Testosterone in ancient hair from an extinct species

Lee Koren; Devorah Matas; Patrícia Pečnerová; Love Dalén; Alexei Tikhonov; M. Thomas P. Gilbert; Katherine E. Wynne-edwards; Eli Geffen

doi:10.1111/pala.2018.61.issue-6

Testosterone in ancient hair from an extinct species

Lee Koren, Devorah Matas, Patrícia Pečnerová, Love Dalén, Alexei Tikhonov, M. Thomas P. Gilbert, Katherine E. Wynne-edwards, Eli Geffen

4 Citationer (Scopus)

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Abstract

Testosterone is a key regulator in vertebrate development, physiology and behaviour. Whereas technology allows extraction of a wealth of genetic information from extant as well as extinct species, complementary information on steroid hormone levels may add a social, sexual and environmental context. Hair shafts have been previously used to sequence DNA from >50 000 ¹⁴C years old Siberian woolly mammoths (Mammuthus primigenius). Hair-testing has also been used to measure endogenous steroids in multiple extant species. Here we use small quantities of woolly mammoth hair samples to measure testosterone, and a genomics-based approach to determine sex, in permafrost-preserved mammoths dated to c. 10 000–60 000 ¹⁴C years. Our validated method opens up exciting opportunities to measure multiple steroids in keratinized tissues from extinct populations of mammals. This may be specifically applied to investigating life histories, including the extinct Quaternary megafauna populations whose remains are preserved in the permafrost throughout the northern hemisphere.

Originalsprog	Engelsk
Bogserie	Special Papers in Palaeontology
Vol/bind	61
Udgave nummer	6
Sider (fra-til)	797-802
ISSN	0031-0239
DOI	https://doi.org/10.1111/pala.2018.61.issue-6
Status	Udgivet - 1 nov. 2018

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10.1111/pala.2018.61.issue-6Licens: CC BY

Koren_et_al-2018-PalaeontologyForlagets udgivne version, 190 KBLicens: CC BY

Citationsformater

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AU - Matas, Devorah

AU - Pečnerová, Patrícia

AU - Dalén, Love

AU - Tikhonov, Alexei

AU - Gilbert, M. Thomas P.

AU - Wynne-edwards, Katherine E.

AU - Geffen, Eli

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AB - Testosterone is a key regulator in vertebrate development, physiology and behaviour. Whereas technology allows extraction of a wealth of genetic information from extant as well as extinct species, complementary information on steroid hormone levels may add a social, sexual and environmental context. Hair shafts have been previously used to sequence DNA from >50 000 14C years old Siberian woolly mammoths (Mammuthus primigenius). Hair-testing has also been used to measure endogenous steroids in multiple extant species. Here we use small quantities of woolly mammoth hair samples to measure testosterone, and a genomics-based approach to determine sex, in permafrost-preserved mammoths dated to c. 10 000–60 000 14C years. Our validated method opens up exciting opportunities to measure multiple steroids in keratinized tissues from extinct populations of mammals. This may be specifically applied to investigating life histories, including the extinct Quaternary megafauna populations whose remains are preserved in the permafrost throughout the northern hemisphere.

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DO - 10.1111/pala.2018.61.issue-6

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JO - Special Papers in Palaeontology

JF - Special Papers in Palaeontology

IS - 6

ER -

Testosterone in ancient hair from an extinct species

Abstract

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