Prolonged naproxen joint residence time after intra-articular injection of lipophilic solutions comprising a naproxen glycolamide ester prodrug in the rat

Medicin og biovidenskab

• Anti-Inflammatory Agents 4%
• Body Weight 3%
• Castor Oil 8%
• Esters 45%
• glycolamide 100%
• Intra-Articular Injections 56%
• Joints 31%
• Knee Joint 5%
• Naproxen 57%
• Oils 44%
• Pharmaceutical Preparations 2%
• Prodrugs 49%
• Serum 10%
• Synovial Fluid 6%
• Triglycerides 4%
• Viscosity 12%

Kemiske forbindelser

• Aqueous Solution 3%
• Castor Oil 9%
• Ester 27%
• Intraarticular 76%
• Naproxen 55%
• Nonsteroid Antiinflammatory Agent 8%
• Percent Reduction 8%
• Prodrug 47%
• Residence Time 46%
• Time 5%
• Triglyceride 7%
• Weight 3%