@article{d6fa668095fa11dd86a6000ea68e967b,
title = "Proteins containing the UBA domain are able to bind to multi-ubiquitin chains.",
abstract = "The UBA domain is a motif found in a variety of proteins, some of which are associated with the ubiquitin-proteasome system. We describe the isolation of a fission-yeast gene, mud1+, which encodes a UBA domain containing protein that is able to bind multi-ubiquitin chains. We show that the UBA domain is responsible for this activity. Two other proteins containing this motif, the fission-yeast homologues of Rad23 and Dsk2, are also shown to bind multi-ubiquitin chains via their UBA domains. These two proteins are implicated, along with the fission-yeast Pus1(S5a/Rpn10) subunit of the 26 S proteasome, in the recognition and turnover of substrates by this proteolytic complex.",
author = "Wilkinson, {C R} and M Seeger and R Hartmann-Petersen and M Stone and M Wallace and C Semple and C Gordon",
note = "Keywords: Amino Acid Motifs; Cell Cycle Proteins; Cysteine Endopeptidases; DNA-Binding Proteins; Fungal Proteins; Genes, Fungal; Genes, Reporter; Multienzyme Complexes; Phenotype; Proteasome Endopeptidase Complex; Protein Binding; Recombinant Fusion Proteins; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Surface Plasmon Resonance; Ubiquitin; Ubiquitins",
year = "2001",
doi = "10.1038/ncb1001-939",
language = "English",
volume = "3",
pages = "939--43",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "nature publishing group",
number = "10",
}