@article{675acd40537411df928f000ea68e967b,
title = "Serum levels of ficolin-3 (Hakata antigen) in patients with systemic lupus erythematosus",
abstract = "OBJECTIVE: Ficolin-3 is a serum protein of putative importance in autoimmunity. Our objective was to investigate any differential expression of ficolin-3 in patients with systemic lupus erythematosus (SLE) or its clinical subsets. METHODS: Serum levels of ficolin-3 (S-ficolin-3) were determined in 95 patients with SLE and 103 healthy controls using an ELISA. RESULTS: Median S-ficolin-3 was 56.1 microg/ml (range 0 to >or=87.3) and 32.4 microg/ml (10 to >or=87.3) in patients and controls, respectively (p<0.001). Increased S-ficolin-3 was associated with hemolysis, positive Coombs test, and lymphopenia, but not with SLE Disease Activity Index scores or C-reactive protein. In one patient without detectable S-ficolin-3, the FCN3 gene appeared normal. CONCLUSION: The elevation of S-ficolin-3 and its association with specific manifestations in SLE may indicate a pathogenetic role of ficolin-3 in SLE.",
author = "T. Andersen and L. Munthe-Fog and P. Garred and S{\o}ren Jacobsen and Trine Andersen and Lea Munthe-Fog and Peter Garred and S{\o}ren Jacobsen",
note = "Keywords: Adolescent; Adult; Aged; Child; Female; Glycoproteins; Humans; Lectins; Lupus Erythematosus, Systemic; Male; Middle Aged; Severity of Illness Index; Young Adult",
year = "2009",
month = apr,
day = "1",
doi = "10.3899/jrheum.080361",
language = "English",
volume = "36",
pages = "757--9",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology Publishing Co. Ltd.",
number = "4",
}