The role of p53 and pRB in apoptosis and cancer.

TY - JOUR

T1 - The role of p53 and pRB in apoptosis and cancer.

AU - Hickman, Emma S

AU - Moroni, M Cristina

AU - Helin, Kristian

N1 - Keywords: Animals; Apoptosis; Cell Cycle Proteins; DNA-Binding Proteins; E2F Transcription Factors; Gene Expression Profiling; Genes, Tumor Suppressor; Humans; Inhibitor of Differentiation Protein 2; Mice; Neoplasms; Repressor Proteins; Retinoblastoma Protein; Transcription Factors; Tumor Suppressor Protein p53

PY - 2002

Y1 - 2002

N2 - Loss of function of both the p53 pathway and the retinoblastoma protein (pRB) pathway plays a significant role in the development of most human cancers. Loss of pRB results in deregulated cell proliferation and apoptosis, whereas loss of p53 desensitizes cells to checkpoint signals, including apoptosis. In the past two years, mouse genetics and gene expression profiling have led to major advances in our understanding of how the pRB and p53 pathways regulate apoptosis and thus the development of tumours.

AB - Loss of function of both the p53 pathway and the retinoblastoma protein (pRB) pathway plays a significant role in the development of most human cancers. Loss of pRB results in deregulated cell proliferation and apoptosis, whereas loss of p53 desensitizes cells to checkpoint signals, including apoptosis. In the past two years, mouse genetics and gene expression profiling have led to major advances in our understanding of how the pRB and p53 pathways regulate apoptosis and thus the development of tumours.

M3 - Review

C2 - 11790556

SN - 0959-437X

VL - 12

SP - 60

EP - 66

JO - Current Opinion in Genetics & Development

JF - Current Opinion in Genetics & Development

IS - 1

ER -