@article{96f7b410040f11deb05e000ea68e967b,
title = "Targeting of microRNAs for therapeutics",
abstract = "miRNAs (microRNAs) comprise a class of small endogenous non-coding RNAs that post-transcriptionally repress gene expression by base-pairing with their target mRNAs. Recent evidence has shown that miRNAs play important roles in a wide variety of human diseases, such as viral infections, cancer and cardiovascular diseases, and thus miRNAs have rapidly emerged as potential targets for therapeutics. LNAs (locked nucleic acids) comprise a class of bicyclic conformational analogues of RNA, which exhibit high binding affinity to complementary RNA molecules and high stability in blood and tissues in vivo. Recent reports on LNA-mediated miRNA silencing in rodents and primates support the potential of LNA-modified oligonucleotides in studying miRNA functions in vivo and in the future development of miRNA-based therapeutics.",
author = "Jan Stenvang and Morten Lindow and Sakari Kauppinen",
note = "Keywords: Animals; Disease; Humans; Mice; MicroRNAs; Oligonucleotides; Primates",
year = "2008",
doi = "10.1042/BST0361197",
language = "English",
volume = "36",
pages = "1197--200",
journal = "Biochemical Society Transactions",
issn = "0300-5127",
publisher = "Portland Press Ltd.",
number = "Pt 6",
}
