Role of marginal vitamin C deficiency in atherogenesis: In vivo models and clinical studies

Henriette Rønne Frikke-Schmidt; Jens Lykkesfeldt

doi:10.1111/j.1742-7843.2009.00420.x

Role of marginal vitamin C deficiency in atherogenesis: In vivo models and clinical studies

Henriette Rønne Frikke-Schmidt, Jens Lykkesfeldt

46 Citationer (Scopus)

Abstract

Vitamin C is a pivotal redox modulater in many biological reactions of which several remain poorly understood. Naturally, vitamin C has been subject of many investigations over the past decades in relation to its possible beneficial effects on cardiovascular disease primarily based on its powerful yet general antioxidant properties. However, growing epidemiological, clinical and experimental evidence now suggests a more specific role of ascorbate in vasomotion and in the prevention of atherosclerosis. For example, in contrast to most other biological antioxidants, administration of vitamin C can apparently induce vasodilation. Millions of people worldwide can be diagnosed with vitamin C deficiency according to accepted definitions. In this perspective, the present review examines the evidence for a specific link between vitamin C deficiency and increased risk of atherosclerosis as well as the possible mechanisms by which vitamin C may exert its protective function.

Originalsprog	Engelsk
Tidsskrift	Basic & Clinical Pharmacology & Toxicology
Vol/bind	104
Udgave nummer	6
Sider (fra-til)	419-433
Antal sider	15
ISSN	1742-7835
DOI	https://doi.org/10.1111/j.1742-7843.2009.00420.x
Status	Udgivet - 2009

Adgang til dokumentet

10.1111/j.1742-7843.2009.00420.x

Citationsformater

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title = "Role of marginal vitamin C deficiency in atherogenesis: In vivo models and clinical studies",

abstract = "Vitamin C is a pivotal redox modulater in many biological reactions of which several remain poorly understood. Naturally, vitamin C has been subject of many investigations over the past decades in relation to its possible beneficial effects on cardiovascular disease primarily based on its powerful yet general antioxidant properties. However, growing epidemiological, clinical and experimental evidence now suggests a more specific role of ascorbate in vasomotion and in the prevention of atherosclerosis. For example, in contrast to most other biological antioxidants, administration of vitamin C can apparently induce vasodilation. Millions of people worldwide can be diagnosed with vitamin C deficiency according to accepted definitions. In this perspective, the present review examines the evidence for a specific link between vitamin C deficiency and increased risk of atherosclerosis as well as the possible mechanisms by which vitamin C may exert its protective function.",

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T1 - Role of marginal vitamin C deficiency in atherogenesis

T2 - In vivo models and clinical studies

AU - Frikke-Schmidt, Henriette Rønne

AU - Lykkesfeldt, Jens

PY - 2009

Y1 - 2009

N2 - Vitamin C is a pivotal redox modulater in many biological reactions of which several remain poorly understood. Naturally, vitamin C has been subject of many investigations over the past decades in relation to its possible beneficial effects on cardiovascular disease primarily based on its powerful yet general antioxidant properties. However, growing epidemiological, clinical and experimental evidence now suggests a more specific role of ascorbate in vasomotion and in the prevention of atherosclerosis. For example, in contrast to most other biological antioxidants, administration of vitamin C can apparently induce vasodilation. Millions of people worldwide can be diagnosed with vitamin C deficiency according to accepted definitions. In this perspective, the present review examines the evidence for a specific link between vitamin C deficiency and increased risk of atherosclerosis as well as the possible mechanisms by which vitamin C may exert its protective function.

AB - Vitamin C is a pivotal redox modulater in many biological reactions of which several remain poorly understood. Naturally, vitamin C has been subject of many investigations over the past decades in relation to its possible beneficial effects on cardiovascular disease primarily based on its powerful yet general antioxidant properties. However, growing epidemiological, clinical and experimental evidence now suggests a more specific role of ascorbate in vasomotion and in the prevention of atherosclerosis. For example, in contrast to most other biological antioxidants, administration of vitamin C can apparently induce vasodilation. Millions of people worldwide can be diagnosed with vitamin C deficiency according to accepted definitions. In this perspective, the present review examines the evidence for a specific link between vitamin C deficiency and increased risk of atherosclerosis as well as the possible mechanisms by which vitamin C may exert its protective function.

U2 - 10.1111/j.1742-7843.2009.00420.x

DO - 10.1111/j.1742-7843.2009.00420.x

M3 - Journal article

C2 - 19489786

SN - 1742-7835

VL - 104

SP - 419

EP - 433

JO - Basic and Clinical Pharmacology and Toxicology

JF - Basic and Clinical Pharmacology and Toxicology

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