Use of NMR in profiling of cocaine seizures

Bruno Pagano; Ilaria Lauri; Stefano De Tito; Guido Persico; Maria Giovanna Chini; Anders Malmendal; Ettore Novellino; Antonio Randazzo

doi:10.1016/j.forsciint.2013.04.028

Use of NMR in profiling of cocaine seizures

Bruno Pagano, Ilaria Lauri, Stefano De Tito, Guido Persico, Maria Giovanna Chini, Anders Malmendal, Ettore Novellino, Antonio Randazzo

Inflammation, Metabolism and Oxidation

14 Citationer (Scopus)

Abstract

Cocaine is the most widely used illicit drug, and its origin is always the focus of intense investigation aimed at identifying the trafficking routes. Since NMR represents a unique methodology for performing chemical identification and quantification, here it is proposed a strategy based on (1)H NMR spectral analysis in conjunction with multivariate analysis to identify the chemical "fingerprint" of cocaine samples, and to link cocaine samples based on this information. The most relevant spectral regions containing the fingerprint have been identified: δH 0.86-0.96, 1.50-1.56, 5.90-5.93, 6.48-6.52, 7.31-7.34, 7.61-7.63, 7.68-7.72ppm. The strategy has been applied on samples seized in different times and places in Naples (Italy). The chemical "fingerprint" depend on what plant they were extracted from, where it was cultivated, and which procedures were used for extraction and purification, thus adding significant information in the process toward identification of the trafficking routes for this drug.

Originalsprog	Engelsk
Tidsskrift	Forensic Science International
Vol/bind	231
Udgave nummer	1-3
Sider (fra-til)	120-4
Antal sider	5
ISSN	0379-0738
DOI	https://doi.org/10.1016/j.forsciint.2013.04.028
Status	Udgivet - 10 sep. 2013

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10.1016/j.forsciint.2013.04.028

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title = "Use of NMR in profiling of cocaine seizures",

abstract = "Cocaine is the most widely used illicit drug, and its origin is always the focus of intense investigation aimed at identifying the trafficking routes. Since NMR represents a unique methodology for performing chemical identification and quantification, here it is proposed a strategy based on (1)H NMR spectral analysis in conjunction with multivariate analysis to identify the chemical {"}fingerprint{"} of cocaine samples, and to link cocaine samples based on this information. The most relevant spectral regions containing the fingerprint have been identified: δH 0.86-0.96, 1.50-1.56, 5.90-5.93, 6.48-6.52, 7.31-7.34, 7.61-7.63, 7.68-7.72ppm. The strategy has been applied on samples seized in different times and places in Naples (Italy). The chemical {"}fingerprint{"} depend on what plant they were extracted from, where it was cultivated, and which procedures were used for extraction and purification, thus adding significant information in the process toward identification of the trafficking routes for this drug.",

author = "Bruno Pagano and Ilaria Lauri and {De Tito}, Stefano and Guido Persico and Chini, {Maria Giovanna} and Anders Malmendal and Ettore Novellino and Antonio Randazzo",

year = "2013",

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doi = "10.1016/j.forsciint.2013.04.028",

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journal = "Forensic Science International",

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T1 - Use of NMR in profiling of cocaine seizures

AU - Pagano, Bruno

AU - Lauri, Ilaria

AU - De Tito, Stefano

AU - Persico, Guido

AU - Chini, Maria Giovanna

AU - Malmendal, Anders

AU - Novellino, Ettore

AU - Randazzo, Antonio

PY - 2013/9/10

Y1 - 2013/9/10

N2 - Cocaine is the most widely used illicit drug, and its origin is always the focus of intense investigation aimed at identifying the trafficking routes. Since NMR represents a unique methodology for performing chemical identification and quantification, here it is proposed a strategy based on (1)H NMR spectral analysis in conjunction with multivariate analysis to identify the chemical "fingerprint" of cocaine samples, and to link cocaine samples based on this information. The most relevant spectral regions containing the fingerprint have been identified: δH 0.86-0.96, 1.50-1.56, 5.90-5.93, 6.48-6.52, 7.31-7.34, 7.61-7.63, 7.68-7.72ppm. The strategy has been applied on samples seized in different times and places in Naples (Italy). The chemical "fingerprint" depend on what plant they were extracted from, where it was cultivated, and which procedures were used for extraction and purification, thus adding significant information in the process toward identification of the trafficking routes for this drug.

AB - Cocaine is the most widely used illicit drug, and its origin is always the focus of intense investigation aimed at identifying the trafficking routes. Since NMR represents a unique methodology for performing chemical identification and quantification, here it is proposed a strategy based on (1)H NMR spectral analysis in conjunction with multivariate analysis to identify the chemical "fingerprint" of cocaine samples, and to link cocaine samples based on this information. The most relevant spectral regions containing the fingerprint have been identified: δH 0.86-0.96, 1.50-1.56, 5.90-5.93, 6.48-6.52, 7.31-7.34, 7.61-7.63, 7.68-7.72ppm. The strategy has been applied on samples seized in different times and places in Naples (Italy). The chemical "fingerprint" depend on what plant they were extracted from, where it was cultivated, and which procedures were used for extraction and purification, thus adding significant information in the process toward identification of the trafficking routes for this drug.

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DO - 10.1016/j.forsciint.2013.04.028

M3 - Journal article

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EP - 124

JO - Forensic Science International

JF - Forensic Science International

IS - 1-3

ER -

Use of NMR in profiling of cocaine seizures

Abstract

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