TY - JOUR
T1 - Transferring substrates to the 26S proteasome.
AU - Hartmann-Petersen, Rasmus
AU - Seeger, Michael
AU - Gordon, Colin
N1 - Keywords: Cysteine Endopeptidases; Molecular Chaperones; Multienzyme Complexes; Proteasome Endopeptidase Complex; Substrate Specificity; Ubiquitin
PY - 2003
Y1 - 2003
N2 - Ubiquitin-dependent protein degradation is not only involved in the recycling of amino acids from damaged or misfolded proteins but also represents an essential and deftly controlled mechanism for modulating the levels of key regulatory proteins. Chains of ubiquitin conjugated to a substrate protein specifically target it for degradation by the 26S proteasome, a huge multi-subunit protein complex found in all eukaryotic cells. Recent reports have clarified some of the molecular mechanisms involved in the transfer of ubiquitinated substrates from the ubiquitination machinery to the proteasome. This novel substrate transportation step in the ubiquitin-proteasome pathway seems to occur either directly or indirectly via certain substrate-recruiting proteins and appears to involve chaperones.
AB - Ubiquitin-dependent protein degradation is not only involved in the recycling of amino acids from damaged or misfolded proteins but also represents an essential and deftly controlled mechanism for modulating the levels of key regulatory proteins. Chains of ubiquitin conjugated to a substrate protein specifically target it for degradation by the 26S proteasome, a huge multi-subunit protein complex found in all eukaryotic cells. Recent reports have clarified some of the molecular mechanisms involved in the transfer of ubiquitinated substrates from the ubiquitination machinery to the proteasome. This novel substrate transportation step in the ubiquitin-proteasome pathway seems to occur either directly or indirectly via certain substrate-recruiting proteins and appears to involve chaperones.
U2 - 10.1016/S0968-0004(02)00002-6
DO - 10.1016/S0968-0004(02)00002-6
M3 - Journal article
C2 - 12517449
SN - 0968-0004
VL - 28
SP - 26
EP - 31
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 1
ER -