The lectin pathway of complement: Advantage or disadvantage in HIV pathogenesis?

TY - JOUR

T1 - The lectin pathway of complement

T2 - Advantage or disadvantage in HIV pathogenesis?

AU - Ballegaard, Vibe Cecilie Diederich

AU - Haugaard, Anna Karen

AU - Garred, P

AU - Nielsen, Susanne Dam

AU - Munthe-Fog, L

N1 - Copyright © 2014 Elsevier Inc. All rights reserved.

PY - 2014/9

Y1 - 2014/9

N2 - The pattern recognition molecules of the lectin complement pathway are important components of the innate immune system with known functions in host-virus interactions. This paper summarizes current knowledge of how these intriguing molecules, including mannose-binding lectin (MBL), Ficolin-1, -2 and -3, and collectin-11 (CL-11) may influence HIV-pathogenesis. It has been demonstrated that MBL is capable of binding and neutralizing HIV and may affect host susceptibility to HIV infection and disease progression. In addition, MBL may cause variations in the host immune response against HIV. Ficolin-1, -2 and -3 and CL-11 could have similar functions in HIV infection as the ficolins have been shown to play a role in other viral infections, and CL-11 resembles MBL and the ficolins in structure and binding capacity.

AB - The pattern recognition molecules of the lectin complement pathway are important components of the innate immune system with known functions in host-virus interactions. This paper summarizes current knowledge of how these intriguing molecules, including mannose-binding lectin (MBL), Ficolin-1, -2 and -3, and collectin-11 (CL-11) may influence HIV-pathogenesis. It has been demonstrated that MBL is capable of binding and neutralizing HIV and may affect host susceptibility to HIV infection and disease progression. In addition, MBL may cause variations in the host immune response against HIV. Ficolin-1, -2 and -3 and CL-11 could have similar functions in HIV infection as the ficolins have been shown to play a role in other viral infections, and CL-11 resembles MBL and the ficolins in structure and binding capacity.

KW - Complement Pathway, Mannose-Binding Lectin

KW - HIV Infections

KW - Humans

KW - Models, Biological

KW - Polymorphism, Genetic

U2 - 10.1016/j.clim.2014.06.002

DO - 10.1016/j.clim.2014.06.002

M3 - Review

C2 - 24928325

SN - 1521-6616

VL - 154

SP - 13

EP - 25

JO - Clinical Immunology

JF - Clinical Immunology

IS - 1

ER -