Prenatal prochloraz treatment significantly increases pregnancy length and reduces offspring weight but does not affect social-olfactory memory in rats

Oksana Dmytriyeva; Boris Klementiev; Vladimir Berezin; Elisabeth Bock

doi:10.1016/j.etp.2012.06.001

Prenatal prochloraz treatment significantly increases pregnancy length and reduces offspring weight but does not affect social-olfactory memory in rats

Oksana Dmytriyeva, Boris Klementiev, Vladimir Berezin, Elisabeth Bock

5 Citationer (Scopus)

Abstract

Metabolites of the commonly used imidazole fungicide prochloraz are androgen receptor antagonists. They have been shown to block androgen-driven development and compromise reproductive function. We tested the effect of prochloraz on cognitive behavior following exposure to this fungicide during the perinatal period. Pregnant Wistar rats were administered a 200mg/kg dose of prochloraz on gestational day (GD) 7, GD11, and GD15. The social recognition test (SRT) was performed on 7-week-old male rat offspring. We found an increase in pregnancy length and a significantly reduced pup weight on PND15 and PND40 but no effect of prenatal prochloraz exposure on social investigation or acquisition of social-olfactory memory.

Originalsprog	Engelsk
Tidsskrift	Experimental and Toxicologic Pathology
Vol/bind	65
Udgave nummer	5
Sider (fra-til)	591–593
Antal sider	5
ISSN	0940-2993
DOI	https://doi.org/10.1016/j.etp.2012.06.001
Status	Udgivet - jul. 2013

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10.1016/j.etp.2012.06.001

Citationsformater

Prenatal prochloraz treatment significantly increases pregnancy length and reduces offspring weight but does not affect social-olfactory memory in rats. / Dmytriyeva, Oksana; Klementiev, Boris; Berezin, Vladimir et al.

I: Experimental and Toxicologic Pathology, Bind 65, Nr. 5, 07.2013, s. 591–593.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "Metabolites of the commonly used imidazole fungicide prochloraz are androgen receptor antagonists. They have been shown to block androgen-driven development and compromise reproductive function. We tested the effect of prochloraz on cognitive behavior following exposure to this fungicide during the perinatal period. Pregnant Wistar rats were administered a 200mg/kg dose of prochloraz on gestational day (GD) 7, GD11, and GD15. The social recognition test (SRT) was performed on 7-week-old male rat offspring. We found an increase in pregnancy length and a significantly reduced pup weight on PND15 and PND40 but no effect of prenatal prochloraz exposure on social investigation or acquisition of social-olfactory memory.",

author = "Oksana Dmytriyeva and Boris Klementiev and Vladimir Berezin and Elisabeth Bock",

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AU - Dmytriyeva, Oksana

AU - Klementiev, Boris

AU - Berezin, Vladimir

AU - Bock, Elisabeth

PY - 2013/7

Y1 - 2013/7

N2 - Metabolites of the commonly used imidazole fungicide prochloraz are androgen receptor antagonists. They have been shown to block androgen-driven development and compromise reproductive function. We tested the effect of prochloraz on cognitive behavior following exposure to this fungicide during the perinatal period. Pregnant Wistar rats were administered a 200mg/kg dose of prochloraz on gestational day (GD) 7, GD11, and GD15. The social recognition test (SRT) was performed on 7-week-old male rat offspring. We found an increase in pregnancy length and a significantly reduced pup weight on PND15 and PND40 but no effect of prenatal prochloraz exposure on social investigation or acquisition of social-olfactory memory.

AB - Metabolites of the commonly used imidazole fungicide prochloraz are androgen receptor antagonists. They have been shown to block androgen-driven development and compromise reproductive function. We tested the effect of prochloraz on cognitive behavior following exposure to this fungicide during the perinatal period. Pregnant Wistar rats were administered a 200mg/kg dose of prochloraz on gestational day (GD) 7, GD11, and GD15. The social recognition test (SRT) was performed on 7-week-old male rat offspring. We found an increase in pregnancy length and a significantly reduced pup weight on PND15 and PND40 but no effect of prenatal prochloraz exposure on social investigation or acquisition of social-olfactory memory.

U2 - 10.1016/j.etp.2012.06.001

DO - 10.1016/j.etp.2012.06.001

M3 - Journal article

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JO - Experimental and Toxicologic Pathology

JF - Experimental and Toxicologic Pathology

IS - 5

ER -

Prenatal prochloraz treatment significantly increases pregnancy length and reduces offspring weight but does not affect social-olfactory memory in rats

Abstract

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