T-cell transfer and cytokine/TCR gene deletion models in the study of inflammatory bowel disease

S Bregenholt; D Delbro; Mogens Helweg Claesson

T-cell transfer and cytokine/TCR gene deletion models in the study of inflammatory bowel disease

S Bregenholt, D Delbro, Mogens Helweg Claesson

LUKKET: Institut for Immunologi og Mikrobiologi

21 Citationer (Scopus)

Abstract

Until recently there existed no appropriate immunological animal models for human inflammatory bowel diseases (IBD). Today a number of models, mostly in the mouse and rat, have proved useful in the study of several aspects of IBD, including the histopathology and the disease-inductive and -protective cell types, subsets and cytokines, for example CD4+ T cells, IFN gamma, IL-12, IL-2, IL-10 and TGF beta. Furthermore, these recent IBD models make it possible to examine various chemo- and immunotherapeutic approaches. This review focuses on IBD development in adoptive T-cell transfer models and in gene-deleted mice.

Originalsprog	Engelsk
Tidsskrift	Acta Pathologica Microbiologica et Immunologica Scandinavica
Vol/bind	105
Udgave nummer	9
Sider (fra-til)	655-662
Antal sider	8
ISSN	0903-4641
Status	Udgivet - 1997

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Citationsformater

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title = "T-cell transfer and cytokine/TCR gene deletion models in the study of inflammatory bowel disease",

abstract = "Until recently there existed no appropriate immunological animal models for human inflammatory bowel diseases (IBD). Today a number of models, mostly in the mouse and rat, have proved useful in the study of several aspects of IBD, including the histopathology and the disease-inductive and -protective cell types, subsets and cytokines, for example CD4+ T cells, IFN gamma, IL-12, IL-2, IL-10 and TGF beta. Furthermore, these recent IBD models make it possible to examine various chemo- and immunotherapeutic approaches. This review focuses on IBD development in adoptive T-cell transfer models and in gene-deleted mice.",

keywords = "Animals, B-Lymphocytes, CD4-Positive T-Lymphocytes, Cytokines, Disease Models, Animal, GTP-Binding Protein alpha Subunits, Gi-Go, Gene Deletion, Genes, T-Cell Receptor, Immunity, Mucosal, Immunization, Passive, Inflammatory Bowel Diseases, Interleukin-10, Mice, Mice, Knockout, Mice, SCID, Rats, T-Lymphocytes",

author = "S Bregenholt and D Delbro and Claesson, {Mogens Helweg}",

year = "1997",

language = "English",

volume = "105",

pages = "655--662",

journal = "APMIS. Supplementum",

issn = "0903-465X",

publisher = "Wiley Online",

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TY - JOUR

T1 - T-cell transfer and cytokine/TCR gene deletion models in the study of inflammatory bowel disease

AU - Bregenholt, S

AU - Delbro, D

AU - Claesson, Mogens Helweg

PY - 1997

Y1 - 1997

N2 - Until recently there existed no appropriate immunological animal models for human inflammatory bowel diseases (IBD). Today a number of models, mostly in the mouse and rat, have proved useful in the study of several aspects of IBD, including the histopathology and the disease-inductive and -protective cell types, subsets and cytokines, for example CD4+ T cells, IFN gamma, IL-12, IL-2, IL-10 and TGF beta. Furthermore, these recent IBD models make it possible to examine various chemo- and immunotherapeutic approaches. This review focuses on IBD development in adoptive T-cell transfer models and in gene-deleted mice.

AB - Until recently there existed no appropriate immunological animal models for human inflammatory bowel diseases (IBD). Today a number of models, mostly in the mouse and rat, have proved useful in the study of several aspects of IBD, including the histopathology and the disease-inductive and -protective cell types, subsets and cytokines, for example CD4+ T cells, IFN gamma, IL-12, IL-2, IL-10 and TGF beta. Furthermore, these recent IBD models make it possible to examine various chemo- and immunotherapeutic approaches. This review focuses on IBD development in adoptive T-cell transfer models and in gene-deleted mice.

KW - Animals

KW - B-Lymphocytes

KW - CD4-Positive T-Lymphocytes

KW - Cytokines

KW - Disease Models, Animal

KW - GTP-Binding Protein alpha Subunits, Gi-Go

KW - Gene Deletion

KW - Genes, T-Cell Receptor

KW - Immunity, Mucosal

KW - Immunization, Passive

KW - Inflammatory Bowel Diseases

KW - Interleukin-10

KW - Mice

KW - Mice, Knockout

KW - Mice, SCID

KW - Rats

KW - T-Lymphocytes

M3 - Journal article

C2 - 9350208

SN - 0903-465X

VL - 105

SP - 655

EP - 662

JO - APMIS. Supplementum

JF - APMIS. Supplementum

IS - 9

ER -

T-cell transfer and cytokine/TCR gene deletion models in the study of inflammatory bowel disease

Abstract

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