Risk factors for community-acquired bacterial meningitis

TY - JOUR

T1 - Risk factors for community-acquired bacterial meningitis

AU - Lundbo, Lene Fogt

AU - Benfield, Thomas

PY - 2017/6/3

Y1 - 2017/6/3

N2 - BACKGROUND: Bacterial meningitis is a significant burden of disease and mortality in all age groups worldwide despite the development of effective conjugated vaccines. The pathogenesis of bacterial meningitis is based on complex and incompletely understood host-pathogen interactions. Some of these are pathogen-specific, while some are shared between different bacteria.METHODS: We searched the database PubMed to identify host risk factors for bacterial meningitis caused by the pathogens Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae type b, because they are three most common causative bacteria beyond the neonatal period.RESULTS: We describe a number of risk factors; including socioeconomic factors, age, genetic variation of the host and underlying medical conditions associated with increased susceptibility to invasive bacterial infections in both children and adults.CONCLUSIONS: As conjugated vaccines are available for these infections, it is of utmost importance to identify high risk patients to be able to prevent invasive disease.

AB - BACKGROUND: Bacterial meningitis is a significant burden of disease and mortality in all age groups worldwide despite the development of effective conjugated vaccines. The pathogenesis of bacterial meningitis is based on complex and incompletely understood host-pathogen interactions. Some of these are pathogen-specific, while some are shared between different bacteria.METHODS: We searched the database PubMed to identify host risk factors for bacterial meningitis caused by the pathogens Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae type b, because they are three most common causative bacteria beyond the neonatal period.RESULTS: We describe a number of risk factors; including socioeconomic factors, age, genetic variation of the host and underlying medical conditions associated with increased susceptibility to invasive bacterial infections in both children and adults.CONCLUSIONS: As conjugated vaccines are available for these infections, it is of utmost importance to identify high risk patients to be able to prevent invasive disease.

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Bacterial Vaccines/administration & dosage

KW - Child

KW - Child, Preschool

KW - Community-Acquired Infections/etiology

KW - Female

KW - Haemophilus influenzae type b/isolation & purification

KW - Host-Pathogen Interactions

KW - Humans

KW - Infant

KW - Male

KW - Meningitis, Bacterial/etiology

KW - Meningitis, Haemophilus/microbiology

KW - Meningitis, Meningococcal/microbiology

KW - Meningitis, Pneumococcal/microbiology

KW - Neisseria meningitidis/isolation & purification

KW - Risk Factors

KW - Socioeconomic Factors

KW - Streptococcus pneumoniae/isolation & purification

U2 - 10.1080/23744235.2017.1285046

DO - 10.1080/23744235.2017.1285046

M3 - Review

C2 - 28301990

SN - 2374-4235

VL - 49

SP - 433

EP - 444

JO - Infectious Diseases

JF - Infectious Diseases

IS - 6

ER -