TY - JOUR
T1 - The high throughput biomedicine unit at the institute for molecular medicine Finland
T2 - high throughput screening meets precision medicine
AU - Pietiainen, Vilja
AU - Saarela, Jani
AU - von Schantz, Carina
AU - Turunen, Laura
AU - Ostling, Paivi
AU - Wennerberg, Krister
PY - 2014/5
Y1 - 2014/5
N2 - The High Throughput Biomedicine (HTB) unit at the Institute for Molecular Medicine Finland FIMM was established in 2010 to serve as a national and international academic screening unit providing access to state of the art instrumentation for chemical and RNAi-based high throughput screening. The initial focus of the unit was multiwell plate based chemical screening and high content microarray-based siRNA screening. However, over the first four years of operation, the unit has moved to a more flexible service platform where both chemical and siRNA screening is performed at different scales primarily in multiwell plate-based assays with a wide range of readout possibilities with a focus on ultraminiaturization to allow for affordable screening for the academic users. In addition to high throughput screening, the equipment of the unit is also used to support miniaturized, multiplexed and high throughput applications for other types of research such as genomics, sequencing and biobanking operations. Importantly, with the translational research goals at FIMM, an increasing part of the operations at the HTB unit is being focused on high throughput systems biological platforms for functional profiling of patient cells in personalized and precision medicine projects.
AB - The High Throughput Biomedicine (HTB) unit at the Institute for Molecular Medicine Finland FIMM was established in 2010 to serve as a national and international academic screening unit providing access to state of the art instrumentation for chemical and RNAi-based high throughput screening. The initial focus of the unit was multiwell plate based chemical screening and high content microarray-based siRNA screening. However, over the first four years of operation, the unit has moved to a more flexible service platform where both chemical and siRNA screening is performed at different scales primarily in multiwell plate-based assays with a wide range of readout possibilities with a focus on ultraminiaturization to allow for affordable screening for the academic users. In addition to high throughput screening, the equipment of the unit is also used to support miniaturized, multiplexed and high throughput applications for other types of research such as genomics, sequencing and biobanking operations. Importantly, with the translational research goals at FIMM, an increasing part of the operations at the HTB unit is being focused on high throughput systems biological platforms for functional profiling of patient cells in personalized and precision medicine projects.
KW - Biological Specimen Banks
KW - Cooperative Behavior
KW - Drug Discovery/methods
KW - Europe
KW - Finland
KW - Genomics/methods
KW - High-Throughput Screening Assays
KW - Humans
KW - Microscopy
KW - Molecular Medicine/manpower
KW - Precision Medicine/methods
KW - RNA Interference
KW - RNA, Small Interfering
KW - Translational Medical Research/organization & administration
M3 - Journal article
C2 - 24661208
SN - 1386-2073
VL - 17
SP - 377
EP - 386
JO - Combinatorial Chemistry and High Throughput Screening
JF - Combinatorial Chemistry and High Throughput Screening
IS - 4
ER -