The OMERACT MRI in Arthritis Working Group - Update on Status and Future Research Priorities

Mikkel Østergaard; Paul Bird; Frédérique Gandjbakhch; Iris Eshed; Ida K Haugen; Espen A Haavardsholm; Siri Lillegraven; Violaine Foltz; Daniel Glinatsi; Charles Peterfy; Bo Ejbjerg; Pernille Bøyesen; Philip J Mease; Kay-Geert Hermann; Paul Emery; Harry K Genant; Philip G Conaghan

doi:10.3899/jrheum.141248

The OMERACT MRI in Arthritis Working Group - Update on Status and Future Research Priorities

Mikkel Østergaard, Paul Bird, Frédérique Gandjbakhch, Iris Eshed, Ida K Haugen, Espen A Haavardsholm, Siri Lillegraven, Violaine Foltz, Daniel Glinatsi, Charles Peterfy, Bo Ejbjerg, Pernille Bøyesen, Philip J Mease, Kay-Geert Hermann, Paul Emery, Harry K Genant, Philip G Conaghan

Institut for Klinisk Medicin

14 Citationer (Scopus)

Abstract

OBJECTIVE: To provide an update on the status and future research priorities of the Outcome Measures in Rheumatology (OMERACT) magnetic resonance imaging (MRI) in arthritis working group.

METHODS: A summary is provided of the activities of the group within rheumatoid arthritis (RA), psoriatic arthritis (PsA), and osteoarthritis (OA), and its research priorities.

RESULTS: The OMERACT RA MRI score (RAMRIS) evaluating bone erosion, bone edema (osteitis), and synovitis is now the standard method of quantifying articular pathology in RA trials. Cartilage loss is another important part of joint damage, and at the OMERACT 12 conference, we provided longitudinal data demonstrating reliability and sensitivity to change of the RAMRIS JSN component score, supporting its use in future clinical trials. The MRI group has previously developed a PsA MRI score (PsAMRIS). At OMERACT 12, PsAMRIS was evaluated in a randomized placebo-controlled trial of patients with PsA, demonstrating the responsiveness and discriminatory ability of applying the PsAMRIS to hands and feet. A hand OA MRI score (HOAMRIS) was introduced at OMERACT 11, and has subsequently been further validated. At OMERACT 12, good cross-sectional interreader reliability, but variable reliability of change scores, were reported. Potential future research areas were identified at the MRI session at OMERACT 12 including assessment of tenosynovitis in RA and enthesitis in PsA and focusing on alternative MRI techniques.

CONCLUSION: MRI has been further developed and validated as an outcome measure in RA, PsA, and OA. The group will continue its efforts to optimize the value of MRI as a robust biomarker in rheumatology clinical trials.

Originalsprog	Engelsk
Tidsskrift	Journal of Rheumatology
Vol/bind	42
Udgave nummer	12
Sider (fra-til)	2470-2
Antal sider	3
ISSN	0315-162X
DOI	https://doi.org/10.3899/jrheum.141248
Status	Udgivet - dec. 2015

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10.3899/jrheum.141248

https://www.jrheum.org/content/jrheum/42/12/2470.full.pdf

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Østergaard, M., Bird, P., Gandjbakhch, F., Eshed, I., Haugen, I. K., Haavardsholm, E. A., Lillegraven, S., Foltz, V., Glinatsi, D., Peterfy, C., Ejbjerg, B., Bøyesen, P., Mease, P. J., Hermann, K-G., Emery, P., Genant, H. K., & Conaghan, P. G. (2015). The OMERACT MRI in Arthritis Working Group - Update on Status and Future Research Priorities. Journal of Rheumatology, 42(12), 2470-2. https://doi.org/10.3899/jrheum.141248

Østergaard, M, Bird, P, Gandjbakhch, F, Eshed, I, Haugen, IK, Haavardsholm, EA, Lillegraven, S, Foltz, V, Glinatsi, D, Peterfy, C, Ejbjerg, B, Bøyesen, P, Mease, PJ, Hermann, K-G, Emery, P, Genant, HK & Conaghan, PG 2015, 'The OMERACT MRI in Arthritis Working Group - Update on Status and Future Research Priorities', Journal of Rheumatology, bind 42, nr. 12, s. 2470-2. https://doi.org/10.3899/jrheum.141248

@article{136420de8b99437384faad02ccdd3787,

title = "The OMERACT MRI in Arthritis Working Group - Update on Status and Future Research Priorities",

abstract = "OBJECTIVE: To provide an update on the status and future research priorities of the Outcome Measures in Rheumatology (OMERACT) magnetic resonance imaging (MRI) in arthritis working group.METHODS: A summary is provided of the activities of the group within rheumatoid arthritis (RA), psoriatic arthritis (PsA), and osteoarthritis (OA), and its research priorities.RESULTS: The OMERACT RA MRI score (RAMRIS) evaluating bone erosion, bone edema (osteitis), and synovitis is now the standard method of quantifying articular pathology in RA trials. Cartilage loss is another important part of joint damage, and at the OMERACT 12 conference, we provided longitudinal data demonstrating reliability and sensitivity to change of the RAMRIS JSN component score, supporting its use in future clinical trials. The MRI group has previously developed a PsA MRI score (PsAMRIS). At OMERACT 12, PsAMRIS was evaluated in a randomized placebo-controlled trial of patients with PsA, demonstrating the responsiveness and discriminatory ability of applying the PsAMRIS to hands and feet. A hand OA MRI score (HOAMRIS) was introduced at OMERACT 11, and has subsequently been further validated. At OMERACT 12, good cross-sectional interreader reliability, but variable reliability of change scores, were reported. Potential future research areas were identified at the MRI session at OMERACT 12 including assessment of tenosynovitis in RA and enthesitis in PsA and focusing on alternative MRI techniques.CONCLUSION: MRI has been further developed and validated as an outcome measure in RA, PsA, and OA. The group will continue its efforts to optimize the value of MRI as a robust biomarker in rheumatology clinical trials.",

author = "Mikkel {\O}stergaard and Paul Bird and Fr{\'e}d{\'e}rique Gandjbakhch and Iris Eshed and Haugen, {Ida K} and Haavardsholm, {Espen A} and Siri Lillegraven and Violaine Foltz and Daniel Glinatsi and Charles Peterfy and Bo Ejbjerg and Pernille B{\o}yesen and Mease, {Philip J} and Kay-Geert Hermann and Paul Emery and Genant, {Harry K} and Conaghan, {Philip G}",

year = "2015",

month = dec,

doi = "10.3899/jrheum.141248",

language = "English",

volume = "42",

pages = "2470--2",

journal = "Journal of Rheumatology",

issn = "0315-162X",

publisher = "Journal of Rheumatology Publishing Co. Ltd.",

number = "12",

}

TY - JOUR

T1 - The OMERACT MRI in Arthritis Working Group - Update on Status and Future Research Priorities

AU - Østergaard, Mikkel

AU - Bird, Paul

AU - Gandjbakhch, Frédérique

AU - Eshed, Iris

AU - Haugen, Ida K

AU - Haavardsholm, Espen A

AU - Lillegraven, Siri

AU - Foltz, Violaine

AU - Glinatsi, Daniel

AU - Peterfy, Charles

AU - Ejbjerg, Bo

AU - Bøyesen, Pernille

AU - Mease, Philip J

AU - Hermann, Kay-Geert

AU - Emery, Paul

AU - Genant, Harry K

AU - Conaghan, Philip G

PY - 2015/12

Y1 - 2015/12

N2 - OBJECTIVE: To provide an update on the status and future research priorities of the Outcome Measures in Rheumatology (OMERACT) magnetic resonance imaging (MRI) in arthritis working group.METHODS: A summary is provided of the activities of the group within rheumatoid arthritis (RA), psoriatic arthritis (PsA), and osteoarthritis (OA), and its research priorities.RESULTS: The OMERACT RA MRI score (RAMRIS) evaluating bone erosion, bone edema (osteitis), and synovitis is now the standard method of quantifying articular pathology in RA trials. Cartilage loss is another important part of joint damage, and at the OMERACT 12 conference, we provided longitudinal data demonstrating reliability and sensitivity to change of the RAMRIS JSN component score, supporting its use in future clinical trials. The MRI group has previously developed a PsA MRI score (PsAMRIS). At OMERACT 12, PsAMRIS was evaluated in a randomized placebo-controlled trial of patients with PsA, demonstrating the responsiveness and discriminatory ability of applying the PsAMRIS to hands and feet. A hand OA MRI score (HOAMRIS) was introduced at OMERACT 11, and has subsequently been further validated. At OMERACT 12, good cross-sectional interreader reliability, but variable reliability of change scores, were reported. Potential future research areas were identified at the MRI session at OMERACT 12 including assessment of tenosynovitis in RA and enthesitis in PsA and focusing on alternative MRI techniques.CONCLUSION: MRI has been further developed and validated as an outcome measure in RA, PsA, and OA. The group will continue its efforts to optimize the value of MRI as a robust biomarker in rheumatology clinical trials.

AB - OBJECTIVE: To provide an update on the status and future research priorities of the Outcome Measures in Rheumatology (OMERACT) magnetic resonance imaging (MRI) in arthritis working group.METHODS: A summary is provided of the activities of the group within rheumatoid arthritis (RA), psoriatic arthritis (PsA), and osteoarthritis (OA), and its research priorities.RESULTS: The OMERACT RA MRI score (RAMRIS) evaluating bone erosion, bone edema (osteitis), and synovitis is now the standard method of quantifying articular pathology in RA trials. Cartilage loss is another important part of joint damage, and at the OMERACT 12 conference, we provided longitudinal data demonstrating reliability and sensitivity to change of the RAMRIS JSN component score, supporting its use in future clinical trials. The MRI group has previously developed a PsA MRI score (PsAMRIS). At OMERACT 12, PsAMRIS was evaluated in a randomized placebo-controlled trial of patients with PsA, demonstrating the responsiveness and discriminatory ability of applying the PsAMRIS to hands and feet. A hand OA MRI score (HOAMRIS) was introduced at OMERACT 11, and has subsequently been further validated. At OMERACT 12, good cross-sectional interreader reliability, but variable reliability of change scores, were reported. Potential future research areas were identified at the MRI session at OMERACT 12 including assessment of tenosynovitis in RA and enthesitis in PsA and focusing on alternative MRI techniques.CONCLUSION: MRI has been further developed and validated as an outcome measure in RA, PsA, and OA. The group will continue its efforts to optimize the value of MRI as a robust biomarker in rheumatology clinical trials.

U2 - 10.3899/jrheum.141248

DO - 10.3899/jrheum.141248

M3 - Journal article

C2 - 25684771

SN - 0315-162X

VL - 42

SP - 2470

EP - 2472

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 12

ER -

The OMERACT MRI in Arthritis Working Group - Update on Status and Future Research Priorities

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