@article{857c9e70ebce11ddbf70000ea68e967b,
title = "Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells",
abstract = "A detailed analysis of the residues within an immunogenic peptide that endow it with the capacity to interact with Ia and to be recognized by T cells is presented. Ia interacts with only a few of the peptide residues and overall exhibits a very broad specificity. Some residues appear to interact both with Ia and with T cells, leading to a model in which a peptide antigen is 'sandwiched' between Ia and the T-cell receptor.",
author = "A Sette and S Buus and S Colon and Smith, {J A} and C Miles and Grey, {H M}",
note = "Keywords: Amino Acid Sequence; Animals; Antigens; Binding, Competitive; Histocompatibility Antigens Class II; Hybridomas; Ovalbumin; Peptide Fragments; Peptides; Structure-Activity Relationship; T-Lymphocytes",
year = "1987",
doi = "10.1038/328395a0",
language = "English",
volume = "328",
pages = "395--9",
journal = "Nature",
issn = "0028-0836",
publisher = "nature publishing group",
number = "6129",
}