Toxin synergism in snake venoms

Andreas Hougaard Laustsen

doi:10.1080/15569543.2016.1220397

Toxin synergism in snake venoms

Andreas Hougaard Laustsen^*

^*Corresponding author af dette arbejde

25 Citationer (Scopus)

Abstract

Synergism between venom toxins exists for a range of snake species. Synergism can be derived from both intermolecular interactions and supramolecular interactions between venom components, and can be the result of toxins targeting the same protein, biochemical pathway or physiological process. Few simple systematic tools and methods for determining the presence of synergism exist, but include co-administration of venom components and assessment of Accumulated Toxicity Scores. A better understanding of how to investigate synergism in snake venoms may help unravel strategies for developing novel therapies against snakebite envenoming by elucidating mechanisms for toxicity and interactions between venom components.

Originalsprog	Engelsk
Tidsskrift	Toxin Reviews
Vol/bind	35
Udgave nummer	3-4
Sider (fra-til)	165-170
Antal sider	6
ISSN	1556-9543
DOI	https://doi.org/10.1080/15569543.2016.1220397
Status	Udgivet - 2016

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10.1080/15569543.2016.1220397

Citationsformater

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title = "Toxin synergism in snake venoms",

abstract = "Synergism between venom toxins exists for a range of snake species. Synergism can be derived from both intermolecular interactions and supramolecular interactions between venom components, and can be the result of toxins targeting the same protein, biochemical pathway or physiological process. Few simple systematic tools and methods for determining the presence of synergism exist, but include co-administration of venom components and assessment of Accumulated Toxicity Scores. A better understanding of how to investigate synergism in snake venoms may help unravel strategies for developing novel therapies against snakebite envenoming by elucidating mechanisms for toxicity and interactions between venom components.",

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AB - Synergism between venom toxins exists for a range of snake species. Synergism can be derived from both intermolecular interactions and supramolecular interactions between venom components, and can be the result of toxins targeting the same protein, biochemical pathway or physiological process. Few simple systematic tools and methods for determining the presence of synergism exist, but include co-administration of venom components and assessment of Accumulated Toxicity Scores. A better understanding of how to investigate synergism in snake venoms may help unravel strategies for developing novel therapies against snakebite envenoming by elucidating mechanisms for toxicity and interactions between venom components.

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KW - intermolecular synergism

KW - snake toxins

KW - snake venom

KW - supramolecular synergism

KW - toxicity score

KW - Toxin synergism

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DO - 10.1080/15569543.2016.1220397

M3 - Review

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SN - 1556-9543

VL - 35

SP - 165

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JO - Toxin Reviews

JF - Toxin Reviews

IS - 3-4

ER -

Toxin synergism in snake venoms

Abstract

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