TY - CHAP
T1 - The Lectin Pathway of Complement and Biocompatibility
AU - Hein, Estrid
AU - Garred, Peter
PY - 2015
Y1 - 2015
N2 - In modern health technologies the use of biomaterials in the form of stents, haemodialysis tubes, artificial implants, bypass circuits etc. is rapidly expanding. The exposure of synthetic, foreign surfaces to the blood and tissue of the host, calls for strict biocompatibility in respect to contact activation, the coagulation system and the complement system. The complement system is an important part of the initial immune response and consists of fluid phase molecules in the blood stream. Three different activation pathways can initiate the complement system, the lectin, the classical and the alternative pathway, all converging in an amplification loop of the cascade system and downstream reactions. Thus, when exposed to foreign substances complement components will be activated and lead to a powerful inflammatory response. Biosurface induced complement activation is a recognised issue that has been broadly documented. However, the specific role of lectin pathway and the pattern recognition molecules initiating the pathway has only been transiently investigated. Here we review the current data on the field.
AB - In modern health technologies the use of biomaterials in the form of stents, haemodialysis tubes, artificial implants, bypass circuits etc. is rapidly expanding. The exposure of synthetic, foreign surfaces to the blood and tissue of the host, calls for strict biocompatibility in respect to contact activation, the coagulation system and the complement system. The complement system is an important part of the initial immune response and consists of fluid phase molecules in the blood stream. Three different activation pathways can initiate the complement system, the lectin, the classical and the alternative pathway, all converging in an amplification loop of the cascade system and downstream reactions. Thus, when exposed to foreign substances complement components will be activated and lead to a powerful inflammatory response. Biosurface induced complement activation is a recognised issue that has been broadly documented. However, the specific role of lectin pathway and the pattern recognition molecules initiating the pathway has only been transiently investigated. Here we review the current data on the field.
KW - Biocompatible Materials
KW - Blood Coagulation
KW - Blood Coagulation Factors
KW - Collectins
KW - Complement Activation
KW - Complement Pathway, Mannose-Binding Lectin
KW - Extracorporeal Circulation
KW - Gene Expression Regulation
KW - Humans
KW - Lectins
KW - Mannose-Binding Protein-Associated Serine Proteases
KW - Protein Binding
KW - Receptors, Pattern Recognition
KW - Signal Transduction
KW - Surface Properties
U2 - 10.1007/978-3-319-18603-0_5
DO - 10.1007/978-3-319-18603-0_5
M3 - Book chapter
C2 - 26306444
SN - 978-3-319-18602-3
VL - 865
T3 - Advances in Experimental Medicine and Biology
SP - 77
EP - 92
BT - Immune Responses to Biosurfaces
PB - Springer
ER -