@article{26d489e0ac0511ddb5e9000ea68e967b,
title = "Treatment of transplanted CT26 tumour with dendritic cell vaccine in combination with blockade of vascular endothelial growth factor receptor 2 and CTLA-4.",
abstract = "We investigated the anti CT26 tumour effect of dendritic cell based vaccination with the MuLV gp70 envelope protein-derived peptides AH1 and p320-333. Vaccination lead to generation of AH1 specific cytotoxic lymphocytes (CTL) and some decrease in tumour growth of simultaneously inoculated CT26 cells. After combination with an antibody against VEGF receptor 2 (DC101), a significant increase in survival of the tumour cell recipients was observed. Also, monotherapy with an antibody against CTLA-4 (9H10), led to approximately 100% survival of tumour cell recipients. However, effective treatment of mice with already established tumours was only obtained after combination of vaccination, DC101 and 9H10 treatment in which setting 80% of the mice rejected their tumours.",
author = "Pedersen, {Anders Elm} and S Buus and Claesson, {M H}",
note = "Keywords: Animals; Antigens, CD; Antigens, Differentiation; Colonic Neoplasms; Combined Modality Therapy; Dendritic Cells; Epitopes, T-Lymphocyte; Female; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; T-Lymphocytes, Cytotoxic; Vaccination; Vaccines; Vascular Endothelial Growth Factor Receptor-2",
year = "2005",
doi = "10.1016/j.canlet.2005.04.012",
language = "English",
volume = "235",
pages = "229--38",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2",
}
