Abstract
Background: Asthma is a common chronic disease among young adults, and several studies have reported increased
mortality rates in patients with asthma. However, no study has described sudden unexpected death in a nationwide
setting in patients with uncontrolled asthma. We defined uncontrolled asthma as a previous hospital admittance
because of asthma (of any severity) or when asthma was considered to have influenced the death according to
the death certificate. The purpose of this study is to increase the medical focus on young persons with uncontrolled
asthma and thereby hopefully aid in preventing sudden unexpected deaths. We therefore aimed to describe clinical
characteristics, symptoms, causes of death, and contact with the healthcare system prior to sudden unexpected death
in young persons with uncontrolled asthma.
Methods: Through the review of death certificates, we found 625 sudden unexpected death cases in individuals
aged 1–35 years in Denmark from 2000 to 2006. Of those, 49 persons with uncontrolled asthma were identified.
Previous contacts with the healthcare system were identified, and available records from general practitioners
were retrieved.
Results: We identified 49 individuals who suffered from uncontrolled asthma. This corresponds to an incidence
rate of 0.32 per 100,000 person-years. The cause of death in 31 cases (63%) was sudden cardiac death, and in 13
cases (27%), it was a fatal asthma attack.
Symptoms (chest pain, dyspnea, seizures, general malaise, syncope, and palpitations) prior to death were reported
in 41 (84%) of the cases. In 34 (69%) of the cases, antecedent symptoms (symptoms >24 hours before death) were
present, and 28 (57%) patients had prodromal symptoms (symptoms <24 hours before death). The most common
antecedent symptoms were dyspnea and chest pain, whereas the most common prodromal symptoms were dyspnea,
general malaise, and/or fatigue. Twenty-eight patients (57%) sought medical advice from a general practitioner and/or
emergency department due to these symptoms.
Conclusion: The cause of death was predominantly sudden cardiac death followed by fatal asthma attack. We found
that 41 (84%) of patients suffered from symptoms prior to death and that 28 (57%) sought medical advice from the
emergency department and/or general practitioners
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 35 |
| Tidsskrift | B M C Pulmonary Medicine |
| Vol/bind | 15 |
| Udgave nummer | 35 |
| Sider (fra-til) | 1-8 |
| Antal sider | 8 |
| ISSN | 1471-2466 |
| DOI | |
| Status | Udgivet - 14 apr. 2015 |