Abstract
OBJECTIVE: Glucagon-like peptide-1 (GLP-1 (7-36)amide) is an intestinal hormone that is released in response to meal ingestion. GLP-1 reduces postprandial gastric and exocrine pancreatic secretion and is believed to inhibit gastric emptying. Furthermore, GLP-1 may play a role in hunger and thirst regulation. In vivo, GLP-1 is rapidly (within minutes) converted into a metabolite, GLP-1 (9-36)amide, which has been shown to act as a GLP-1 receptor antagonist in vitro and in anaesthetized pigs. The purpose of this study was to assess the effect of infusion of GLP-1 (9-36)amide on hunger ratings and antral emptying of a meal.
MATERIAL AND METHODS: Six healthy volunteers were tested in a double-blind, placebo-controlled fashion. Antral emptying of a liquid meal and hunger ratings were determined using ultrasound technology and visual analogue scale scoring during infusions of saline or GLP-1 (9-36)amide (5 pmol/kg body wt/min) resulting in supraphysiological concentrations.
RESULTS: Infusion of GLP-1 (9-36)amide had no effect on gastric emptying or the sensation of hunger compared to saline.
CONCLUSIONS: Our findings suggests that the rapid formation of the antagonistic metabolite does not influence gastric emptying and hunger ratings in humans even when it is present in supraphysiological concentrations.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Scandinavian Journal of Gastroenterology |
| Vol/bind | 42 |
| Udgave nummer | 1 |
| Sider (fra-til) | 28-33 |
| Antal sider | 6 |
| ISSN | 0036-5521 |
| DOI | |
| Status | Udgivet - jan. 2007 |