Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT

TY - JOUR

T1 - Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT

AU - Ziebell, Morten

AU - Thomsen, Gerda

AU - Knudsen, Gitte M

AU - de Nijs, Robin

AU - Svarer, Claus

AU - Wagner, Aase

AU - Pinborg, Lars H

PY - 2007/1/1

Y1 - 2007/1/1

N2 - The iodinated cocaine derivative [(123)I]PE2I is a new selective ligand for in vivo studies of the dopamine transporter (DAT) with SPECT. Recently, a bolus/infusion (B/I) protocol for [(123)I]PE2I measurements of DAT density was established [Pinborg LH et al. J Nucl Med 2005;46:1119-271]. The aims of this study were, firstly, to evaluate the test-retest variability using the B/I protocol and, secondly, to evaluate the B/I approach in a new group of healthy subjects using two outcome parameters, BP(1) (C(ROI)/C(plasma)) and BP(2) (C(ROI)/C(REF)).

AB - The iodinated cocaine derivative [(123)I]PE2I is a new selective ligand for in vivo studies of the dopamine transporter (DAT) with SPECT. Recently, a bolus/infusion (B/I) protocol for [(123)I]PE2I measurements of DAT density was established [Pinborg LH et al. J Nucl Med 2005;46:1119-271]. The aims of this study were, firstly, to evaluate the test-retest variability using the B/I protocol and, secondly, to evaluate the B/I approach in a new group of healthy subjects using two outcome parameters, BP(1) (C(ROI)/C(plasma)) and BP(2) (C(ROI)/C(REF)).

U2 - http://dx.doi.org/10.1007/s00259-006-0161-z

DO - http://dx.doi.org/10.1007/s00259-006-0161-z

M3 - Journal article

SN - 1619-7070

VL - 34

SP - 101

EP - 109

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 1

ER -