Sleep spindle alterations in patients with Parkinson's disease

Julie Anja Engelhard Christensen; Miki Nikolic; Simon C Warby; Henriette Koch; Marielle Zoetmulder; Rune Frandsen; Keivan K Moghadam; Helge B D Sorensen; Emmanuel Mignot; Poul J Jennum

doi:10.3389/fnhum.2015.00233

Sleep spindle alterations in patients with Parkinson's disease

Julie Anja Engelhard Christensen, Miki Nikolic, Simon C Warby, Henriette Koch, Marielle Zoetmulder, Rune Frandsen, Keivan K Moghadam, Helge B D Sorensen, Emmanuel Mignot, Poul J Jennum

Center for Sund Aldring

21 Citationer (Scopus)

Abstract

The aim of this study was to identify changes of sleep spindles (SS) in the EEG of patients with Parkinson's disease (PD). Five sleep experts manually identified SS at a central scalp location (C3-A2) in 15 PD and 15 age- and sex-matched control subjects. Each SS was given a confidence score, and by using a group consensus rule, 901 SS were identified and characterized by their (1) duration, (2) oscillation frequency, (3) maximum peak-to-peak amplitude, (4) percent-to-peak amplitude, and (5) density. Between-group comparisons were made for all SS characteristics computed, and significant changes for PD patients vs. control subjects were found for duration, oscillation frequency, maximum peak-to-peak amplitude and density. Specifically, SS density was lower, duration was longer, oscillation frequency slower and maximum peak-to-peak amplitude higher in patients vs. controls. We also computed inter-expert reliability in SS scoring and found a significantly lower reliability in scoring definite SS in patients when compared to controls. How neurodegeneration in PD could influence SS characteristics is discussed. We also note that the SS morphological changes observed here may affect automatic detection of SS in patients with PD or other neurodegenerative disorders (NDDs).

Originalsprog	Engelsk
Artikelnummer	00233
Tidsskrift	Frontiers in Human Neuroscience
Vol/bind	9
Antal sider	13
ISSN	1662-5161
DOI	https://doi.org/10.3389/fnhum.2015.00233
Status	Udgivet - 1 maj 2015

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10.3389/fnhum.2015.00233

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title = "Sleep spindle alterations in patients with Parkinson's disease",

abstract = "The aim of this study was to identify changes of sleep spindles (SS) in the EEG of patients with Parkinson's disease (PD). Five sleep experts manually identified SS at a central scalp location (C3-A2) in 15 PD and 15 age- and sex-matched control subjects. Each SS was given a confidence score, and by using a group consensus rule, 901 SS were identified and characterized by their (1) duration, (2) oscillation frequency, (3) maximum peak-to-peak amplitude, (4) percent-to-peak amplitude, and (5) density. Between-group comparisons were made for all SS characteristics computed, and significant changes for PD patients vs. control subjects were found for duration, oscillation frequency, maximum peak-to-peak amplitude and density. Specifically, SS density was lower, duration was longer, oscillation frequency slower and maximum peak-to-peak amplitude higher in patients vs. controls. We also computed inter-expert reliability in SS scoring and found a significantly lower reliability in scoring definite SS in patients when compared to controls. How neurodegeneration in PD could influence SS characteristics is discussed. We also note that the SS morphological changes observed here may affect automatic detection of SS in patients with PD or other neurodegenerative disorders (NDDs).",

author = "Christensen, {Julie Anja Engelhard} and Miki Nikolic and Warby, {Simon C} and Henriette Koch and Marielle Zoetmulder and Rune Frandsen and Moghadam, {Keivan K} and Sorensen, {Helge B D} and Emmanuel Mignot and Jennum, {Poul J}",

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TY - JOUR

T1 - Sleep spindle alterations in patients with Parkinson's disease

AU - Christensen, Julie Anja Engelhard

AU - Nikolic, Miki

AU - Warby, Simon C

AU - Koch, Henriette

AU - Zoetmulder, Marielle

AU - Frandsen, Rune

AU - Moghadam, Keivan K

AU - Sorensen, Helge B D

AU - Mignot, Emmanuel

AU - Jennum, Poul J

PY - 2015/5/1

Y1 - 2015/5/1

N2 - The aim of this study was to identify changes of sleep spindles (SS) in the EEG of patients with Parkinson's disease (PD). Five sleep experts manually identified SS at a central scalp location (C3-A2) in 15 PD and 15 age- and sex-matched control subjects. Each SS was given a confidence score, and by using a group consensus rule, 901 SS were identified and characterized by their (1) duration, (2) oscillation frequency, (3) maximum peak-to-peak amplitude, (4) percent-to-peak amplitude, and (5) density. Between-group comparisons were made for all SS characteristics computed, and significant changes for PD patients vs. control subjects were found for duration, oscillation frequency, maximum peak-to-peak amplitude and density. Specifically, SS density was lower, duration was longer, oscillation frequency slower and maximum peak-to-peak amplitude higher in patients vs. controls. We also computed inter-expert reliability in SS scoring and found a significantly lower reliability in scoring definite SS in patients when compared to controls. How neurodegeneration in PD could influence SS characteristics is discussed. We also note that the SS morphological changes observed here may affect automatic detection of SS in patients with PD or other neurodegenerative disorders (NDDs).

AB - The aim of this study was to identify changes of sleep spindles (SS) in the EEG of patients with Parkinson's disease (PD). Five sleep experts manually identified SS at a central scalp location (C3-A2) in 15 PD and 15 age- and sex-matched control subjects. Each SS was given a confidence score, and by using a group consensus rule, 901 SS were identified and characterized by their (1) duration, (2) oscillation frequency, (3) maximum peak-to-peak amplitude, (4) percent-to-peak amplitude, and (5) density. Between-group comparisons were made for all SS characteristics computed, and significant changes for PD patients vs. control subjects were found for duration, oscillation frequency, maximum peak-to-peak amplitude and density. Specifically, SS density was lower, duration was longer, oscillation frequency slower and maximum peak-to-peak amplitude higher in patients vs. controls. We also computed inter-expert reliability in SS scoring and found a significantly lower reliability in scoring definite SS in patients when compared to controls. How neurodegeneration in PD could influence SS characteristics is discussed. We also note that the SS morphological changes observed here may affect automatic detection of SS in patients with PD or other neurodegenerative disorders (NDDs).

U2 - 10.3389/fnhum.2015.00233

DO - 10.3389/fnhum.2015.00233

M3 - Journal article

C2 - 25983685

SN - 1662-5161

VL - 9

JO - Frontiers in Human Neuroscience

JF - Frontiers in Human Neuroscience

M1 - 00233

ER -

Sleep spindle alterations in patients with Parkinson's disease

Abstract

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