Pretreatment quality of life in patients with rectal cancer is associated with intrusive thoughts and sense of coherence

Dan Asplund; Thue Bisgaard; David Bock; Jakob Burcharth; Elisabeth González; Eva Haglind; Yanislav Kolev; Peter Matthiessen; Carina Rosander; Jacob Rosenberg; Kenneth Smedh; Marina Åkerblom Sörensson; Eva Angenete

doi:10.1007/s00384-017-2900-y

Pretreatment quality of life in patients with rectal cancer is associated with intrusive thoughts and sense of coherence

Dan Asplund^*, Thue Bisgaard, David Bock, Jakob Burcharth, Elisabeth González, Eva Haglind, Yanislav Kolev, Peter Matthiessen, Carina Rosander, Jacob Rosenberg, Kenneth Smedh, Marina Åkerblom Sörensson, Eva Angenete

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

5 Citationer (Scopus)

46 Downloads (Pure)

Abstract

Purpose: Quality of life may predict survival. In addition to clinical variables, it may be influenced by psychological factors, some of which may be accessible for intervention. The primary objective of this study was to investigate the association of intrusive thoughts and the patients’ sense of coherence with pretreatment quality of life in patients with newly diagnosed rectal cancer. Methods: Patients were prospectively included in 16 hospitals in Sweden and Denmark. They answered an extensive questionnaire after receiving their treatment plan. Clinical data were retrieved from national quality registries for rectal cancer. Results: Of 1248 included patients, a total of 1085 were evaluable. Pretreatment global health-related and overall quality of life was lower in patients planned for palliative compared with curative treatment (median 53 vs. 80 on the EuroQoL visual analogue scale, p < 0.001 and odds ratio 0.56, 95% confidence interval 0.36–0.88, respectively). Quality of life was associated with intrusive thoughts (odds ratio 0.33, 95% confidence interval 0.24–0.45) and sense of coherence (odds ratio 0.44, 95% confidence interval 0.37–0.52) irrespective of the treatment plan. Conclusions: Pretreatment quality of life was influenced by the intent of treatment as well as by intrusive thoughts and the patients’ sense of coherence. Interventions could modify these psychological factors, and future studies should focus on initiatives to improve quality of life for this group of patients.

Originalsprog	Engelsk
Tidsskrift	International Journal of Colorectal Disease
Vol/bind	32
Udgave nummer	11
Sider (fra-til)	1639-1647
Antal sider	9
ISSN	0179-1958
DOI	https://doi.org/10.1007/s00384-017-2900-y
Status	Udgivet - nov. 2017

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Asplund, D., Bisgaard, T., Bock, D., Burcharth, J., González, E., Haglind, E., Kolev, Y., Matthiessen, P., Rosander, C., Rosenberg, J., Smedh, K., Sörensson, M. Å., & Angenete, E. (2017). Pretreatment quality of life in patients with rectal cancer is associated with intrusive thoughts and sense of coherence. International Journal of Colorectal Disease, 32(11), 1639-1647. https://doi.org/10.1007/s00384-017-2900-y

Asplund, D, Bisgaard, T, Bock, D, Burcharth, J, González, E, Haglind, E, Kolev, Y, Matthiessen, P, Rosander, C, Rosenberg, J, Smedh, K, Sörensson, MÅ & Angenete, E 2017, 'Pretreatment quality of life in patients with rectal cancer is associated with intrusive thoughts and sense of coherence', International Journal of Colorectal Disease, bind 32, nr. 11, s. 1639-1647. https://doi.org/10.1007/s00384-017-2900-y

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title = "Pretreatment quality of life in patients with rectal cancer is associated with intrusive thoughts and sense of coherence",

abstract = "Purpose: Quality of life may predict survival. In addition to clinical variables, it may be influenced by psychological factors, some of which may be accessible for intervention. The primary objective of this study was to investigate the association of intrusive thoughts and the patients{\textquoteright} sense of coherence with pretreatment quality of life in patients with newly diagnosed rectal cancer. Methods: Patients were prospectively included in 16 hospitals in Sweden and Denmark. They answered an extensive questionnaire after receiving their treatment plan. Clinical data were retrieved from national quality registries for rectal cancer. Results: Of 1248 included patients, a total of 1085 were evaluable. Pretreatment global health-related and overall quality of life was lower in patients planned for palliative compared with curative treatment (median 53 vs. 80 on the EuroQoL visual analogue scale, p < 0.001 and odds ratio 0.56, 95% confidence interval 0.36–0.88, respectively). Quality of life was associated with intrusive thoughts (odds ratio 0.33, 95% confidence interval 0.24–0.45) and sense of coherence (odds ratio 0.44, 95% confidence interval 0.37–0.52) irrespective of the treatment plan. Conclusions: Pretreatment quality of life was influenced by the intent of treatment as well as by intrusive thoughts and the patients{\textquoteright} sense of coherence. Interventions could modify these psychological factors, and future studies should focus on initiatives to improve quality of life for this group of patients.",

keywords = "Cancer, Clinical trial, Intrusive thoughts, Oncology, Quality of life, Rectal cancer, Sense of coherence",

author = "Dan Asplund and Thue Bisgaard and David Bock and Jakob Burcharth and Elisabeth Gonz{\'a}lez and Eva Haglind and Yanislav Kolev and Peter Matthiessen and Carina Rosander and Jacob Rosenberg and Kenneth Smedh and S{\"o}rensson, {Marina {\AA}kerblom} and Eva Angenete",

year = "2017",

month = nov,

doi = "10.1007/s00384-017-2900-y",

language = "English",

volume = "32",

pages = "1639--1647",

journal = "International Journal of Colorectal Disease",

issn = "0179-1958",

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number = "11",

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TY - JOUR

T1 - Pretreatment quality of life in patients with rectal cancer is associated with intrusive thoughts and sense of coherence

AU - Asplund, Dan

AU - Bisgaard, Thue

AU - Bock, David

AU - Burcharth, Jakob

AU - González, Elisabeth

AU - Haglind, Eva

AU - Kolev, Yanislav

AU - Matthiessen, Peter

AU - Rosander, Carina

AU - Rosenberg, Jacob

AU - Smedh, Kenneth

AU - Sörensson, Marina Åkerblom

AU - Angenete, Eva

PY - 2017/11

Y1 - 2017/11

N2 - Purpose: Quality of life may predict survival. In addition to clinical variables, it may be influenced by psychological factors, some of which may be accessible for intervention. The primary objective of this study was to investigate the association of intrusive thoughts and the patients’ sense of coherence with pretreatment quality of life in patients with newly diagnosed rectal cancer. Methods: Patients were prospectively included in 16 hospitals in Sweden and Denmark. They answered an extensive questionnaire after receiving their treatment plan. Clinical data were retrieved from national quality registries for rectal cancer. Results: Of 1248 included patients, a total of 1085 were evaluable. Pretreatment global health-related and overall quality of life was lower in patients planned for palliative compared with curative treatment (median 53 vs. 80 on the EuroQoL visual analogue scale, p < 0.001 and odds ratio 0.56, 95% confidence interval 0.36–0.88, respectively). Quality of life was associated with intrusive thoughts (odds ratio 0.33, 95% confidence interval 0.24–0.45) and sense of coherence (odds ratio 0.44, 95% confidence interval 0.37–0.52) irrespective of the treatment plan. Conclusions: Pretreatment quality of life was influenced by the intent of treatment as well as by intrusive thoughts and the patients’ sense of coherence. Interventions could modify these psychological factors, and future studies should focus on initiatives to improve quality of life for this group of patients.

AB - Purpose: Quality of life may predict survival. In addition to clinical variables, it may be influenced by psychological factors, some of which may be accessible for intervention. The primary objective of this study was to investigate the association of intrusive thoughts and the patients’ sense of coherence with pretreatment quality of life in patients with newly diagnosed rectal cancer. Methods: Patients were prospectively included in 16 hospitals in Sweden and Denmark. They answered an extensive questionnaire after receiving their treatment plan. Clinical data were retrieved from national quality registries for rectal cancer. Results: Of 1248 included patients, a total of 1085 were evaluable. Pretreatment global health-related and overall quality of life was lower in patients planned for palliative compared with curative treatment (median 53 vs. 80 on the EuroQoL visual analogue scale, p < 0.001 and odds ratio 0.56, 95% confidence interval 0.36–0.88, respectively). Quality of life was associated with intrusive thoughts (odds ratio 0.33, 95% confidence interval 0.24–0.45) and sense of coherence (odds ratio 0.44, 95% confidence interval 0.37–0.52) irrespective of the treatment plan. Conclusions: Pretreatment quality of life was influenced by the intent of treatment as well as by intrusive thoughts and the patients’ sense of coherence. Interventions could modify these psychological factors, and future studies should focus on initiatives to improve quality of life for this group of patients.

KW - Cancer

KW - Clinical trial

KW - Intrusive thoughts

KW - Oncology

KW - Quality of life

KW - Rectal cancer

KW - Sense of coherence

UR - https://link.springer.com/article/10.1007%2Fs00384-017-2953-y

U2 - 10.1007/s00384-017-2900-y

DO - 10.1007/s00384-017-2900-y

M3 - Journal article

C2 - 28913686

AN - SCOPUS:85029509206

SN - 0179-1958

VL - 32

SP - 1639

EP - 1647

JO - International Journal of Colorectal Disease

JF - International Journal of Colorectal Disease

IS - 11

ER -

Pretreatment quality of life in patients with rectal cancer is associated with intrusive thoughts and sense of coherence

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