filled in questionnaires on use of non-prescription analgesics (paracetamol, NSAIDs and combination drugs (yes/no)). Adjusting for age, study and other covariates, we observed no association between intake of non-prescription analgesics and markers of semen quality. Adjusting for age and time of day of blood sampling, users of non-prescription analgesics had a 10.4% (95% confidence interval (CI) 4.0–17.1%) higher testosterone level than non-users. When we stratified by medication type, the association between analgesics and higher testosterone was observed between users of non-steroidal anti-inflammatory drugs (NSAIDs) and combination drugs but not paracetamol. This study suggests that use of non-prescription analgesics is associated with slightly higher serum testosterone levels than non-use.
KW - Gonadal steroid hormones
KW - Non-steroidal anti-inflammatory drugs
KW - Paracetamol
KW - Reproductive health
KW - Semen analysis
UR - http://www.scopus.com/inward/record.url?scp=85029372256&partnerID=8YFLogxK
U2 - 10.1016/j.reprotox.2017.09.004
DO - 10.1016/j.reprotox.2017.09.004
M3 - Journal article
C2 - 28899770
AN - SCOPUS:85029372256
SN - 0890-6238
VL - 74
SP - 70
EP - 76
JO - Reproductive Toxicology
JF - Reproductive Toxicology
ER -